Fine Mapping Of The ADH Region For Alcohol Metabolism, Use And Dependence
Funder
National Health and Medical Research Council
Funding Amount
$215,690.00
Summary
It is widely known that alcohol use and alcohol dependence can cause many social problems and morbidity. We know that social and and cultural factors can affect the possibility of becoming alcohol dependent. We also know that inheritance plays a major role in the risk of becoming dependent upon alcohol. Two inherited causes or genes have already been identified as causing some people to avoid alcohol and so have less chance of becoming dependent upon it. Clues as to why this happens come from wh ....It is widely known that alcohol use and alcohol dependence can cause many social problems and morbidity. We know that social and and cultural factors can affect the possibility of becoming alcohol dependent. We also know that inheritance plays a major role in the risk of becoming dependent upon alcohol. Two inherited causes or genes have already been identified as causing some people to avoid alcohol and so have less chance of becoming dependent upon it. Clues as to why this happens come from what happens to alcohol following a drink. The body detoxifies itself of alcohol in the liver. There it is converted to very highly toxic acetaldehyde and this is normally rapidly removed by a protein called aldehyde dehydrogenase. Some people do not have a normally functioning form of this protein and cannot remove the acetaldehyde from their bodies. They suffer unpleasant side effects such as nausea, facial flushing and sickness. Consequently they learn by experience to avoid alcohol use and are less likely to develop dependence. We now know that even people with a normally inherited form of aldehyde dehydrogenase can have a lowered risk of dependence. The rate at which our livers convert alcohol to actetaldehyde is also a key factor. Those who are inherently quick at this process again learn to avoid alcohol, others are more at risk. The hypothesis will be tested with a unique set of twins who have provided us with detailed information on how quickly they detoxify alcohol and of their drinking habits for over 20 years. Collectively they will enable us to determine if there is a major genetic influence on alcohol use and dependence that is caused by inter-individual differences in a gene for alcohol metabolism. The DNA of these twins will be used to locate mutations that we predict have a common effect upon our measures of alcohol detoxification, drinking habits and risk of alcoholism.Read moreRead less
Drinking Patterns, Gender And Social Roles In Alcohol Problems In Victoria, In An International Comparative Context
Funder
National Health and Medical Research Council
Funding Amount
$342,239.00
Summary
The varied impacts of drinking in the family and other gendered relations are an important and understudied aspect of alcohol studies, with general social and policy implications. The proposed research will make an important contribution to developing quantitative research in this area in Australia. The project uses concepts and measures which are novel in an Australian environment, and the international comparative aspect of the project, with comparable questionnaires in a wide diversity of soc ....The varied impacts of drinking in the family and other gendered relations are an important and understudied aspect of alcohol studies, with general social and policy implications. The proposed research will make an important contribution to developing quantitative research in this area in Australia. The project uses concepts and measures which are novel in an Australian environment, and the international comparative aspect of the project, with comparable questionnaires in a wide diversity of societies, is novel and innovative for the alcohol research field in general. Measures of social problems from drinking, and particularly and family and relationship, developed in analysing the study material will be made more broadly available for use in future studies, raising the possibility that the study may serve as a first measurement point for future data-series over time.Read moreRead less
Alcohol Consumption And Health Inequalities - The Role Of Alcohol Policy
Funder
National Health and Medical Research Council
Funding Amount
$299,564.00
Summary
This fellowship will fund a program of work examining the contribution of alcohol consumption and related harm to socioeconomic inequalities in Australian's health. A particular focus will be on the role of alcohol policy in perpetuating or reduction health inequalities. The fellowship will involve the collection of new and important data and the use of innovative analytical approaches to explore these issues.
Reducing Alcohol-related Harm In Rural Communities
Funder
National Health and Medical Research Council
Funding Amount
$265,000.00
Summary
In 1992 in Australia, there were an estimated 3,660 alcohol-related deaths and 71,593 alcohol-related hospital episodes, resulting in a total economic cost of $4,031.9 million, 84% of which was avoidable. In 1998, about half of all males and a third of all females drank at least once a month at levels that placed them at risk of harm. In NSW, alcohol was estimated as being a causal factor in about one-quarter of all road traffic deaths in 1995 and was associated with a 58% increase in hospital u ....In 1992 in Australia, there were an estimated 3,660 alcohol-related deaths and 71,593 alcohol-related hospital episodes, resulting in a total economic cost of $4,031.9 million, 84% of which was avoidable. In 1998, about half of all males and a third of all females drank at least once a month at levels that placed them at risk of harm. In NSW, alcohol was estimated as being a causal factor in about one-quarter of all road traffic deaths in 1995 and was associated with a 58% increase in hospital utilistion rates between 1988-89 and 1990-91. The burden of suffering appears disproportionately higher in rural areas of NSW: per capita rate of convictions associated with a prescribed alcohol concentration in rural towns was approximately double that in metropolitan areas in 2000. The rate of attendances at hospital accident and emergency departments was also higher in rural areas. These data suggest a need for additional effort to reduce alcohol-related harm in rural, relative to metropolitan, areas. In Australia, there have been no well-controlled, community-based, attempts to reduce alcohol-related harm by simultaneously implementing a range of interventions. The conduct of a large-scale randomised controlled trial (RCT) to investigate the effectiveness of this approach is difficult to justify, due to the substantial costs associated with such a rigorous design. However, a less rigorus, though equally valid, design, such as a stepped wedged approach, would likely provide good evidence to justify the subsequent conduct of an RCT. If the expected outcomes are not achieved, the conduct of an RCT can be postponed until reasonable preliminary evidence regarding the types of community-based interventions most likely to be effective is obtained. In either case, this study will provide valuable information as to which community-based interventions, and in what combination, are most likely to reduce the occurrence of alcohol-related harm in rural communities in Australia.Read moreRead less
Driving Under The Influence Of Psychoactive Prescription Benzodiazepines And Alcohol
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
Driving enables people to travel to work and social events, and is thus an important determinant of quality of life. Driving is also a potentially dangerous activity, as there is a risk of becoming involved in accidents. In fact, car accidents are one of the leading causes of injury and death. Whilst alcohol remains the most prevalent drug causing impairment of driving performance, other drugs, especially in combination with alcohol, are thought to increase collision risk.