Characterisation of nanobubbles. Surprisingly, nano-sized bubbles have recently been found to exist in aqueous solutions. Classical theory tells us they should rapidly dissolve, yet they are stable for several days, a phenomenon which has only recently been explained. Despite this, nanobubbles are already used in cleaning processes and appear to have significant health benefits. They are being investigated in treatments for asthma and neurodegenerative diseases. In collaboration with a pharmaceu ....Characterisation of nanobubbles. Surprisingly, nano-sized bubbles have recently been found to exist in aqueous solutions. Classical theory tells us they should rapidly dissolve, yet they are stable for several days, a phenomenon which has only recently been explained. Despite this, nanobubbles are already used in cleaning processes and appear to have significant health benefits. They are being investigated in treatments for asthma and neurodegenerative diseases. In collaboration with a pharmaceutical company, the best means to produce and characterise nanobubbles will be investigated, as well as the conditions governing their stability. The project also aims to determine how the nanobubbles interact with surfaces in order to better control their properties and achieve a better understanding of these bubbles.Read moreRead less
The epigenetic blueprint for T cell differentiation: a genomic view. A cardinal feature of adaptive immune cell activation is the initiation of a program of differentiation that results in acquisition and long term maintenance of lineage-speci?c effector function. This proposal aims to map and dissect genome wide molecular changes that occur at different stages of immune cell differentiation and identify key factors that regulating these changes. It is expected that distinct genomic signatures, ....The epigenetic blueprint for T cell differentiation: a genomic view. A cardinal feature of adaptive immune cell activation is the initiation of a program of differentiation that results in acquisition and long term maintenance of lineage-speci?c effector function. This proposal aims to map and dissect genome wide molecular changes that occur at different stages of immune cell differentiation and identify key factors that regulating these changes. It is expected that distinct genomic signatures, and the mechanisms indicative of effective immune cell differentiation will be identified. This proposal will provide insights into key mechanisms that result in reprogramming of immune cell function and memory and have implications for understanding general cellular differentiation.Read moreRead less
How enhancers regulate T cell differentiation and function. This project aims to identify the molecular mechanisms that regulate the activity of transcriptional enhancers needed for effective immune cell differentiation. Adaptive immune cell activation starts a programme of differentiation that acquires and maintains lineage-specific effector function. Using a multidisciplinary approach including cellular and chromatin biology, advanced bioinformatics, targeted genome editing and nanotechnology, ....How enhancers regulate T cell differentiation and function. This project aims to identify the molecular mechanisms that regulate the activity of transcriptional enhancers needed for effective immune cell differentiation. Adaptive immune cell activation starts a programme of differentiation that acquires and maintains lineage-specific effector function. Using a multidisciplinary approach including cellular and chromatin biology, advanced bioinformatics, targeted genome editing and nanotechnology, this project expects to provide insights into non-coding regulatory element reprogramming and control of immune cell function and memory with implications for understanding general cellular differentiation.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100001
Funder
Australian Research Council
Funding Amount
$875,000.00
Summary
A 3-photon imaging system for deep live imaging. This project aims to establish Australia’s first 3-photon microscope system with adaptive optics for deep intravital imaging. This advanced imaging system will enable researchers to investigate the biology of cells and tissue structures in a wide range of organs and engineered tissues, to a degree not possible with existing technology. This project will capitalise on advanced laser, microscope and adaptive optics technologies with the expected out ....A 3-photon imaging system for deep live imaging. This project aims to establish Australia’s first 3-photon microscope system with adaptive optics for deep intravital imaging. This advanced imaging system will enable researchers to investigate the biology of cells and tissue structures in a wide range of organs and engineered tissues, to a degree not possible with existing technology. This project will capitalise on advanced laser, microscope and adaptive optics technologies with the expected outcomes to include the generation of new knowledge of major biological systems, including the immune system and the nervous system. This will provide significant benefits to fundamental interdisciplinary research into immunology, infectious disease, neuroscience, mechanobiology and engineering.Read moreRead less
microRNAs and the control of T lymphocyte differentiation, function and malignant transformation. The molecular mechanism of the immune system is not completely understood. This project will investigate how transcription factors and microRNAs, two major types of regulatory molecules work together to control immune responses. The results from this research will assist in the design of better vaccination strategies and treat certain lymphomas.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100193
Funder
Australian Research Council
Funding Amount
$590,000.00
Summary
Next Generation Mass Spectrometry for Analysis of Biomolecules. Next-generation mass spectrometry for analysis of biomolecules:
This project seeks to establish a next-generation mass spectrometer that represents the most sensitive, accurate and rapid mass spectrometer allowing the simultaneous quantitation of several hundred to several thousand proteins in a single experiment. This is designed to particularly support infection and immunity research. Novel fragmentation capabilities and enhanced ....Next Generation Mass Spectrometry for Analysis of Biomolecules. Next-generation mass spectrometry for analysis of biomolecules:
This project seeks to establish a next-generation mass spectrometer that represents the most sensitive, accurate and rapid mass spectrometer allowing the simultaneous quantitation of several hundred to several thousand proteins in a single experiment. This is designed to particularly support infection and immunity research. Novel fragmentation capabilities and enhanced workflows on this instrument may allow new types of experiments to be conducted providing significant improvements in coverage and depth of analysis.Read moreRead less
Understanding and responding to online child sexual exploitation offenders. The development of online communication technologies has facilitated a growth in online child sexual exploitation over the past two decades. Using a data-linkage framework, this project aims to enhance understanding of online child sexual exploitation, the legal frameworks surrounding this issue, and the unique characteristics, risks and needs of online sexual offenders. Expected outcomes include increased knowledge to i ....Understanding and responding to online child sexual exploitation offenders. The development of online communication technologies has facilitated a growth in online child sexual exploitation over the past two decades. Using a data-linkage framework, this project aims to enhance understanding of online child sexual exploitation, the legal frameworks surrounding this issue, and the unique characteristics, risks and needs of online sexual offenders. Expected outcomes include increased knowledge to inform current law enforcement and sentencing practices and the development of risk assessment and intervention protocols for clinical use with online offenders. This should increase evidence-based practice with online sexual offenders and assist in preventing the sexual exploitation of children online and in the community.Read moreRead less
Understanding Australia by analysing wastewater during the Census 2021 . This project aims to utilise the Australian Census 2021, a unique opportunity to link exposure to chemical and biological hazards with catchment socio-demographic data via systematic wastewater analysis. The project is expected to advance our capabilities to identify emerging hazards and understand factors that affect spatiotemporal trends in hazards across Australia. Moreover, in a world first, the project aims to assess c ....Understanding Australia by analysing wastewater during the Census 2021 . This project aims to utilise the Australian Census 2021, a unique opportunity to link exposure to chemical and biological hazards with catchment socio-demographic data via systematic wastewater analysis. The project is expected to advance our capabilities to identify emerging hazards and understand factors that affect spatiotemporal trends in hazards across Australia. Moreover, in a world first, the project aims to assess chemical fate on a national level by linking sales/use with fate and release from wastewater treatment plants and assess treatment efficiency at >100 plants around Australia. The project expects to provide insight for government, wastewater managers and industry into hazards that may affect environmental and human health.Read moreRead less
Parole in crisis? Public opinion on the use of parole. Serious crimes committed by parolees in Australia have brought parole into the public eye. Without concrete evidence, governments often act on the assumption that the public holds punitive attitudes. This project is expected to develop an evidence base to inform policy on parole at a crucial time when governments are under pressure to restrict its use. Three mixed-method studies aim to assess: what public views on parole are; why the public ....Parole in crisis? Public opinion on the use of parole. Serious crimes committed by parolees in Australia have brought parole into the public eye. Without concrete evidence, governments often act on the assumption that the public holds punitive attitudes. This project is expected to develop an evidence base to inform policy on parole at a crucial time when governments are under pressure to restrict its use. Three mixed-method studies aim to assess: what public views on parole are; why the public holds these views; and what influence these views have on policy and practice. The project is expected to make contributions to: creating information strategies that properly inform the public; supporting prisoner reintegration strategies; and shaping criminal justice policies based on informed community feedback.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100020
Funder
Australian Research Council
Funding Amount
$520,000.00
Summary
Collaborative high bio-containment immunological research facility. Emerging infectious diseases are a serious threat to animals and humans, with most new human infections originating in animals. Our capacity to study these infections and their effects on the immune system is limited. This Facility will provide core equipment for analysis of immune responses to infection at the highest levels of bio-containment.