The Australian Research Data Commons (ARDC) invites you to participate in a short survey about your
interaction with the ARDC and use of our national research infrastructure and services. The survey will take
approximately 5 minutes and is anonymous. It’s open to anyone who uses our digital research infrastructure
services including Reasearch Link Australia.
We will use the information you provide to improve the national research infrastructure and services we
deliver and to report on user satisfaction to the Australian Government’s National Collaborative Research
Infrastructure Strategy (NCRIS) program.
Please take a few minutes to provide your input. The survey closes COB Friday 29 May 2026.
Complete the 5 min survey now by clicking on the link below.
The Role Of Fc RIIa In Antibody Dependent Tissue Destruction In Autoimmunity
Funder
National Health and Medical Research Council
Funding Amount
$538,206.00
Summary
These studies will attempt to identify the cause autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus we are using a unique strain of mice carrying a unique human protein called Fc receptor that triggers inflammatory cells. We will identify the processes that start inflammation, and those that continue throughout chronic autoimmune disease. These studies will be applied to the development of new treatments for autoimmune disease.
Inflammasome Function In Gastrointestinal Immunity And Inflammation
Funder
National Health and Medical Research Council
Funding Amount
$421,116.00
Summary
The immune system in the gut provides a vital defence against microbes. If these defences are ineffective we become infected leading to gastroenteritis, a major cause of death in the third world and hospitalisation in developed countries. Conversely, excessive or inappropriate activation of these defences can cause inflammatory disease. This project will investigate microbial detection in the gut, and aims to discover new, more effective ways to treat gastrointestinal infection and inflammation.
Studies On The Role Of The MIP-3beta/SLC System In The Priming Phase Of The Cytotoxic T Lymphocyte Response.
Funder
National Health and Medical Research Council
Funding Amount
$425,250.00
Summary
Generation of cytotoxic T cells (CTLs) is important for defence against viruses and cancer cells. However, when activated inappropriately, CTLs can contribute to diseases such as diabetes as well as transplant rejection. We intend to study the role of several recently-discovered proteins in this process. The outcome of this work may lead to the development of molecules that control CTL generation more specifically than existing therapeutics. Such inhibitors would potentially be useful in the tre ....Generation of cytotoxic T cells (CTLs) is important for defence against viruses and cancer cells. However, when activated inappropriately, CTLs can contribute to diseases such as diabetes as well as transplant rejection. We intend to study the role of several recently-discovered proteins in this process. The outcome of this work may lead to the development of molecules that control CTL generation more specifically than existing therapeutics. Such inhibitors would potentially be useful in the treatment of a range of human diseases.Read moreRead less
NOD-like Receptors And Severe Malaria: Do Inflammasomes Mediate Immunopathogenesis?
Funder
National Health and Medical Research Council
Funding Amount
$263,001.00
Summary
Our immune system is very effective in preventing disease. But sometimes our immune cells overreact and actually make us sick. Recently, a new component of the immune system, the inflammasome, was discovered. Overreaction of the inflammasome can result in fever, inflammation, and even death. This project will investigate whether inflammasome overreaction exacerbates diseases as diverse as malaria and cancer, and whether drugs that inhibit the inflammasome can help cure these and other diseases.
Immunological Therapies For Cancer, Chronic Infection And Autoimmunity
Funder
National Health and Medical Research Council
Funding Amount
$10,891,788.00
Summary
The team comprises five leading scientists with a history of successful investigation into the role of the immune system in cancers, chronic viral infections, and autoimmune diseases. There is a large unmet need for effective solutions with fewer side effects in these diseases which cause a high disease burden in our society. In this program, we particularly seek to develop novel vaccines for chronic infections and autoimmune diseases, and to improve the safety of bone marrow transplantation.
Understanding The Role Of Chemokine Receptor Modulation In T Cell Trafficking
Funder
National Health and Medical Research Council
Funding Amount
$391,650.00
Summary
This research will begin to determine the significance of changes in the amount of recently-discovered proteins on the surface of cells called T lymphocytes. These cells control immune responses and move throughout the body to do this. Sometimes, they are activated inappropriately and cause diseases like asthma, arthritis and multiple sclerosis. It is therfore important to understand how the movement of these cells through the body is controlled. A better understanding of this process shuld allo ....This research will begin to determine the significance of changes in the amount of recently-discovered proteins on the surface of cells called T lymphocytes. These cells control immune responses and move throughout the body to do this. Sometimes, they are activated inappropriately and cause diseases like asthma, arthritis and multiple sclerosis. It is therfore important to understand how the movement of these cells through the body is controlled. A better understanding of this process shuld allow us to design better ways to control it, thereby controlling the negative aspects of T cell activation.Read moreRead less
How IL-4 Suppresses TNF And IL-1 Production By Activated Human Monocytes And Macrophages
Funder
National Health and Medical Research Council
Funding Amount
$432,750.00
Summary
Chronic inflammatory diseases are an enormous and growing health problem. There is a continuing search for improved and more targeted treatments. We have been studying a cytokine called interleukin-4 which can suppress the production by blood cells of many of the inflammatory mediators that initiate and maintain inflammation. With the recognition that interleukin-4 has this anti-inflammatory activity on blood cells, there was considerable optimism that this molecule may not only be a natural reg ....Chronic inflammatory diseases are an enormous and growing health problem. There is a continuing search for improved and more targeted treatments. We have been studying a cytokine called interleukin-4 which can suppress the production by blood cells of many of the inflammatory mediators that initiate and maintain inflammation. With the recognition that interleukin-4 has this anti-inflammatory activity on blood cells, there was considerable optimism that this molecule may not only be a natural regulator of inflammation but also used in immunotherapy. However we do not know how this molecule downregulates inflammatory blood cells. It will be necessary to know this if it is to be used in human gene therapy for treatment of inflammatory diseases. Cells must be activated before a molecule which is anti-inflammatory can be effective. Different cell types from different inflammatory sites will be studied to better characterise different activation pathways. How interleukin-4 regulates these pathways will be studied. Once identified, treatments based on the properties of interleukin-4 may be designed-optimised.Read moreRead less
Chemokine Mediated Collaboration Between T Cells And Dendritic Cells During Inflammation
Funder
National Health and Medical Research Council
Funding Amount
$342,384.00
Summary
The immune system protects us from foreign pathogens by using multiple immune cell types. Immune cells need to migrate and interact with each other in order to function properly. When immune cells fail to migrate appropriately, autoimmune diseases or immunodeficiency may develop. By understanding the molecules regulating their migration, we can promote or inhibit immune cell function.
Characterisation Of The Anti-inflammatory Properties Of The N-3 Fatty Acid Product, 4-hydroxy-hexenal.
Funder
National Health and Medical Research Council
Funding Amount
$524,559.00
Summary
A concerted effort is being made by experts in the field of omega 3 fats (fish oils) to make specific recommendation on their use to improve human health . We have reasoned that the characterisation of a major oxidation product of these oils could be a key to understanding how these fats benefit us. The project is likely to influence the formulation of fish oils to enhance their health promoting properties.