Genetic Investigations For Prodromal Alzheimer’s Disease
Funder
National Health and Medical Research Council
Funding Amount
$719,374.00
Summary
The disease process in Alzheimer’s disease (AD) begins decades before a diagnosis is made. We urgently need to investigate this pre-symptomatic stage to learn how the disease process begins, and allow the development of treatments that work before the brain is irreparably damaged. I will use genetic risk factors for AD to predict who is most at risk of developing AD. I will look for early changes and easily accessible markers, including the use of state of the art brain imaging.
Element Labeling Antibodies For Bio-imaging Of Proteins: A Case Study Of Beta-amyloid In Alzheimer's Disease Mouse Models
Funder
National Health and Medical Research Council
Funding Amount
$221,136.00
Summary
This project will develop new analytical methods for quantitative in-situ imaging of beta-amyloid in mouse brains. Beta-amyloid deposition in the brain is associated with Alzheimer�s disease. It is also planned to simultaneously image metal ions, which are also implicated in the deposition of beta-amyloid. Application of these novel methods to Alzheimer�s disease mouse models will provide new knowledge and significant insights into the aetiology of Alzheimer�s disease by determining the relation ....This project will develop new analytical methods for quantitative in-situ imaging of beta-amyloid in mouse brains. Beta-amyloid deposition in the brain is associated with Alzheimer�s disease. It is also planned to simultaneously image metal ions, which are also implicated in the deposition of beta-amyloid. Application of these novel methods to Alzheimer�s disease mouse models will provide new knowledge and significant insights into the aetiology of Alzheimer�s disease by determining the relationship between amyloid proteins and metal ions.Read moreRead less
A New Approach To Explore The Role Of Selenoproteins In Health And Disease
Funder
National Health and Medical Research Council
Funding Amount
$374,284.00
Summary
Selenoproteins play an important role in a variety of major diseases. Yet knowledge of the biology of selenium and its role in disease prevention and progression is not sufficient to recommend selenium supplementation for disease prevention or treatment. The broad aim of this research is to identify and characterise the response of selenoproteins to selenium supplementation and disease states.
The Role Of Peripheral Blood MicroRNAs As Biomarkers Of Alzheimer’s Disease
Funder
National Health and Medical Research Council
Funding Amount
$83,284.00
Summary
To investigate the role of microRNAs as biomarkers for Alzheimer's disease (AD) to allow for early diagnosis prior to the onset of clinically apparent memory decline. MicroRNA expression levels in blood samples from patients with AD, mild cognitive impairment and normal cognition will be assessed in order to determine potential biomarker candidates.
A Novel Intracellular Roadblock To Cobalamin Utilization In Ageing And Alzheimer�s Disease
Funder
National Health and Medical Research Council
Funding Amount
$11,304.00
Summary
Vitamin B12 is required for red blood cell formation, DNA synthesis and normal neurological function. B12 deficiency contributes to age-related cognitive decline and Alzheimer�s disease. This research will provide important new information regarding the ageing process and the impact that brain changes associated with ageing and Alzheimer's disease have on B12 metabolism. It will provide important information related to the therapeutic potential of B12.
Disentangling Aphasic Syndromes In Alzheimer's Disease
Funder
National Health and Medical Research Council
Funding Amount
$682,936.00
Summary
Alzheimer’s disease, the main cause of disability in older Australians, can present with diverse and complex manifestations. Language disturbances are not entirely characterised and raises diagnostic difficulties. By development of novel clinical tools and cutting-edge structural brain imaging, this project aims to refine the spectrum of language disturbances, analyse the pattern of brain atrophy and investigate susceptibility factors across Alzheimer's presentations.
Investigating The Iron Proteome In Alzheimer’s Disease
Funder
National Health and Medical Research Council
Funding Amount
$514,644.00
Summary
Iron is essential for brain function. When the delicate balance of metals in the brain is disturbed, neurodegenerative effects such as those seen in Alzheimer’s disease are observed. Although we know there is a link between iron and Alzheimer’s disease, we do not know which specific iron proteins are involved. This project will provide the first characterisation of different iron proteins in the brain to understand the mechanisms of disease and help in the search for new treatments.
Understanding The Experience Of Making Decisions For Persons With Dementia And Their Carers
Funder
National Health and Medical Research Council
Funding Amount
$71,110.00
Summary
This project aims to explore concepts of value, meaning, and experience of the diagnosis amongst sufferers of dementia through discussion of their approach to making care decisions, and reflection on how this dialogue has been conducted with others. These concepts will be assessed from the perspective of diagnosed sufferers, their primary carers and their diagnosing doctors.
Speech Impairment In Frontotemporal Dementia And Primary Progressive Aphasia
Funder
National Health and Medical Research Council
Funding Amount
$50,888.00
Summary
This research project aims to inform our understanding of the characteristics and trajectory of speech difficulties in frontotemporal dementia and primary progressive aphasia, two forms of younger onset dementia. Understanding the changes to speech that occur will assist with the early diagnosis of these disorders and improve measurement of disease progression. Findings will positively influence patient care through the identification of treatment targets and improved knowledge of prognosis.