Real-time imaging of the initiation of adaptive immunity in vivo. Understanding the first few hours of an immune response is fundamental to understanding how the human immune system functions. The immune system mounts our responses to infectious diseases, but can also cause autoimmune disease, allergy, and organ graft rejection. We will study how naive antigen-specific T cells first contact antigen in lymph nodes using 2-photon intravital microscopy. The research has the potential to change the ....Real-time imaging of the initiation of adaptive immunity in vivo. Understanding the first few hours of an immune response is fundamental to understanding how the human immune system functions. The immune system mounts our responses to infectious diseases, but can also cause autoimmune disease, allergy, and organ graft rejection. We will study how naive antigen-specific T cells first contact antigen in lymph nodes using 2-photon intravital microscopy. The research has the potential to change the way we think about the clonal selection of lymphocytes, the fundamental theory underlying our understanding of the immune system.Read moreRead less
Development of microbial bioproducts for the suppression of inflammation. Asthma and inflammatory diseases are serious health problems that result from excessive inflammation. Exposure to bacteria may reduce inflammation. This project will identify the bacterial components that reduce inflammation and develop them into new anti-inflammatory therapies for asthma.
Non-equilibrium reacting shock layers. This project aims is to study the non-equilibrium aerodynamic processes involved in hypervelocity flight. The design of vehicles for high speed flight is critically dependent on modelling the interactions between the flow field and the airframe, and the current lack of understanding is restricting the scope and benefit of viable activities in space. The expected outcomes include the ability to design optimised heat shields and air-frames with minimum mass a ....Non-equilibrium reacting shock layers. This project aims is to study the non-equilibrium aerodynamic processes involved in hypervelocity flight. The design of vehicles for high speed flight is critically dependent on modelling the interactions between the flow field and the airframe, and the current lack of understanding is restricting the scope and benefit of viable activities in space. The expected outcomes include the ability to design optimised heat shields and air-frames with minimum mass and maximum payload, precisely targeting specific flight conditions and vehicle shapes. The prospective benefits include increased productivity and reliability and reduced cost of missions to and from space, and a proliferation of new applications which this understanding will facilitate.Read moreRead less
CD4 T cell programming by neonatal and early-life infection. T lymphocytes (T cells) are white blood cells that play a critical role in protecting the body from infection. Before T cells can function they need to be programmed so that they can specifically respond to an infectious agent (a type of bacteria or virus). Inappropriate programming can lead to disease. Whether T cells respond to an infectious agent or foreign substance in a protective or destructive manner may critically depend on the ....CD4 T cell programming by neonatal and early-life infection. T lymphocytes (T cells) are white blood cells that play a critical role in protecting the body from infection. Before T cells can function they need to be programmed so that they can specifically respond to an infectious agent (a type of bacteria or virus). Inappropriate programming can lead to disease. Whether T cells respond to an infectious agent or foreign substance in a protective or destructive manner may critically depend on the age that an individual first encounters the infection. Our project will identify critical periods in life that direct T cell programming to subsequent protective or destructive responses, providing new insights into the developing immune system that may be exploited to treat disease or develop vaccines.Read moreRead less
Ablative thermal protection systems. The project will study ablative reentry heat shields by experiments simulating hypervelocity atmospheric flight. The results will enable the design of the advanced spacecraft which are needed to extend mans exploration of the universe. Data will be validated by comparison with flights such as the Japanese Hayabusa asteroid sample return mission.
Analysing the protective role of platelets during malaria infection. Platelets protect the host during malarial infection. This project aims to study how platelets kill the malaria parasite by investigating the role of host molecules and their potential as novel antimalarial agents. The role of platelets in the pathogenesis of cerebral malaria syndrome will also be investigated.
Designing Radiation-Tolerant Reconfigurable Systems for Space. The processing speed, cost and flexibility requirements of future satellite-based applications cannot be satisfied with conventional radiation-hardened processors or custom integrated circuits. This project aims to develop key technology to enable off-the-shelf hardware to be customised for this use without compromising reliability. The project aims to develop the design methods needed to implement a given set of satellite applicatio ....Designing Radiation-Tolerant Reconfigurable Systems for Space. The processing speed, cost and flexibility requirements of future satellite-based applications cannot be satisfied with conventional radiation-hardened processors or custom integrated circuits. This project aims to develop key technology to enable off-the-shelf hardware to be customised for this use without compromising reliability. The project aims to develop the design methods needed to implement a given set of satellite applications on a processing platform composed of application-specific soft processors and accelerator circuits hosted on conventional reconfigurable logic devices. Crucially, the solution architecture is expected to be sufficiently hardened against radiation-induced errors while meeting performance and circuit area constraints.Read moreRead less
Understanding the dynamics of T cell responses to chronic infection. The health, social, and economic impact of chronic infections on the Australian and global populations is enormous. A major obstacle to the development of vaccines against chronic infections is that we have a poor understanding of immune responses to persistent infections. We aim to use bioinformatics and mathematical modelling to understand immune responses to persistent viruses so that we can improve the long-term immune cont ....Understanding the dynamics of T cell responses to chronic infection. The health, social, and economic impact of chronic infections on the Australian and global populations is enormous. A major obstacle to the development of vaccines against chronic infections is that we have a poor understanding of immune responses to persistent infections. We aim to use bioinformatics and mathematical modelling to understand immune responses to persistent viruses so that we can improve the long-term immune control of chronic viral infections such as the human immunodeficiency virus (HIV). This project will strengthen Australian research in the area of interdisciplinary approaches to immunology, which is becoming crucial to interpreting the rapidly increasing volume of data obtained using advanced experimental techniques.Read moreRead less
Understanding the T cell repertoire in health and disease. Immune recognition of viruses usually involves a large number of different 'killer T cells' that kill cells infected by virus. However, during prolonged infection or in the elderly the number of different killer T cells that recognise the virus is greatly reduced. This reduction in the diversity of the immune response allows the virus to avoid immune recognition, and leads to more severe infection. We aim to understand how diversity is ....Understanding the T cell repertoire in health and disease. Immune recognition of viruses usually involves a large number of different 'killer T cells' that kill cells infected by virus. However, during prolonged infection or in the elderly the number of different killer T cells that recognise the virus is greatly reduced. This reduction in the diversity of the immune response allows the virus to avoid immune recognition, and leads to more severe infection. We aim to understand how diversity is generated in the immune response, and how it becomes narrowed with age or prolonged infection. This information can be used to design vaccines for persistent infections such as HIV, and to improve immune control of infection in the elderly.Read moreRead less
Statistical Methods for Flow Cytometric Data. The project will aid users of flow cytometry throughout Australia. It will help foster collaborations between the biological and mathematical scientists. Biological research is an important part of Australia's future and is becoming very quantitative. During the course of the project, two PhD students will be provided strong training in Statistics geared towards biological applications. The project is aligned with the 8th Human Leucocyte Differentiat ....Statistical Methods for Flow Cytometric Data. The project will aid users of flow cytometry throughout Australia. It will help foster collaborations between the biological and mathematical scientists. Biological research is an important part of Australia's future and is becoming very quantitative. During the course of the project, two PhD students will be provided strong training in Statistics geared towards biological applications. The project is aligned with the 8th Human Leucocyte Differentiation Antigen workshop to culminate in Adelaide in December 2004 and will aid the fight against blood cell cancers. The project will also aid research on plankton with potential commercial benefits for Australia's marine scallop industry.
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