Nanoengineering materials to combat antimicrobial resistance. This project aims to understand how nanoengineered materials can be designed to kill bacteria and fungi without causing antimicrobial resistance. Resistance to antimicrobial drugs already leads to many thousands of deaths annually and costs society billions of dollars. Nanomaterials have unique abilities to attack microbes in multiple ways that could limit resistance. This project will engineer new antimicrobial nanomaterials tailored ....Nanoengineering materials to combat antimicrobial resistance. This project aims to understand how nanoengineered materials can be designed to kill bacteria and fungi without causing antimicrobial resistance. Resistance to antimicrobial drugs already leads to many thousands of deaths annually and costs society billions of dollars. Nanomaterials have unique abilities to attack microbes in multiple ways that could limit resistance. This project will engineer new antimicrobial nanomaterials tailored to selectively kill microbes with reduced likelihood of developing resistance by using synergies between inorganic nanoparticles and antimicrobial peptides. This technology could be used to prevent infections and biofilms on surfaces in a wide range of future applications, such as medical / veterinary devicesRead moreRead less
Innovative green technology for bio-particle engineering. Approximately 40% of new pharmaceuticals are poorly soluble in bodily fluids. In many cases this leads to poor bioavailability, and consequent undesirable side effects as a result of high compensating dosages and generally poor patient compliance. These issues will be addressed by developing a green technology for the re-engineering of pharmaceuticals with the objective of increasing bioavilability. The research programme falls within th ....Innovative green technology for bio-particle engineering. Approximately 40% of new pharmaceuticals are poorly soluble in bodily fluids. In many cases this leads to poor bioavailability, and consequent undesirable side effects as a result of high compensating dosages and generally poor patient compliance. These issues will be addressed by developing a green technology for the re-engineering of pharmaceuticals with the objective of increasing bioavilability. The research programme falls within the Designated Research Priority of Frontier Technologies for Building and Transforming Australian Industries. Read moreRead less
Feasibility Studies of Using AC Electrospraying for Biomaterials Synthesis. The proposed interdisciplinary research is anticipated to benefit workers in academia and industry as well as clinicians and patients. Given the demand for point-of-care drug delivery, micro/nano-encapsulation and biomaterials synthesis, the research will be beneficial to the pharmaceutical industry and spin-off/start-up microfluidic businesses interested in commercially developing these devices. It is intended that the ....Feasibility Studies of Using AC Electrospraying for Biomaterials Synthesis. The proposed interdisciplinary research is anticipated to benefit workers in academia and industry as well as clinicians and patients. Given the demand for point-of-care drug delivery, micro/nano-encapsulation and biomaterials synthesis, the research will be beneficial to the pharmaceutical industry and spin-off/start-up microfluidic businesses interested in commercially developing these devices. It is intended that the work will improve quality of life by advancing biomaterials technology and by making medical treatment more readily accessable, portable and more efficient. For patients, the proposed drug delivery device can help prevent sudden initial bursts of dose during administration, which could potentially have fatal consequences.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150101518
Funder
Australian Research Council
Funding Amount
$345,000.00
Summary
Cellular responses to nanoparticles from cells on micropatterned surfaces. The mechanisms underlying cell-nanoparticle interactions remain largely unknown. It has hampered the design and development of innovative nano devices to be used for drug delivery, biomarkers and diagnostics. This project aims to explore the influences of cell size, density, geometry, intercellular communication and substrate properties on cell-nanoparticle interactions. A micropatterning technology is applied to precisel ....Cellular responses to nanoparticles from cells on micropatterned surfaces. The mechanisms underlying cell-nanoparticle interactions remain largely unknown. It has hampered the design and development of innovative nano devices to be used for drug delivery, biomarkers and diagnostics. This project aims to explore the influences of cell size, density, geometry, intercellular communication and substrate properties on cell-nanoparticle interactions. A micropatterning technology is applied to precisely control cell behaviour and provide a novel in vitro cellular model for nanoparticle studies. This project aims to significantly improve the understanding of cell-nanoparticle interactions to provide new insight into nanoparticle design and improve the efficacy of nano devices.Read moreRead less
Using nanostructured biomaterials and stem cells to repair spinal cord injuries. There is currently no effective cure for spinal cord injuries and the consequences to the patient are devastating. Spinal cord injuries affects limb, bowel, bladder and sexual function, and many people with these injuries strugle to maintain their independence. Because people can live for many years after spinal cord damage, the financial and social costs are immense, as many are dependent on the help of others for ....Using nanostructured biomaterials and stem cells to repair spinal cord injuries. There is currently no effective cure for spinal cord injuries and the consequences to the patient are devastating. Spinal cord injuries affects limb, bowel, bladder and sexual function, and many people with these injuries strugle to maintain their independence. Because people can live for many years after spinal cord damage, the financial and social costs are immense, as many are dependent on the help of others for their survival. This proposal tackles this urgent problem by applying advanced nanostructured materials with stem cells, to assist the body in the repair of the spinal cord following injury. Read moreRead less
Nerve regeneration using light responsive hydrogels and stem cells. Diseases of the brain and mind are already the single largest burden of disease in the western world, being greater than cardiac or malignant disease. With Australia's ageing demographic, diseases of the brain and mind will continue to outstrip all other medical causes of loss of productive working life and quality of life. This proposal will confront this serious issue using nanostructured intelligent materials, moving towards ....Nerve regeneration using light responsive hydrogels and stem cells. Diseases of the brain and mind are already the single largest burden of disease in the western world, being greater than cardiac or malignant disease. With Australia's ageing demographic, diseases of the brain and mind will continue to outstrip all other medical causes of loss of productive working life and quality of life. This proposal will confront this serious issue using nanostructured intelligent materials, moving towards the realization of effective stem cell therapies.Read moreRead less
The Scale-up and Evaluation of a Novel Dense Gas Technology Platform for the Production of Particles for Aerosol Drug Delivery. This project provides a unique opportunity to develop an Australian-invented technology in particle engineering, enabling it to enter the international pharmaceutical market. This will enhance the growth of Australia's pharmaceutical research and development, and benefit the Australian pharmaceutical industry. The outcome will also contribute to improvements in the heal ....The Scale-up and Evaluation of a Novel Dense Gas Technology Platform for the Production of Particles for Aerosol Drug Delivery. This project provides a unique opportunity to develop an Australian-invented technology in particle engineering, enabling it to enter the international pharmaceutical market. This will enhance the growth of Australia's pharmaceutical research and development, and benefit the Australian pharmaceutical industry. The outcome will also contribute to improvements in the health and well-being of Australians. The research falls within the Designated National Research Priority of Frontier Technologies for Building and Transforming Australian Industries.Read moreRead less