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Parasitic infections are a significant global health problem, resulting in more than a million deaths annually. Unfortunately there is no licensed vaccine available for any human parasitic infection, and in many cases current drugs suffer from issues of parasite drug resistance. To address this problem this project brings together leading researchers from the European Union, Brazil, and Australia to discover and develop new types of drugs for four major human parasitic diseases: schistosomiasis, ....Parasitic infections are a significant global health problem, resulting in more than a million deaths annually. Unfortunately there is no licensed vaccine available for any human parasitic infection, and in many cases current drugs suffer from issues of parasite drug resistance. To address this problem this project brings together leading researchers from the European Union, Brazil, and Australia to discover and develop new types of drugs for four major human parasitic diseases: schistosomiasis, leishmaniasis, Chagas disease and malaria.Read moreRead less
Dementia is the third leading cause of death in Australia and the single greatest cause of disability in the elderly. Current therapies for Alzheimer’s disease (AD), the most common form of dementia, are inadequate and fundamentally new treatment approaches are required. The aim of this proposal is to develop novel drug candidates for the treatment and prevention of AD and other neurodegenerative disorders by targeting a class of cell-surface receptors called G protein-coupled receptors (GPCRs).
Kidney Mesenchymal Stem Cells In Tubular Development, Repair And Turnover
Funder
National Health and Medical Research Council
Funding Amount
$989,141.00
Summary
In Australia, 11.3% of deaths are associated with chronic kidney disease with >$1 billion per annum spent on treating this condition. At present, only dialysis and transplantation are available to treat end stage kidney disease. We have found a kidney stem cell population in both human and mouse that can form new epithelial structures. In this project, we will investigate the normal role played by these kidney stem cells and examine whether they can contribute to kidney regeneration.
New Nanoparticle Strategies For Efficient Delivery And Controlled Release Into The Brain
Funder
National Health and Medical Research Council
Funding Amount
$571,633.00
Summary
A key challenge for treating neurodegenerative diseases is delivery of drugs across the blood–brain barrier (BBB). This project will develop advanced BBB “nanoshuttles” based upon systematic investigation of BBB penetration mechanisms and near-infrared drug controlled release strategy. These delivery systems may facilitate diagnosis of brain diseases and on-demand release of drug cargos to diseased cells in the brain, offering the potential of a brand new localised therapy for brain diseases.
Development And Epilepsy - Strategies For Innovative Research To Improve Diagnosis, Prevention And Treatment In Children With Difficult To Treat Epilepsy
Funder
National Health and Medical Research Council
Funding Amount
$456,083.00
Summary
By deciphering pathophysiological mechanisms in epileptogenic developmental disorders and developing mechanism-related, and advanced therapeutic strategies, we expect to discover novel genes and related molecular pathways that are involved in epilepsy and similar disorders. DESIRE will also help preventing the development of the disease after potentially epileptogenic brain insults.
Investigation Of Zinc Dyshomeostasis Associated With Aging And Dementia-related Disorders Using Novel Nanodiamond-based Markers
Funder
National Health and Medical Research Council
Funding Amount
$604,644.00
Summary
This project will illuminate the fundamental brain changes that lead to age-related cognitive decline by means of newly developed biamarker based on fluorescent nanodiamonds. The expected outcome of this work will be a unique approach to elucidate the source of cognitive decline that will fill a significant unmet need within the community.
Novel Antivirals For The Treatment Of Hendravirus Infection.
Funder
National Health and Medical Research Council
Funding Amount
$199,227.00
Summary
Hendravirus outbreaks have become frequent and 7 human cases have been reported, this has resulted in 4 deaths. Currently we have no treatment options. Researchers at Griffith University and the CSIRO have developed a new treatment that attacks the virus by turning off the viral genes at the site of infection. The plan is to treat patients soon after infection to slow or stop the virus and allow patients to recover naturally from this highly lethal disease.
Determining The Clinical Effectiveness Of Antiviral Drugs Against Oseltamivir- And Laninamivir-resistant Influenza Viruses In Animal Models
Funder
National Health and Medical Research Council
Funding Amount
$388,067.00
Summary
Currently, the neuraminidase inhibitors are the only drugs that are effective against seasonal influenza viruses. However, viruses can develop resistance to these drugs. Using viruses with varied levels of resistance, the project will determine the effectiveness of different drug treatments in animal models. This will lead to better treatment for those patients seriously ill with drug-resistant influenza viruses.
Improving The Health Of Older Australians At Risk Of Dementia - The Role Of Physical Function And Exercise
Funder
National Health and Medical Research Council
Funding Amount
$533,120.00
Summary
This fellowship will support novel research to examine whether exercise can improve the cognitive and physical health of individuals at risk of dementia such as those with Type 2 Diabetes or cognitive impairment. Outcomes are likely to delay the onset of dementia and enable older Australians at risk of dementia to maintain independence and improved quality of life.
Improving Mental Health And Social Participation Outcomes In Older Adults With Depression And Anxiety
Funder
National Health and Medical Research Council
Funding Amount
$791,581.00
Summary
This study will evaluate a comprehensive treatment program for older adults who are suffering depression and anxiety. We expect that this new treatment program will be more powerful than standard cognitive behavioural therapy. Through this treatment we will increase social participation and quality of life and reduce depression and anxiety in older Australians.