Genome evolution & adaptation of the multinuclear wheat stripe rust fungus. Animals and plants package their genomes into a single nucleus within each cell. In contrast, millions of fungal species accommodate multiple nuclei containing individual haploid genomes. It is currently unknown what the evolutionary implications are for this unusual genome division into multiple nuclei. Here we explore the evolutionary consequences of genome division into multiple nuclei for the first time by applying c ....Genome evolution & adaptation of the multinuclear wheat stripe rust fungus. Animals and plants package their genomes into a single nucleus within each cell. In contrast, millions of fungal species accommodate multiple nuclei containing individual haploid genomes. It is currently unknown what the evolutionary implications are for this unusual genome division into multiple nuclei. Here we explore the evolutionary consequences of genome division into multiple nuclei for the first time by applying cutting edge genome biology tools and algorithms. The economically significant study system is the devastating wheat stripe rust fungus. This pathogen costs Australian farmers over $100 million a year. New understanding is expected to lead to better disease management, reduced fungicide applications, and increased yields.Read moreRead less
Multicast in Single-Hop and Multi-Hop WDM Optical Networks. The emerging Wavelength-Division-Multiplexing (WDM) optical network is a promising candidate for next-generation Internet, which provides enormous bandwidth and fast connectivity. Multicast in WDM networks is a fundamental problem which has wide applications including teleconferencing, entertainment distribution, etc. In this project we investigate the multicast and constraint multicast problems in both single-hop and multi-hop WDM netw ....Multicast in Single-Hop and Multi-Hop WDM Optical Networks. The emerging Wavelength-Division-Multiplexing (WDM) optical network is a promising candidate for next-generation Internet, which provides enormous bandwidth and fast connectivity. Multicast in WDM networks is a fundamental problem which has wide applications including teleconferencing, entertainment distribution, etc. In this project we investigate the multicast and constraint multicast problems in both single-hop and multi-hop WDM networks by studying their computational complexities and devising scalable, high-quality approximation algorithms for them. The developed algorithms significantly improve the network performance and scalability, and the innovative approaches and algorithm techniques developed in this project are also applicable to other routing problems.Read moreRead less
Dynamics and Security Control of Complex Networks. The research will yield basic techniques to analyse, design and operate complex networks so that security, as well as performance, is achieved. These techniques will be further developed towards particular applications including power grids and telecommunication networks. However, the emphasis is on providing basic ideas and techniques.
Reliable and Seamless Service Provisioning in Mobile Edge Computing . This project aims to develop enabling technologies to provide reliable and seamless services in mobile edge computing environments. This project will develop advanced algorithms with performance guarantees and efficient mechanisms for such service provisioning. The project expects to lay theoretical foundations and generate new knowledge for the provisioning of reliability-aware and mobility-aware services in mobile edge compu ....Reliable and Seamless Service Provisioning in Mobile Edge Computing . This project aims to develop enabling technologies to provide reliable and seamless services in mobile edge computing environments. This project will develop advanced algorithms with performance guarantees and efficient mechanisms for such service provisioning. The project expects to lay theoretical foundations and generate new knowledge for the provisioning of reliability-aware and mobility-aware services in mobile edge computing. The expected outcome of the project is a set of solutions to the myriad of services relying on mobile edge computing including e-Health, autonomous vehicles, and Internet of Things. This project will develop key fundamental technologies to improve Australia’s standing in the international research community.
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Service Provisioning for the Internet of Things in Mobile Edge Computing. This project aims to develop a suite of novel algorithms and enabling technologies for service provisioning of the Internet of Things (IoT) applications in mobile edge computing (MEC). This project will develop performance-guaranteed algorithms and core technologies for IoT service provisioning through effective cost modelling. The project expects to lay theoretical foundations, discover key principles and generate new kno ....Service Provisioning for the Internet of Things in Mobile Edge Computing. This project aims to develop a suite of novel algorithms and enabling technologies for service provisioning of the Internet of Things (IoT) applications in mobile edge computing (MEC). This project will develop performance-guaranteed algorithms and core technologies for IoT service provisioning through effective cost modelling. The project expects to lay theoretical foundations, discover key principles and generate new knowledge for IoT service provisioning in MEC. The expected outcome of the project is a suite of solutions to the myriad of IoT services in MEC including e-Health and autonomous vehicles. This project should also develop key fundamental technologies to improve Australia's standing in the international research community.Read moreRead less
Design Efficient Routing Protocols For WDM Optical Networks. The optical network technique plays a key role to the next-generation networks. In particular, wavelength-division-multiplexing (WDM) optical networks have emerged as a promising candidate for next-generation networks in providing huge available bandwidth and connectivity.
Routing and wavelength assignment problem is one of the fundamental problems in WDM optical networks. In this project we primarily focus on devising and analyzing ....Design Efficient Routing Protocols For WDM Optical Networks. The optical network technique plays a key role to the next-generation networks. In particular, wavelength-division-multiplexing (WDM) optical networks have emerged as a promising candidate for next-generation networks in providing huge available bandwidth and connectivity.
Routing and wavelength assignment problem is one of the fundamental problems in WDM optical networks. In this project we primarily focus on devising and analyzing efficient routing algorithms for all-to-all routing and robust routing in the WDM networks. Incorporated with various known techniques, practical algorithms will be developed. The algorithms and techniques developed in this project will be through simulation, testing, and implementation.Read moreRead less
Sparse grid approximations and fitting using generalised combination techniques. Sparse grid techniques provide an effective tool to deal with the
computational curse of dimensionality which is a constant challenge in
modelling complex data. The proposed research is aimed at the
development and analysis of algorithms for data fitting with sparse
grids using variants of the combination technique. The outcome of the
research is a theory which will provide insights in the applicability,
limit ....Sparse grid approximations and fitting using generalised combination techniques. Sparse grid techniques provide an effective tool to deal with the
computational curse of dimensionality which is a constant challenge in
modelling complex data. The proposed research is aimed at the
development and analysis of algorithms for data fitting with sparse
grids using variants of the combination technique. The outcome of the
research is a theory which will provide insights in the applicability,
limitations and the convergence properties of the proposed
algorithms. The outcomes will be widely applicable in modelling of
large scale and complex data as is encountered in areas of
bioinformatics, physics and experimental studies of complex systems.
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On effectively modelling and efficiently discovering communities from large networks. Finding and maintaining close communities from very large scale, dynamically changing networks is interesting and challenging. This project aims to develop new techniques to identify such communities as fast as possible through exploiting the rich semantics and individual relationships within the communities.
RNA-binding proteins rewire transcriptomes in immune cell differentiation. This project aims to combine advanced computational and experimental techniques to investigate a new layer of gene regulation by novel RNA binding proteins (RBP) which control messenger RNA length in immune cells. This project expects to demonstrate that these RBPs have a profound effect on immune cell differentiation and response to infection. Expected outcomes include the discovery of new RBPs regulating immunity, with ....RNA-binding proteins rewire transcriptomes in immune cell differentiation. This project aims to combine advanced computational and experimental techniques to investigate a new layer of gene regulation by novel RNA binding proteins (RBP) which control messenger RNA length in immune cells. This project expects to demonstrate that these RBPs have a profound effect on immune cell differentiation and response to infection. Expected outcomes include the discovery of new RBPs regulating immunity, with mechanism and function determined by novel CRISPR editing of a transgenic mouse model. The significant benefit will be a more complete understanding of RNA mechanisms of immune response, which will be critical in informing future advances in the rapidly developing areas of RNA-based biotechnologies and synthetic immunology.Read moreRead less
How enhancers regulate T cell differentiation and function. This project aims to identify the molecular mechanisms that regulate the activity of transcriptional enhancers needed for effective immune cell differentiation. Adaptive immune cell activation starts a programme of differentiation that acquires and maintains lineage-specific effector function. Using a multidisciplinary approach including cellular and chromatin biology, advanced bioinformatics, targeted genome editing and nanotechnology, ....How enhancers regulate T cell differentiation and function. This project aims to identify the molecular mechanisms that regulate the activity of transcriptional enhancers needed for effective immune cell differentiation. Adaptive immune cell activation starts a programme of differentiation that acquires and maintains lineage-specific effector function. Using a multidisciplinary approach including cellular and chromatin biology, advanced bioinformatics, targeted genome editing and nanotechnology, this project expects to provide insights into non-coding regulatory element reprogramming and control of immune cell function and memory with implications for understanding general cellular differentiation.Read moreRead less