Attachment of Growth Factors to Pure, Plasma Modified and Coated Titanium Substrates. Titanium and its alloys are routinely used as medical and dental implants. Despite coating with hydroxyapatite, a material well known to improve implant fixation, many such implants fail because of lack of strong integration with bone. This proposal aims at achieving long-term stability of titanium implants through their surface modification and subsequent attachment of growth factors. The use of latter has alr ....Attachment of Growth Factors to Pure, Plasma Modified and Coated Titanium Substrates. Titanium and its alloys are routinely used as medical and dental implants. Despite coating with hydroxyapatite, a material well known to improve implant fixation, many such implants fail because of lack of strong integration with bone. This proposal aims at achieving long-term stability of titanium implants through their surface modification and subsequent attachment of growth factors. The use of latter has already been shown to help bone-implant integration. Successful project implementation will provide titanium implant surfaces that will help achieve speedier and improved implant fixation with long-term stability. Knowledge, expertise and techniques developed will help the industry partner expanding its research base and business and generating wealth in Australia. Training of world-class research students in the emerging field of biotechnology will be another major outcome.Read moreRead less
Covalent Immobilisation of Growth Factors on Plasma Modified Titanium for Achieving Enhanced Bone Growth and Bonding in Implant Prosthetics. This project is aimed at improving the fixation of titanium implants by combining the surface technologies expertise of University of South Australia and Flinders University with TGR BioSciences's growth factors expertise. Plasma modified and hydroxyapatite-coated implant surfaces will be used for covalent immobilisation of growth factors via tethers with ....Covalent Immobilisation of Growth Factors on Plasma Modified Titanium for Achieving Enhanced Bone Growth and Bonding in Implant Prosthetics. This project is aimed at improving the fixation of titanium implants by combining the surface technologies expertise of University of South Australia and Flinders University with TGR BioSciences's growth factors expertise. Plasma modified and hydroxyapatite-coated implant surfaces will be used for covalent immobilisation of growth factors via tethers with tailored wettability and flexibility. This innovative strategy is expected to yield high retention of growth factor bioactivity and increased bone-implant integration for long-term implant stability. Knowledge, expertise and techniques developed will help TGR BioSciences expanding its research base and business. Training of students in the emerging field of nano-biotechnology will be another major outcome.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC170100016
Funder
Australian Research Council
Funding Amount
$3,123,492.00
Summary
ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therap ....ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therapeutics. The use of an individual patient’s cellular and molecular research findings will ultimately enable personalised diagnostic and therapeutic decisions.Read moreRead less