Increased Airway Smooth Muscle Mass As An Independent Determinant Of Asthma Pathogenesis And Severity
Funder
National Health and Medical Research Council
Funding Amount
$409,966.00
Summary
Asthma is a major health burden to the community. The most common form of the disease is allergic asthma and it is thought that allergic inflammation drives associated airway abnormalities including increased airway smooth muscle (ASM) mass. This study tests a new hypothesis that airway abnormalities and allergy have separate origins but combine to produce allergic asthma, and it’s the individuals with the greatest amount of ASM who develop clinically severe asthma.
Investigating The Effects Of Macrolides On Excessive Synthesis And Secretion Of Airway Mucins Using Novel Ex Vivo And In Vivo Approaches
Funder
National Health and Medical Research Council
Funding Amount
$520,821.00
Summary
Many people have difficulty breathing because the airway tubes that move air in and out of their lungs are blocked by excessive amounts of sticky mucus. Our project will use new techniques developed in our laboratories to investigate whether a group of medicines called “macrolides” can prevent the excessive production and release of mucus in the airways, and thus be beneficial in treating asthma, and potentially other lung diseases.
Expectations and commitments in the Australia-USA alliance. This project aims to investigate the gap between the high expectations of mutual support and the lack of detailed security commitments in the Australia-US Alliance. The project intends to use a focused approach that captures thematic aspects of the alliance through project frames and historical slices across time. Expected outcomes can advance understanding of how alliances operate as security institutions. The outcomes can help to prom ....Expectations and commitments in the Australia-USA alliance. This project aims to investigate the gap between the high expectations of mutual support and the lack of detailed security commitments in the Australia-US Alliance. The project intends to use a focused approach that captures thematic aspects of the alliance through project frames and historical slices across time. Expected outcomes can advance understanding of how alliances operate as security institutions. The outcomes can help to promote a more informed national conversation about the costs and benefits of Australia's security relationship with the United States of America (USA) and contribute to debates over the future of the Australia-USA Alliance during a period of strategic uncertainty.Read moreRead less
Epithelial Drivers Of Neutrophil Plasticity In Early Cystic Fibrosis Lung Disease
Funder
National Health and Medical Research Council
Funding Amount
$849,462.00
Summary
Why airway inflammation becomes chronic so early in life for people with cystic fibrosis (CF) is unclear. This project will use the latest techniques to characterise immune cells found in airways of infants with CF and model in the laboratory how immune cells react to the CF airway. We will challenge CF airway cells with different bugs that can infect the lung, then see if the responses by CF airway cells can change the normal response of immune cells, triggering chronic disease.
The Identification Of Thoracic Targets For Prevention And Intervention In Bronchopulmonary Dysplasia
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
The persistence of breathing problems from infancy to later life is a complication of premature birth with lifelong consequences. Breathing problems often occur together with lung disease, but prematurity can also affect heart and blood vessel development, and weakness of the main breathing muscle. We will find out how much the heart, lungs and diaphragm contribute to breathing problems in babies; helping us to better predict, diagnose and treat severe breathing problems in babies born preterm.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100133
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
National Facility for Physical Blast Simulation (NFPBS). Recent terrorist attacks employing large quantities of high explosives have prompted the international demand for experimental investigation of civil infrastructure response to shock wave loadings. The National Facility for Physical Blast Simulation (NFPBS) is one of only a few in the world that are suitable for conducting experimental research via a physically generated blast approach.
Passive Positioning and Tracking of Flying Objects Using Satellite Signals. Along with the deployment of low Earth orbit satellite constellations for global satellite Internet services, such as Starlink, Ku/Ka/V band microwave signals from space will be available anywhere on Earth 24/7. Utilising the microwave signals, this project aims to investigate a high-resolution cost-effective solution to position and track un-cooperative flying objects, and expects to generate new knowledge in the area o ....Passive Positioning and Tracking of Flying Objects Using Satellite Signals. Along with the deployment of low Earth orbit satellite constellations for global satellite Internet services, such as Starlink, Ku/Ka/V band microwave signals from space will be available anywhere on Earth 24/7. Utilising the microwave signals, this project aims to investigate a high-resolution cost-effective solution to position and track un-cooperative flying objects, and expects to generate new knowledge in the area of remote sensing and to make Australia the leader in passive flying objects positioning and tracking. This should provide significant benefits, such as enabling new applications for future drone delivery systems or aerial taxi services, and benefiting the air transport industry, the defence industry, and bird conservation.Read moreRead less
Animal camouflage patterns. This project aims to understand whether animal camouflage patterns can produce the illusion of 3D form. By using the latest techniques in 3D computer imaging, vision science and animal behaviour, this work addresses the previously untested but fundamental theory on 3D camouflage patterns. The development of theory on the ecology and evolution of animal patterning will enhance our understanding of the processes that maintain biological diversity. This research is expec ....Animal camouflage patterns. This project aims to understand whether animal camouflage patterns can produce the illusion of 3D form. By using the latest techniques in 3D computer imaging, vision science and animal behaviour, this work addresses the previously untested but fundamental theory on 3D camouflage patterns. The development of theory on the ecology and evolution of animal patterning will enhance our understanding of the processes that maintain biological diversity. This research is expected to have broad impact across multiple disciplines and will inform novel military defence strategies and contribute to emerging bio-inspired technologies.Read moreRead less
Space-based space surveillance with robust computer vision algorithms. Space-based space surveillance with robust computer vision algorithms. This project aims to develop computer vision algorithms to detect man-made objects in space. These algorithms function on nanosatellite platforms, enabling space-based space surveillance. This technology is expected to provide always-on monitoring of the Earth's orbit to enhance existing defence infrastructure and protect vital space assets, including comm ....Space-based space surveillance with robust computer vision algorithms. Space-based space surveillance with robust computer vision algorithms. This project aims to develop computer vision algorithms to detect man-made objects in space. These algorithms function on nanosatellite platforms, enabling space-based space surveillance. This technology is expected to provide always-on monitoring of the Earth's orbit to enhance existing defence infrastructure and protect vital space assets, including communications and navigational satellites, in Earth’s orbit from collisions and covert sabotage. Increased space use by government and civilian agencies opens up opportunities for the space industry. This project is expected to develop Australia’s space surveillance capabilities, protect space assets and capture a growing market.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100106
Funder
Australian Research Council
Funding Amount
$780,000.00
Summary
A global fireball observatory. This project aims to expand the Desert Fireball Network (DFN) and build a Global Fireball Observatory. Nearly everything known about the origin and evolution of the solar system comes from analysis of meteorite falls, but scientists have almost no constraint on where they come from. This project will address this constraint by tracking hundreds of meteorite falls, and pinpointing each one’s origin in the solar system. Benefits include capitalising on the innovation ....A global fireball observatory. This project aims to expand the Desert Fireball Network (DFN) and build a Global Fireball Observatory. Nearly everything known about the origin and evolution of the solar system comes from analysis of meteorite falls, but scientists have almost no constraint on where they come from. This project will address this constraint by tracking hundreds of meteorite falls, and pinpointing each one’s origin in the solar system. Benefits include capitalising on the innovations and technologies that underpinned the DFN, and leveraging a NASA partnership for administrative support and advanced instrumentation development. Tracking for space situational awareness is also expected to benefit Australian national security.Read moreRead less