Genome evolution & adaptation of the multinuclear wheat stripe rust fungus. Animals and plants package their genomes into a single nucleus within each cell. In contrast, millions of fungal species accommodate multiple nuclei containing individual haploid genomes. It is currently unknown what the evolutionary implications are for this unusual genome division into multiple nuclei. Here we explore the evolutionary consequences of genome division into multiple nuclei for the first time by applying c ....Genome evolution & adaptation of the multinuclear wheat stripe rust fungus. Animals and plants package their genomes into a single nucleus within each cell. In contrast, millions of fungal species accommodate multiple nuclei containing individual haploid genomes. It is currently unknown what the evolutionary implications are for this unusual genome division into multiple nuclei. Here we explore the evolutionary consequences of genome division into multiple nuclei for the first time by applying cutting edge genome biology tools and algorithms. The economically significant study system is the devastating wheat stripe rust fungus. This pathogen costs Australian farmers over $100 million a year. New understanding is expected to lead to better disease management, reduced fungicide applications, and increased yields.Read moreRead less
Preparing Australia For Genomic Medicine: A Proposal By The Australian Genomics Health Alliance
Funder
National Health and Medical Research Council
Funding Amount
$25,000,000.00
Summary
The sequencing of the human genome brings the possibility of more accurate identification of the underlying basis of many diseases. This technology has moved so rapidly, however, that clinical access has been limited. In this application, a national alliance of clinicians, researchers, health economists and policymakers will evaluate the case for clinical genomics across inherited disease and cancer, determine how best to deliver this to the patient and train a capable workforce.
Identifying technological trajectories using machine learning algorithms. This project aims to improve our understanding of why scientific knowledge progresses in certain directions and what causes it to grow faster or slower across fields. The project will create new neural-network machine-learning algorithms to scan patent and scientific article texts (specifications and claims) for natural language concepts. The results will potentially be used by patent offices to improve their own database ....Identifying technological trajectories using machine learning algorithms. This project aims to improve our understanding of why scientific knowledge progresses in certain directions and what causes it to grow faster or slower across fields. The project will create new neural-network machine-learning algorithms to scan patent and scientific article texts (specifications and claims) for natural language concepts. The results will potentially be used by patent offices to improve their own database search, by business analytics companies to reveal new technologies and potential collaborators, and by academic economists to understand how knowledge travels and accumulates.
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COMPLEX NETWORKS: DYNAMICS, OPTIMIZATION AND CONTROL. Complex networks such large power grids, the Internet, transportation networks and co-operation networks of all kinds provide challenges for frontier technologies particularly computing, communication and control. In particular, advanced societies have become dependent on large infrastructure networks to an extent beyond our capability to plan and control them. The recent spate of collapses in power grids and virus attacks on the Internet i ....COMPLEX NETWORKS: DYNAMICS, OPTIMIZATION AND CONTROL. Complex networks such large power grids, the Internet, transportation networks and co-operation networks of all kinds provide challenges for frontier technologies particularly computing, communication and control. In particular, advanced societies have become dependent on large infrastructure networks to an extent beyond our capability to plan and control them. The recent spate of collapses in power grids and virus attacks on the Internet illustrate the need for research on modelling, analysis of behaviour, planning and control in such networks. This project aims to establish research in this area for Australia's benefit.Read moreRead less
Exploring the Frontiers of Feasible Computation. The project aims to delineate the boundary between feasible and infeasible computational problems. A problem is considered feasible if there is an algorithm to solve it in worst-case time bounded by a polynomial in the input size. This is probably impossible for the important class of NP-complete problems. However, typical examples of NP-complete problems can often be solved in polynomial time, because worst-case problems are rare. The project is ....Exploring the Frontiers of Feasible Computation. The project aims to delineate the boundary between feasible and infeasible computational problems. A problem is considered feasible if there is an algorithm to solve it in worst-case time bounded by a polynomial in the input size. This is probably impossible for the important class of NP-complete problems. However, typical examples of NP-complete problems can often be solved in polynomial time, because worst-case problems are rare. The project is relevant to public-key cryptography, where breaking an encryption scheme should be infeasible, and to many real-life situations where NP-complete problems need to be solved, either exactly or approximately.Read moreRead less
Multicast in Single-Hop and Multi-Hop WDM Optical Networks. The emerging Wavelength-Division-Multiplexing (WDM) optical network is a promising candidate for next-generation Internet, which provides enormous bandwidth and fast connectivity. Multicast in WDM networks is a fundamental problem which has wide applications including teleconferencing, entertainment distribution, etc. In this project we investigate the multicast and constraint multicast problems in both single-hop and multi-hop WDM netw ....Multicast in Single-Hop and Multi-Hop WDM Optical Networks. The emerging Wavelength-Division-Multiplexing (WDM) optical network is a promising candidate for next-generation Internet, which provides enormous bandwidth and fast connectivity. Multicast in WDM networks is a fundamental problem which has wide applications including teleconferencing, entertainment distribution, etc. In this project we investigate the multicast and constraint multicast problems in both single-hop and multi-hop WDM networks by studying their computational complexities and devising scalable, high-quality approximation algorithms for them. The developed algorithms significantly improve the network performance and scalability, and the innovative approaches and algorithm techniques developed in this project are also applicable to other routing problems.Read moreRead less
Dynamics and Security Control of Complex Networks. The research will yield basic techniques to analyse, design and operate complex networks so that security, as well as performance, is achieved. These techniques will be further developed towards particular applications including power grids and telecommunication networks. However, the emphasis is on providing basic ideas and techniques.
Reliable and Seamless Service Provisioning in Mobile Edge Computing . This project aims to develop enabling technologies to provide reliable and seamless services in mobile edge computing environments. This project will develop advanced algorithms with performance guarantees and efficient mechanisms for such service provisioning. The project expects to lay theoretical foundations and generate new knowledge for the provisioning of reliability-aware and mobility-aware services in mobile edge compu ....Reliable and Seamless Service Provisioning in Mobile Edge Computing . This project aims to develop enabling technologies to provide reliable and seamless services in mobile edge computing environments. This project will develop advanced algorithms with performance guarantees and efficient mechanisms for such service provisioning. The project expects to lay theoretical foundations and generate new knowledge for the provisioning of reliability-aware and mobility-aware services in mobile edge computing. The expected outcome of the project is a set of solutions to the myriad of services relying on mobile edge computing including e-Health, autonomous vehicles, and Internet of Things. This project will develop key fundamental technologies to improve Australia’s standing in the international research community.
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Service Provisioning for the Internet of Things in Mobile Edge Computing. This project aims to develop a suite of novel algorithms and enabling technologies for service provisioning of the Internet of Things (IoT) applications in mobile edge computing (MEC). This project will develop performance-guaranteed algorithms and core technologies for IoT service provisioning through effective cost modelling. The project expects to lay theoretical foundations, discover key principles and generate new kno ....Service Provisioning for the Internet of Things in Mobile Edge Computing. This project aims to develop a suite of novel algorithms and enabling technologies for service provisioning of the Internet of Things (IoT) applications in mobile edge computing (MEC). This project will develop performance-guaranteed algorithms and core technologies for IoT service provisioning through effective cost modelling. The project expects to lay theoretical foundations, discover key principles and generate new knowledge for IoT service provisioning in MEC. The expected outcome of the project is a suite of solutions to the myriad of IoT services in MEC including e-Health and autonomous vehicles. This project should also develop key fundamental technologies to improve Australia's standing in the international research community.Read moreRead less
Design Efficient Routing Protocols For WDM Optical Networks. The optical network technique plays a key role to the next-generation networks. In particular, wavelength-division-multiplexing (WDM) optical networks have emerged as a promising candidate for next-generation networks in providing huge available bandwidth and connectivity.
Routing and wavelength assignment problem is one of the fundamental problems in WDM optical networks. In this project we primarily focus on devising and analyzing ....Design Efficient Routing Protocols For WDM Optical Networks. The optical network technique plays a key role to the next-generation networks. In particular, wavelength-division-multiplexing (WDM) optical networks have emerged as a promising candidate for next-generation networks in providing huge available bandwidth and connectivity.
Routing and wavelength assignment problem is one of the fundamental problems in WDM optical networks. In this project we primarily focus on devising and analyzing efficient routing algorithms for all-to-all routing and robust routing in the WDM networks. Incorporated with various known techniques, practical algorithms will be developed. The algorithms and techniques developed in this project will be through simulation, testing, and implementation.Read moreRead less