Iron and phosphorus recovery from ferric precipitation sludge. To minimise health risks and environmental pollution, water and wastewater treatment processes often use iron salts to eliminate phosphate and other pollutants. This generates large amounts of chemical sludge that is typically sent to landfill. The benefits of this new process will be the recovery of both the iron, which can be reused in the process, and the phosphate, which is a key component in fertiliser. Since phosphate is a limi ....Iron and phosphorus recovery from ferric precipitation sludge. To minimise health risks and environmental pollution, water and wastewater treatment processes often use iron salts to eliminate phosphate and other pollutants. This generates large amounts of chemical sludge that is typically sent to landfill. The benefits of this new process will be the recovery of both the iron, which can be reused in the process, and the phosphate, which is a key component in fertiliser. Since phosphate is a limited natural resource with an increasingly high value, the recovery and recycling of this critical element in food production is highly important. The process will also avoid a large part of the sludge production and will make the water treatment processes more cost-effective.Read moreRead less
Development of an effective vaccine for chlamydial infection: optimisation of a non-toxic cholera toxin-based adjuvant to generate a protective mucosal response. Chlamydial genital infections are the most common sexually transmitted infection in Australia and the world and impose a major health burden on the community. Chlamydial infections are also associated with cardiovascular disease, Australia's biggest killer and asthma, another condition that has increased significantly in prevalence in t ....Development of an effective vaccine for chlamydial infection: optimisation of a non-toxic cholera toxin-based adjuvant to generate a protective mucosal response. Chlamydial genital infections are the most common sexually transmitted infection in Australia and the world and impose a major health burden on the community. Chlamydial infections are also associated with cardiovascular disease, Australia's biggest killer and asthma, another condition that has increased significantly in prevalence in the past 10 years. This project will evaluate the effectiveness of a new adjuvant as a first step towards the development of a vaccine to target these important infections.Read moreRead less
The Role of RNA interference in the induction of immune responses. Our work will allow us to understand a new means by which to alert the immune system to the presence of cancer cells using a new technology called RNA interference. This will hopefully lead to new investment in biotechnology products based on RNA interference, improved treatments for cancers and better health for Australians
The development of tyrosine kinase inhibitors for the treatment of inflammation and malignant disease. Through the combination of expertise from the Industry partner and the Hume group this project aims to develop specific inhibitors of the CSF-1 receptor protein tyrosine kinase in order to demonstrate their efficacy as modulators of CSF-1 dependent macrophage and tumour cell function in vitro. The expected outcome will be a lead set of targets which can be further assessed for therapeutic pote ....The development of tyrosine kinase inhibitors for the treatment of inflammation and malignant disease. Through the combination of expertise from the Industry partner and the Hume group this project aims to develop specific inhibitors of the CSF-1 receptor protein tyrosine kinase in order to demonstrate their efficacy as modulators of CSF-1 dependent macrophage and tumour cell function in vitro. The expected outcome will be a lead set of targets which can be further assessed for therapeutic potential in clinical trials.Read moreRead less
The development of a rapid diagnostic test for heparanase activity. Heparanase is an enzyme that has been implicated in a number of disease states such as cancer, arthritis, multiple sclerosis and other inflammatory diseases. Characterisation of this enzyme has been slow, due in part to the lack of a reliable direct activity assay. Using a multi-disciplinary approach, this project seeks to establish a rapid assay that will provide easy determination of heparanase activity. Furthermore, this a ....The development of a rapid diagnostic test for heparanase activity. Heparanase is an enzyme that has been implicated in a number of disease states such as cancer, arthritis, multiple sclerosis and other inflammatory diseases. Characterisation of this enzyme has been slow, due in part to the lack of a reliable direct activity assay. Using a multi-disciplinary approach, this project seeks to establish a rapid assay that will provide easy determination of heparanase activity. Furthermore, this assay could provide a useful diagnostic tool in a clinical environment that would allow for the rapid assessment of these diseases, their progression and indeed response to therapy.Read moreRead less
Ehanced Hydrodynamic Fractionation of Particles. The coal industry, which is a major contributor to the Australian economy, urgently needs a new washability method following its decision to abandon the existing laboratory standard. The existing method relies on the use of heavy organic liquids which are known to be toxic to human health. The 'water-based' approach proposed in this study overcomes the problem of risk to human health, thus benefiting Australian workers, the immediate industry, and ....Ehanced Hydrodynamic Fractionation of Particles. The coal industry, which is a major contributor to the Australian economy, urgently needs a new washability method following its decision to abandon the existing laboratory standard. The existing method relies on the use of heavy organic liquids which are known to be toxic to human health. The 'water-based' approach proposed in this study overcomes the problem of risk to human health, thus benefiting Australian workers, the immediate industry, and wider community. New separation technologies that could benefit the minerals industries and other key industries should follow. The project will also result in the education and training of two postgraduate students, and the advancement of two postdoctoral researchers in this area of industry. Read moreRead less
Microbial fuel cells for nutrient recovery from source-separated urine. This project aims to reduce the strain on urban wastewater treatment plants by removing and recovering nutrients from water collected in residential and commercial buildings. Urban wastewater treatment plants in Australia are under pressure from increasing population and urbanisation, and there are also ever stricter environmental regulations on discharge of nutrients (mainly nitrogen and phosphorus) into receiving waters. W ....Microbial fuel cells for nutrient recovery from source-separated urine. This project aims to reduce the strain on urban wastewater treatment plants by removing and recovering nutrients from water collected in residential and commercial buildings. Urban wastewater treatment plants in Australia are under pressure from increasing population and urbanisation, and there are also ever stricter environmental regulations on discharge of nutrients (mainly nitrogen and phosphorus) into receiving waters. With many plants operating close to capacity, water utilities may face large expenditure to increase the capacity of existing treatment facilities. This project proposes an alternative solution: decentralised removal and recovery of nutrients from urine separated at the source. It is planned that novel microbial fuel cell technology will be developed to deliver an economical solution, which will additionally generate valuable fertiliser as a by-product.Read moreRead less
Adsorption on activated alumina: mitigating fouling of water treatment processes caused by deposition of silica, organics and hardness ions. Coal seam gas offers tremendous economic potential but development of gas reserves will generate considerable quantities of saline water. This project will develop activated alumina technology for the removal of silica and organics from these waters to enable the industry to use evaporative technologies to reduce water volumes.
Biosolid flow, separation and activity in anaerobic lagoons. This project aims to develop a fundamental model of the complex, non-steady state flow behaviour in anaerobic lagoons. The project will develop new operating procedures and designs for large municipal, industrial and agricultural anaerobic lagoons. This will improve the efficiency of anaerobic digestion and reduce wastewater treatment costs, as well as increase renewable and sustainable biogas production. The intended outcome is a va ....Biosolid flow, separation and activity in anaerobic lagoons. This project aims to develop a fundamental model of the complex, non-steady state flow behaviour in anaerobic lagoons. The project will develop new operating procedures and designs for large municipal, industrial and agricultural anaerobic lagoons. This will improve the efficiency of anaerobic digestion and reduce wastewater treatment costs, as well as increase renewable and sustainable biogas production. The intended outcome is a validated 3D model that captures the physical and biological complexities of anaerobic lagoons. This will impact the design and operation of partner organisation lagoons, reducing capital and operating costs and improving biogas production.Read moreRead less
An evaluation of the environmental health risk of heatwaves associated with global warming. Global warming is associated with an increased frequency of severe weather events including frequent and severe heatwaves. Previous studies have demonstrated that heatwaves are amongst the most deadly disasters to affect the community. This study will identify those members of the community who are most at risk from heatwaves so that strategies may be identified and implemented by governments to protect t ....An evaluation of the environmental health risk of heatwaves associated with global warming. Global warming is associated with an increased frequency of severe weather events including frequent and severe heatwaves. Previous studies have demonstrated that heatwaves are amongst the most deadly disasters to affect the community. This study will identify those members of the community who are most at risk from heatwaves so that strategies may be identified and implemented by governments to protect those people during severe heatwave conditions. The direct benefit to the community will be reduced mortality and morbidity and the consequential reductions in the cost of community and health support services.Read moreRead less