Cryptographic Protocols: Proofs and Designs. Cryptographic protocols are the foundation for protection of the critical electronic communications infrastructure on which much of commerce and industry rely. They will increasingly be required in emerging technologies such as ad-hoc wireless networks and sensor networks. This project will provide the ability to design new and efficient protocols with a mathematical guarantee of security. The resulting practical protocols will benefit all users of el ....Cryptographic Protocols: Proofs and Designs. Cryptographic protocols are the foundation for protection of the critical electronic communications infrastructure on which much of commerce and industry rely. They will increasingly be required in emerging technologies such as ad-hoc wireless networks and sensor networks. This project will provide the ability to design new and efficient protocols with a mathematical guarantee of security. The resulting practical protocols will benefit all users of electronic communications who require security for their information. This includes the financial industries, government, commerce and domestic users.Read moreRead less
Cryptographic Protocols from Pairings: Proofs and Designs. Modern society has become critically dependent on information and communications infrastructures. At the same time, the development of e-commerce is being slowed by lack of confidence in its security. By providing increased assurance and enhanced cryptographic security protocols this research will improve the dependability of the nation's information and communications infrastructure, as well as encourage the growth of e-commerce. Throu ....Cryptographic Protocols from Pairings: Proofs and Designs. Modern society has become critically dependent on information and communications infrastructures. At the same time, the development of e-commerce is being slowed by lack of confidence in its security. By providing increased assurance and enhanced cryptographic security protocols this research will improve the dependability of the nation's information and communications infrastructure, as well as encourage the growth of e-commerce. Through the expertise and experience gained with this project, Australia's excellence in information security research will be reinforced. The training of PhD and Honours students will provide a much needed source of highly trained information security professionals.Read moreRead less
Principles of Quantum Information Science. The use of quantum mechanical systems to carry and process information is enabling a revolution in information technology through innovations such as quantum computation and quantum teleportation. This project investigates the fundamental theory of quantum information science. The project aims to formulate general principles governing the power and behaviour of quantum information. These principles will, in turn, enable the development of powerful new ....Principles of Quantum Information Science. The use of quantum mechanical systems to carry and process information is enabling a revolution in information technology through innovations such as quantum computation and quantum teleportation. This project investigates the fundamental theory of quantum information science. The project aims to formulate general principles governing the power and behaviour of quantum information. These principles will, in turn, enable the development of powerful new applications of quantum information. Principal areas to be addressed include: general conditions for a physical system to be usable for quantum computation, the development of new algorithms for quantum computers, the development of new quantum communication protocols, and the theory of quantum entanglement.Read moreRead less
Algorithms and computation in four-dimensional topology. This project will establish Australia as a world leader in computational topology, particularly in the all-important areas of topology in three and four dimensions. In four dimensions this work will be truly groundbreaking; until now the field has seen little development due to the complexity of the algorithms and computations required, and the applicant is in the unique position of having the necessary tools to make significant progress ....Algorithms and computation in four-dimensional topology. This project will establish Australia as a world leader in computational topology, particularly in the all-important areas of topology in three and four dimensions. In four dimensions this work will be truly groundbreaking; until now the field has seen little development due to the complexity of the algorithms and computations required, and the applicant is in the unique position of having the necessary tools to make significant progress in a feasible time frame. In three dimensions this project will strengthen the distinguished computational topology community in Melbourne, led by pioneers such as Rubinstein, Goodman, Hodgson as well as the applicant himself.Read moreRead less
Preparing Australia For Genomic Medicine: A Proposal By The Australian Genomics Health Alliance
Funder
National Health and Medical Research Council
Funding Amount
$25,000,000.00
Summary
The sequencing of the human genome brings the possibility of more accurate identification of the underlying basis of many diseases. This technology has moved so rapidly, however, that clinical access has been limited. In this application, a national alliance of clinicians, researchers, health economists and policymakers will evaluate the case for clinical genomics across inherited disease and cancer, determine how best to deliver this to the patient and train a capable workforce.
Sequencing and assembling microbial community metagenomes in real-time. This project aims to assemble metagenomes directly from environmental samples using nanopore sequencing. Short-read approaches to metagenomics cannot assemble mixed genomes from an environmental sample, so focus on describing which species and genes are present. Long-read nanopore sequencing enables the assembly of full genomes of multiple species in a sample. Assembling complete genomes in important resources such as water ....Sequencing and assembling microbial community metagenomes in real-time. This project aims to assemble metagenomes directly from environmental samples using nanopore sequencing. Short-read approaches to metagenomics cannot assemble mixed genomes from an environmental sample, so focus on describing which species and genes are present. Long-read nanopore sequencing enables the assembly of full genomes of multiple species in a sample. Assembling complete genomes in important resources such as water and soil should lead to deeper understanding of the dynamics, variation and transfer of genetic material within these resources’ microbial communities, strategies to manage microbial diversity, and improved productivity and long-term sustainability for these resources.Read moreRead less
Understanding How Azithromycin Prevents Exacerbations In Severe Asthma
Funder
National Health and Medical Research Council
Funding Amount
$697,273.00
Summary
In some people with severe asthma, conventional inhaler treatments are not able to control the disease so there is a need for new treatment options. We have recently completed a large clinical trial which showed that very low doses of a common antibiotic help prevent asthma attacks in this situation. However, not much is known about how the antibiotic is working. This study will help us understand how the antibiotic is working and which people respond best.
Reconstructing proteins to explain and engineer biological diversity. The aim of this project is to develop computational methods to construct entirely new proteins. Computational reconstruction of enzymes that have been extinct for over 400 million years has revealed remarkable opportunities for biotechnological innovation. The intended outcomes are to develop bioinformatics methods to broaden the scope of ancestral protein reconstruction to include protein super-families, to establish what spe ....Reconstructing proteins to explain and engineer biological diversity. The aim of this project is to develop computational methods to construct entirely new proteins. Computational reconstruction of enzymes that have been extinct for over 400 million years has revealed remarkable opportunities for biotechnological innovation. The intended outcomes are to develop bioinformatics methods to broaden the scope of ancestral protein reconstruction to include protein super-families, to establish what specific changes led to the evolutionary success of a protein, and to re-run evolution to generate proteins that perform in conditions suitable for industrial and agricultural applications, in particular the production of hydroxylated fatty acids for bioplastics. By examining proteins from many life forms, the project plans to develop a novel bioinformatics strategy to understand their evolution and engineer new proteins for use in production of chemical commodities.Read moreRead less
Secure and Efficient Cryptographic Hashing. This project will enhance information security, which is absolutely crucial for rapidly growing e-commerce, e-government services and for national security (Priority 4 -Safeguarding Australia - Protection against Terrorism and Crime). The project will strengthen international collaboration by reciprocal exchange of researchers and postgraduate students leading to more attractive and productive research environment. At the same time, the project will he ....Secure and Efficient Cryptographic Hashing. This project will enhance information security, which is absolutely crucial for rapidly growing e-commerce, e-government services and for national security (Priority 4 -Safeguarding Australia - Protection against Terrorism and Crime). The project will strengthen international collaboration by reciprocal exchange of researchers and postgraduate students leading to more attractive and productive research environment. At the same time, the project will help to maintain high research profile of Australian researchers, to increase the capacity for consultancy and contract work, and provide a cutting-edge information technology for the Australian telecommunications industry, business and government (Priority 3 - Frontier Technologies). Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150101117
Funder
Australian Research Council
Funding Amount
$327,000.00
Summary
The functional impact of new genes acquired through retrotransposition. Novel copies of genes often arise through retrotransposition of processed messenger RNAs. Many thousands of gene copies have arisen over evolutionary time and some of these have retained functionality while diverging from the parental gene leading to new paralogs under different regulatory regimes. Through analysis of whole-genome sequence data, we are now able to identify very recent gene copies that are not present in the ....The functional impact of new genes acquired through retrotransposition. Novel copies of genes often arise through retrotransposition of processed messenger RNAs. Many thousands of gene copies have arisen over evolutionary time and some of these have retained functionality while diverging from the parental gene leading to new paralogs under different regulatory regimes. Through analysis of whole-genome sequence data, we are now able to identify very recent gene copies that are not present in the reference genomes for various species, giving us the opportunity to explore the effects of new copies on the regulation of the original gene and the surrounding genomic environment into which the new copy is inserted. This project aims to address these important open questions through computational and biochemical approaches.Read moreRead less