Ventilation Heterogeneity And Airway Remodelling In Asthma
Funder
National Health and Medical Research Council
Funding Amount
$522,586.00
Summary
Asthma is a common and important as a cause of significant symptoms and even death. Associated with asthma is narrowing and stiffening of the arways which causes uneven ventilation of the lungs and reduced lung function. We have developed a new technique of imaging the lungs, as well as new lung function tests which measure uneven ventilation and stiffening of airways. This will help us design better medications, and help predict those who are at risk or severe asthma and death.
Identifying The Microbiological Risk Factors For Acute Lower Respiratory Infection In Indigenous Children To Inform Future Intervention Strategies
Funder
National Health and Medical Research Council
Funding Amount
$495,745.00
Summary
Lung infections such as pneumonia are common in Indigenous children, and can lead to repeated hospitalisation and permanent lung damage. They are also an important cause of preventable death in children. This study will look at the role of bacteria and viruses in lung infections, and will inform interventions to reduce the burden and consequences of lung infections in Indigenous children.
Electro-Optical Primers for Safe Use and Clean Manufacturing. Conventional primers contain a mechanically-sensitive primary explosive that is used to detonate the more stable propellant in a bullet. This project aims to address the health and environmental impacts of heavy metals in current primers by replacing them with benign, electrically or optically activated silicon-based materials. Modern semiconductor fabrication techniques will be used to develop safe and clean primers through cost-effe ....Electro-Optical Primers for Safe Use and Clean Manufacturing. Conventional primers contain a mechanically-sensitive primary explosive that is used to detonate the more stable propellant in a bullet. This project aims to address the health and environmental impacts of heavy metals in current primers by replacing them with benign, electrically or optically activated silicon-based materials. Modern semiconductor fabrication techniques will be used to develop safe and clean primers through cost-effective doping and deposition protocols. The expected outcomes of the project include a sovereign primer manufacturing capability for Australia. This will provide a significant strategic advantage and health benefits for law enforcement and defence personnel during live fire training and firing range exercises.Read moreRead less
Civilian Protection and the Use of Force in UN Peacekeeping Operations. This project seeks to evaluate the use of force to protect civilians in United Nations peacekeeping. United Nations peacekeepers are on the frontline of efforts to protect civilians from violence. More than 100 were killed in 2014. Hundreds of thousands of civilians depend on peacekeepers for their safety. To date, however, there has been little systematic evaluation of the impact of the use of force for civilian protection ....Civilian Protection and the Use of Force in UN Peacekeeping Operations. This project seeks to evaluate the use of force to protect civilians in United Nations peacekeeping. United Nations peacekeepers are on the frontline of efforts to protect civilians from violence. More than 100 were killed in 2014. Hundreds of thousands of civilians depend on peacekeepers for their safety. To date, however, there has been little systematic evaluation of the impact of the use of force for civilian protection mandates on both immediate protection goals and the wider goals of peacekeeping. This project aims to assess the impact of the implementation of mandates to use force to protect civilians. Through a focused comparison of six missions, it plans to identify what works, what doesn't, and the factors which determine these outcomes in order to identify ways of improving performance in the future.Read moreRead less
Revolutionising The Diagnosis And Monitoring Of CF Lung Disease
Funder
National Health and Medical Research Council
Funding Amount
$818,391.00
Summary
Cystic fibrosis (CF) lung disease starts early in childhood and relentlessly progresses, with early death a common outcome. There is currently no method capable of detecting very early disease onset nor directly assessing the effectiveness of putative treatments. This project will apply our globally unique X-ray imaging tools, which are capable of imaging lung function at any point across the entire lung, for the very early detection of CF and assessment of clinically applicable treatments.
Sensing and Communications for Tactical Radio: Mapping the RF Weather. This project investigates sensing, localisation and communication strategies to improve the performance of modern tactical radio networks. Such networks face all of the well-known design challenges of mobile ad-hoc networks (MANETs) but with added complication of a contested and adversarial operating environment. By exploiting the power of radio nodes to sense the radio spectrum, as well as to communicate over it, a distribut ....Sensing and Communications for Tactical Radio: Mapping the RF Weather. This project investigates sensing, localisation and communication strategies to improve the performance of modern tactical radio networks. Such networks face all of the well-known design challenges of mobile ad-hoc networks (MANETs) but with added complication of a contested and adversarial operating environment. By exploiting the power of radio nodes to sense the radio spectrum, as well as to communicate over it, a distributed network of nodes can create a detailed picture of the surrounding radio-frequency (RF) environment: the nodes can work together to map the “RF weather”. In this project we will design advanced sensing and localisation methods to accurately map the RF spectrum, and then exploit this map in communication system design.Read moreRead less
Optimising Non-invasive Ventilation At Birth For Preterm Infants
Funder
National Health and Medical Research Council
Funding Amount
$735,912.00
Summary
Infants born very premature require respiratory support at birth to make the transition to newborn life. As these infants are very immature and prone to injury, modern respiratory care strategies utilise the least invasive approaches mainly applied using a facemask. However, we have discovered that the larynx is closed at birth and thereby prevents air from entering the lung. This application is focussed on optimising the efficiency of facemask ventilation at birth and stimulating breathing.
Obstructive Sleep Apnoea Phenotypes And Treatment In Quadriplegia
Funder
National Health and Medical Research Council
Funding Amount
$599,635.00
Summary
Losing function in your arms and legs after an injury (quadriplegia) is a catastrophic event. Quadriplegia also results in obstructive sleep apnoea; a condition where the throat closes repeatedly while asleep causing sleepiness, poor concentration and cardiovascular diseases like stroke. Despite most people with quadriplegia having this disease, the cause is unknown. This project will thoroughly investigate obstructive sleep apnoea causes in people with quadriplegia and test a possible treatment
Discovery Early Career Researcher Award - Grant ID: DE220101094
Funder
Australian Research Council
Funding Amount
$431,900.00
Summary
Energy absorption and impact mechanics of origami structures and materials. This project aims to understand the dynamic behaviour of origami structures and metamaterials by utilising interdisciplinary approaches. This project expects to generate new knowledge in the areas of origami engineering and structural mechanics. The success of this project will form a foundation for studying energy absorption and impact mechanics of origami family; the fundamental physics and mechanics will be applied to ....Energy absorption and impact mechanics of origami structures and materials. This project aims to understand the dynamic behaviour of origami structures and metamaterials by utilising interdisciplinary approaches. This project expects to generate new knowledge in the areas of origami engineering and structural mechanics. The success of this project will form a foundation for studying energy absorption and impact mechanics of origami family; the fundamental physics and mechanics will be applied to characterise microstructures and design novel metamaterials and offer a way of exploring new materials with superior and tuneable performance. This should provide significant benefits to improvement of their safety, stability and reliability performance in applications such as vehicles, warships and offshore engineering.Read moreRead less
Origami structures and materials: energy absorption and impact mechanics. This project will devise novel structures and advanced metamaterials to mitigate injury and death from impact or blast loading, using traditional origami folding concepts of design. This technology will have applications to many industries and occupations including vehicle manufacture and the military, as well as personal and public safety. Experiments and advanced numerical simulations will be performed and then analytica ....Origami structures and materials: energy absorption and impact mechanics. This project will devise novel structures and advanced metamaterials to mitigate injury and death from impact or blast loading, using traditional origami folding concepts of design. This technology will have applications to many industries and occupations including vehicle manufacture and the military, as well as personal and public safety. Experiments and advanced numerical simulations will be performed and then analytical models of structural plasticity and impact dynamics will be established to capture the physics involved. The findings will provide an insight into the fundamental mechanics of structures and metamaterials, as well as guidelines for their optimum design.Read moreRead less