Immuno-polymeric Drugs For Prostate Cancer Therapy
Funder
National Health and Medical Research Council
Funding Amount
$626,995.00
Summary
Prostate cancer is the most common cancer in men over 50 and the second most frequent cause of cancer deaths in Western society. Docetaxel is the first line of chemotherapy when other intervention strategies are unsuccessful, but 30% of patients suffer from severe side-effects. To address this problem, we will utilise carriers for docetaxel that directly target prostate tumours using a novel antibody approach. This increases accumulation at the tumour site while decreasing off-target toxicity.
Exploring Scanning Ultrasound (SUS), A Novel Method To Treat And Prevent Neurodegenerative Disease
Funder
National Health and Medical Research Council
Funding Amount
$765,708.00
Summary
We developed a novel scanning ultrasound (SUS) protocol that clears toxic protein aggregates and restores memory function in mouse models of Alzheimer's disease (AD), without the need for therapeutic agents. Here we aim to determine whether SUS has preventative potential, whether there are synergistic effects, and whether a therapeutic antibody combined with SUS leads to an enhanced therapeutic outcome. Together this will guide the development of an ultrasound therapy in AD patients.
Poly(amino acids) as immune stimulators. This project aims to develop nanoparticles built from natural hydrophobic amino acids as an immune stimulatory delivery system for peptide antigens. Currently available immune stimulants (adjuvants) are often toxic and/or are poorly chemically defined fragments of bacteria or toxins and vary from batch-to-batch. New adjuvants are in high demand; especially to facilitate the use of optimal, but weakly immunogenic, peptide antigens. It is expected that the ....Poly(amino acids) as immune stimulators. This project aims to develop nanoparticles built from natural hydrophobic amino acids as an immune stimulatory delivery system for peptide antigens. Currently available immune stimulants (adjuvants) are often toxic and/or are poorly chemically defined fragments of bacteria or toxins and vary from batch-to-batch. New adjuvants are in high demand; especially to facilitate the use of optimal, but weakly immunogenic, peptide antigens. It is expected that the proposed project will develop a novel efficient, safe and notably biodegradable self-adjuvanting delivery system that can be fully customised to match an antigen of choice. This foundational research should provide important advances for commercial immune stimulatory applications.Read moreRead less
Progressive collapse resistance of concrete flat plate structures. This project aims to systematically and thoroughly investigate the progressive collapse mechanisms and resistance capacity of concrete flat plate structures. They represent one of the most common construction systems used worldwide in modern days, yet their progressive collapse mechanisms require attention and limited collapse prevention design guidelines are available. The outcomes are expected to broaden and deepen the existing ....Progressive collapse resistance of concrete flat plate structures. This project aims to systematically and thoroughly investigate the progressive collapse mechanisms and resistance capacity of concrete flat plate structures. They represent one of the most common construction systems used worldwide in modern days, yet their progressive collapse mechanisms require attention and limited collapse prevention design guidelines are available. The outcomes are expected to broaden and deepen the existing theoretical framework and knowledge base, prevent injury and loss of life in both new and existing buildings. This is expected ultimately to contribute to the establishment of a set of collapse-resistant design guidelines for further development of relevant Australian and international standards.Read moreRead less
Erosion processes in soils across scales. This project aims to develop a monitoring tool for predicting the evolution of internal erosion in dams based on innovative electromagnetic observation methods. Internal erosion is an insidious process occurring in the obscurity of the soil’s pore system until its consequences become visible and threaten the stability of the dams. These water retaining structures are vital for the future water and energy supply for our society and their failure can be ca ....Erosion processes in soils across scales. This project aims to develop a monitoring tool for predicting the evolution of internal erosion in dams based on innovative electromagnetic observation methods. Internal erosion is an insidious process occurring in the obscurity of the soil’s pore system until its consequences become visible and threaten the stability of the dams. These water retaining structures are vital for the future water and energy supply for our society and their failure can be catastrophic. By establishing an improved understanding of internal erosion as a sequence of processes on various scales, from the onset of erosion until the failure of the structure, this project will place Australia at the forefront of dam safety assessment.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100722
Funder
Australian Research Council
Funding Amount
$362,245.00
Summary
Enabling Novel Hydrogen Storage via Combustible Ice for a Low-Carbon Future. This project aims to develop a new method for sustainable hydrogen storage. Hydrogen is vital for decarbonising Australia's economy, yet finding an efficient way for hydrogen storage is a global challenge. This project seeks to encapsulate hydrogen effectively in water to produce hydrogen-carrying combustible ice for efficient large-scale hydrogen storage, taking the advantages of water as the safest and cheapest raw ma ....Enabling Novel Hydrogen Storage via Combustible Ice for a Low-Carbon Future. This project aims to develop a new method for sustainable hydrogen storage. Hydrogen is vital for decarbonising Australia's economy, yet finding an efficient way for hydrogen storage is a global challenge. This project seeks to encapsulate hydrogen effectively in water to produce hydrogen-carrying combustible ice for efficient large-scale hydrogen storage, taking the advantages of water as the safest and cheapest raw material. Expected outcomes are cutting-edge knowledge and a new pathway of hydrogen storage. This project would contribute to turning Australia’s abundant renewable energy resources into substantial economic and environmental benefits and promote Australia's competitive edge in the global transition toward a low-carbon future.Read moreRead less
Failure Mechanisms of Roof Cladding under Fluctuating Wind Loads. Wind damage to low-rise buildings cause disruption to communities and result in economic losses. Improvements to the most vulnerable part (i.e. roof) will therefore have national benefits and associated economic benefits. Currently, roofing systems used in cyclonic areas are evaluated to DABM in the Northern Territory and to TR440 elsewhere, requiring the same product be tested under two different (and unsatisfactory) specificat ....Failure Mechanisms of Roof Cladding under Fluctuating Wind Loads. Wind damage to low-rise buildings cause disruption to communities and result in economic losses. Improvements to the most vulnerable part (i.e. roof) will therefore have national benefits and associated economic benefits. Currently, roofing systems used in cyclonic areas are evaluated to DABM in the Northern Territory and to TR440 elsewhere, requiring the same product be tested under two different (and unsatisfactory) specifications. This is due to the limited understanding of wind-induced fatigue of cladding. This project will provide the framework for understanding and minimizing cladding fatigue. A realistic single test will also reduce cost and result in better design systems.Read moreRead less
Reducing Blackout Risk through Live Modelling and Monitoring. This project aims to reduce the risk of blackouts through the development of on-line systems for modelling and monitoring of loads and power system controllers. This project is a collaboration with Transgrid, Powerlink, Vencorp and ElectraNetSA, four Transmission companies renowned for innovation in the area of system stability. The project proposes to develop innovative algorithms and to implement these algorithms using advanced hard ....Reducing Blackout Risk through Live Modelling and Monitoring. This project aims to reduce the risk of blackouts through the development of on-line systems for modelling and monitoring of loads and power system controllers. This project is a collaboration with Transgrid, Powerlink, Vencorp and ElectraNetSA, four Transmission companies renowned for innovation in the area of system stability. The project proposes to develop innovative algorithms and to implement these algorithms using advanced hardware, software and communication systems to dynamically generate decision tools for safe and efficient power system operating conditions. These systems will also generate alarms if any risky operational situations arise.Read moreRead less
Contaminant Transport in Marine Sediment. Sediments in bays and estuaries are often contaminated. The inorganic contaminants in sediments can be released back into the water body through mass transfer processes. The mass transfer rate is largely controlled by the wave-driven seepage flux across the seabed. Quantification of this flux is thus a key factor in modelling water quality of coastal water bodies. This project aims to: (1) develop models forwave-induced seepage flux within sediments and ....Contaminant Transport in Marine Sediment. Sediments in bays and estuaries are often contaminated. The inorganic contaminants in sediments can be released back into the water body through mass transfer processes. The mass transfer rate is largely controlled by the wave-driven seepage flux across the seabed. Quantification of this flux is thus a key factor in modelling water quality of coastal water bodies. This project aims to: (1) develop models forwave-induced seepage flux within sediments and contaminant transport; and (2) establish the link between seepage flux and contaminant transport. Outcomes of the proposed research will enhance the understanding of the mechanism of contaminant transport in marine sediment.Read moreRead less
Development of Fibre Reinforced Autoclaved Aerated Concrete Products. The construction industry is one of the world's largest consumers of raw materials and it is widely accepted that current material usage trends are unsustainable. Development of new more efficient construction materials is paramount to overcoming this. This novel research will use advanced high strength glass and carbon fibres and polymer resins to improve the structural behaviour, versatility and economic viability of a natio ....Development of Fibre Reinforced Autoclaved Aerated Concrete Products. The construction industry is one of the world's largest consumers of raw materials and it is widely accepted that current material usage trends are unsustainable. Development of new more efficient construction materials is paramount to overcoming this. This novel research will use advanced high strength glass and carbon fibres and polymer resins to improve the structural behaviour, versatility and economic viability of a nationally significant construction material known as Autoclaved Aerated Concrete. The material technologies developed by this research will lead to more efficient material use, a more sustainable materials solution and the potential to export the technology worldwide.Read moreRead less