How enhancers regulate T cell differentiation and function. This project aims to identify the molecular mechanisms that regulate the activity of transcriptional enhancers needed for effective immune cell differentiation. Adaptive immune cell activation starts a programme of differentiation that acquires and maintains lineage-specific effector function. Using a multidisciplinary approach including cellular and chromatin biology, advanced bioinformatics, targeted genome editing and nanotechnology, ....How enhancers regulate T cell differentiation and function. This project aims to identify the molecular mechanisms that regulate the activity of transcriptional enhancers needed for effective immune cell differentiation. Adaptive immune cell activation starts a programme of differentiation that acquires and maintains lineage-specific effector function. Using a multidisciplinary approach including cellular and chromatin biology, advanced bioinformatics, targeted genome editing and nanotechnology, this project expects to provide insights into non-coding regulatory element reprogramming and control of immune cell function and memory with implications for understanding general cellular differentiation.Read moreRead less
New guardians of the mucosa: Molecular characterisation of M cell biology. We aim to completely define the cellular and molecular biology of gut and lung M cells for the first time. We will elucidate how they develop, are regulated and function at a molecular level, and how M cells maintain normal gut and lung tissues and induce immune responses to protect against microbial challenges. In the future, the new insights will be essential pre-requisites for the development of mucosal-based intervent ....New guardians of the mucosa: Molecular characterisation of M cell biology. We aim to completely define the cellular and molecular biology of gut and lung M cells for the first time. We will elucidate how they develop, are regulated and function at a molecular level, and how M cells maintain normal gut and lung tissues and induce immune responses to protect against microbial challenges. In the future, the new insights will be essential pre-requisites for the development of mucosal-based interventions and vaccines that protect the gut and lung from infectious and inflammatory issues. The harnessing of effective immune responses to control such challenges, are of enormous fundamental and long-standing biological interest, and are amongst the most important areas of current scientific research.Read moreRead less
Identifying novel, health-related predictors of recidivism: Informing evidence-based throughcare. Throughcare is a policy priority for correctional authorities in Australia, however the evidence base to inform policy is limited. Using innovative modelling techniques and unique data from a large, representative cohort of ex-prisoners in Queensland, this study will: identify novel, health-related predictors of recidivism in the first two years after release from adult custody; examine the extent t ....Identifying novel, health-related predictors of recidivism: Informing evidence-based throughcare. Throughcare is a policy priority for correctional authorities in Australia, however the evidence base to inform policy is limited. Using innovative modelling techniques and unique data from a large, representative cohort of ex-prisoners in Queensland, this study will: identify novel, health-related predictors of recidivism in the first two years after release from adult custody; examine the extent to which risk and protective factors for recidivism vary over time and according to individual characteristics; and, provide evidence-based recommendations to improve throughcare interventions and reduce recidivism.Read moreRead less
A molecular investigation into the naïve T cell repertoire. This project aims to interrogate the relationship between T cell receptor (TCR) recognition modes and T cell recruitment and activation. CD8+ T cells are important for adaptive immunity. Their recognition, via TCR, of peptides bound to MHC class I antigen-presenting molecules (pMHCI), initiates a signalling cascade which activates T cells effector functions. All structural information on TCR recognition of pMHCI is based on TCRs prevale ....A molecular investigation into the naïve T cell repertoire. This project aims to interrogate the relationship between T cell receptor (TCR) recognition modes and T cell recruitment and activation. CD8+ T cells are important for adaptive immunity. Their recognition, via TCR, of peptides bound to MHC class I antigen-presenting molecules (pMHCI), initiates a signalling cascade which activates T cells effector functions. All structural information on TCR recognition of pMHCI is based on TCRs prevalent in immune responses, and all recognise pMHCI using a conserved orientation. This project aims to use this observation to study the relationship between TCR recognition modes and T cell recruitment and activation.Read moreRead less
Investigating the molecular basis of T-cell receptor cross-reactivity. This project will explore the basis of unexpected immune reactions whereby the immune system mistakes one molecular structure for another, a phenomenon known as cross-reactivity. This project will examine how often this is due to molecular mimicry, potentially explaining why immune T cells sometimes react inappropriately to different agents.
Parole in crisis? Public opinion on the use of parole. Serious crimes committed by parolees in Australia have brought parole into the public eye. Without concrete evidence, governments often act on the assumption that the public holds punitive attitudes. This project is expected to develop an evidence base to inform policy on parole at a crucial time when governments are under pressure to restrict its use. Three mixed-method studies aim to assess: what public views on parole are; why the public ....Parole in crisis? Public opinion on the use of parole. Serious crimes committed by parolees in Australia have brought parole into the public eye. Without concrete evidence, governments often act on the assumption that the public holds punitive attitudes. This project is expected to develop an evidence base to inform policy on parole at a crucial time when governments are under pressure to restrict its use. Three mixed-method studies aim to assess: what public views on parole are; why the public holds these views; and what influence these views have on policy and practice. The project is expected to make contributions to: creating information strategies that properly inform the public; supporting prisoner reintegration strategies; and shaping criminal justice policies based on informed community feedback.Read moreRead less
Novel concepts for bioelectrochemical generation of renewable fuels and chemicals from wastewater. Global warming and the diminishing fossil fuel resources are posing an ever increasing threat to our societies and economies. This project aims to develop novel and highly innovative bioelectrochemical processes for the production of valuable fuels and chemicals from wastewater, which is a largely untapped renewable resource.
Bio-electrochemical sulfate reduction and sulfur recovery without external carbon source. Highly acidic waterways and mining wastewaters create major environmental challenges in inland Australia. This project will use novel, solar driven biological processes to remove the acid and metals from these streams and enable beneficial reuse of the water and other resources recovered in the process.