I am a molecular and cellular biologist determining the molecular mechanisms responsible for the neurodegeneration in Alzheimer’s, Parkinson’s and Prion disease.
I am a neuroscientist-biochemist-cell biologist determining the mechanisms by which lipids and lipid transporters regulate neurodegeneration and vascular disease. I have recently developed a prototype drug that shows promise as a novel therapeutic approach for Alzheimer's disease.
Professor Ashley Bush has extensively researched the contribution of metal biochemistry to Alzheimer�s and Parkinson�s diseases. In the current proposal he will lead the clinical testing of a new drug that combats the abnormal accumulation of metals in Alzheimer�s brain pathology, he will search for abnormal metal-interactions with blood proteins as a potential predictive test, and he will study the roles of various brain proteins in regulating metal levels to maintain healthy function.