Preparing Australia For Genomic Medicine: A Proposal By The Australian Genomics Health Alliance
Funder
National Health and Medical Research Council
Funding Amount
$25,000,000.00
Summary
The sequencing of the human genome brings the possibility of more accurate identification of the underlying basis of many diseases. This technology has moved so rapidly, however, that clinical access has been limited. In this application, a national alliance of clinicians, researchers, health economists and policymakers will evaluate the case for clinical genomics across inherited disease and cancer, determine how best to deliver this to the patient and train a capable workforce.
Identifying technological trajectories using machine learning algorithms. This project aims to improve our understanding of why scientific knowledge progresses in certain directions and what causes it to grow faster or slower across fields. The project will create new neural-network machine-learning algorithms to scan patent and scientific article texts (specifications and claims) for natural language concepts. The results will potentially be used by patent offices to improve their own database ....Identifying technological trajectories using machine learning algorithms. This project aims to improve our understanding of why scientific knowledge progresses in certain directions and what causes it to grow faster or slower across fields. The project will create new neural-network machine-learning algorithms to scan patent and scientific article texts (specifications and claims) for natural language concepts. The results will potentially be used by patent offices to improve their own database search, by business analytics companies to reveal new technologies and potential collaborators, and by academic economists to understand how knowledge travels and accumulates.
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On effectively modelling and efficiently discovering communities from large networks. Finding and maintaining close communities from very large scale, dynamically changing networks is interesting and challenging. This project aims to develop new techniques to identify such communities as fast as possible through exploiting the rich semantics and individual relationships within the communities.
How enhancers regulate T cell differentiation and function. This project aims to identify the molecular mechanisms that regulate the activity of transcriptional enhancers needed for effective immune cell differentiation. Adaptive immune cell activation starts a programme of differentiation that acquires and maintains lineage-specific effector function. Using a multidisciplinary approach including cellular and chromatin biology, advanced bioinformatics, targeted genome editing and nanotechnology, ....How enhancers regulate T cell differentiation and function. This project aims to identify the molecular mechanisms that regulate the activity of transcriptional enhancers needed for effective immune cell differentiation. Adaptive immune cell activation starts a programme of differentiation that acquires and maintains lineage-specific effector function. Using a multidisciplinary approach including cellular and chromatin biology, advanced bioinformatics, targeted genome editing and nanotechnology, this project expects to provide insights into non-coding regulatory element reprogramming and control of immune cell function and memory with implications for understanding general cellular differentiation.Read moreRead less
Three-dimensional structure determination of biomolecular assemblies from sparse data of different length scales. New computer algorithms will be combined with sparse experimental structure restraints, obtained with novel protein chemistry technologies, to generate accurate three-dimensional (3D) models of proteins and protein assemblies in solution and in the solid state. The new strategies will greatly increase the number of protein targets amenable to rational drug design.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100143
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Flexible architecture high-performance computing facility for the intersect consortium of New South Wales. This new supercomputing facility is an important addition to the nation's research infrastructure and will enable world-leading, New South Wales researchers to continue their ground breaking work in increasingly competitive environments. Much of the research to be undertaken at the facility lies in areas of national priority, including frontier technologies and environmental sustainability.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100181
Funder
Australian Research Council
Funding Amount
$650,000.00
Summary
Strengthening merit-based access and support at the new National Computing Infrastructure petascale supercomputing facility. World-leading high-performance computing is fundamental to Australia's international research success. This facility will provide access to the new National Computational Infrastructure facility by world-leading researchers from six research universities, and sustain ground-breaking work in an increasingly competitive environment.
The endangered swift parrot as a model for managing small migratory birds. Endangered swift parrots use variable locations while breeding in eastern Tasmania and over winter on the Australian mainland. This project aims to develop effective conservation strategies for swift parrots and other migrants using new and long term data and innovative technological solutions to tracking small birds across vast landscapes.
Intercultural understanding in primary and secondary schools. What facilitates or impedes intercultural understanding in children, adolescents and schools? How can this be addressed? How can we know what makes a difference? This project answers these questions at the individual, school and national level using a novel cultural systems approach and methodological and technological innovations.
An approach to preserving accounting and business archival materials: enhancing accessibility to inform research and practice. CPA Australia is one of the oldest professional accounting associations in the world. Its archival records provide invaluable insights into the development of the profession and the business community it services. The preservation and management of this heritage will be of benefit not just to the profession but also in enhancing our understanding of the evolution of the ....An approach to preserving accounting and business archival materials: enhancing accessibility to inform research and practice. CPA Australia is one of the oldest professional accounting associations in the world. Its archival records provide invaluable insights into the development of the profession and the business community it services. The preservation and management of this heritage will be of benefit not just to the profession but also in enhancing our understanding of the evolution of the corporate foundation of the economy. This project will involve the development of a framework for managing the archive and facilitating access through the use of digital technologies. The outcomes will contribute to preserving and understanding the nation's business history as well as facilitating integration with international accounting and business archives.Read moreRead less