The Biology Of Staphylococcus Epidermidis Biofilm Formation On Silicone Implantable Medical Devices And The Role Of Implant Surface Antibiotic Technology In The Prevention Of Bacterial Biofilm In And Animal Model
Funder
National Health and Medical Research Council
Funding Amount
$113,322.00
Summary
Hospital acquired infections continue to rise with over 60% occuring in patients with medical implants. Infections are due to skin bacteria forming a microscopic slime, or biofilm, around the implant. Biofilm infection is only diagnosed after implant removal, responds poorly to antibiotics, and can cause implant failure, such as joint loosening & bone infection in joint replacements and breast deformity with silicone implants. This project uses an animal model to evaluate different surface treat ....Hospital acquired infections continue to rise with over 60% occuring in patients with medical implants. Infections are due to skin bacteria forming a microscopic slime, or biofilm, around the implant. Biofilm infection is only diagnosed after implant removal, responds poorly to antibiotics, and can cause implant failure, such as joint loosening & bone infection in joint replacements and breast deformity with silicone implants. This project uses an animal model to evaluate different surface treatments to prevent bacterial biofilm formation.Read moreRead less
Bacteriology Of Bronchiectasis In Australian Indigenous Children
Funder
National Health and Medical Research Council
Funding Amount
$91,209.00
Summary
Many Indigenous children in the Northern Territory suffer from a chronic lung condition called bronchiectasis. This disease causes a lot of illness and can lead to early death in adulthood. Little is known about how the disease starts and how it can be prevented, but many children are being treated with the antibiotic azithromycin. My project aims to find out which bacteria are associated with bronchiectasis, how azithromycin affects the bacteria, and whether it leads to antibiotic resistance.
Genomic Adaptation Of Pseudomonas Aeruginosa In The Cystic Fibrosis Airway
Funder
National Health and Medical Research Council
Funding Amount
$133,351.00
Summary
Pseudomonas aeruginosa (Pa) is an important respiratory pathogen in Cystic Fibrosis (CF) which causes substantial morbidity and mortality. Its genetic versatility enables it to thrive in a wide diversity of environment. This study aims to assess the genomic adaptation of the common Pa strains among the Australian CF patients during chronic infection and during intravenous antibiotics therapy. The study results can lead to development of novel treatment options for Pa infection in CF.