Pathogenesis And Therapeutic Modulation Of Aggressive Behaviour In A Mouse Model Of Autism Spectrum Disorder
Funder
National Health and Medical Research Council
Funding Amount
$583,015.00
Summary
This project focuses on understanding the causes of aggressive behaviour in mice that have a human gene mutation found in autism. Aggressive behaviour is common in autism patients and can have severe consequences on education and employment opportunities. These mice also show excess dampening of brain function (inhibition). This project will test if aggression in these mice is caused by altered inhibition.
The Effect Of Foot Massage On Agitation In People Living With Dementia In Residential Care Settings: An RCT
Funder
National Health and Medical Research Council
Funding Amount
$286,301.00
Summary
This study investigates the effect of a 10-minute foot massage on agitated behaviours of older people living with dementia in residential care settings. The study builds on previous complementary research and provides further evidence to help assess whether foot massage is, indeed, a low cost, low risk, non-pharmacological and easily applied procedure that produces tangible positive psychological and physiological effects.
Computer-assisted Clinical Guidelines For The Management Of Manifestations Of Anxiety, Aggression And Depression
Funder
National Health and Medical Research Council
Funding Amount
$354,032.00
Summary
This project focuses on creating a new approach to integration of clinical guidelines and the development of a computer-assisted tool to support medical reasoning in psychogeriatrics. The primary focus of this research is on helping medical practitioners to better manage dementia patients with symptoms of anxiety, aggression and depression living in nursing homes. It has the potential to fundamentally improve the way guidelines are utilised in clinical practice
Alcohol, Angry Rumination, And Aggression: The Role Of Acute Impairment Of Executive Functioning
Funder
National Health and Medical Research Council
Funding Amount
$341,780.00
Summary
In Australia, alcohol-induced aggression imposes substantial psychological, public health, social, and economic burdens on victims, perpetrators, and society. When people drink and brood over interpersonal transgresssions, they are at increased risk of violence, even toward the innocent. The goal of the proposed research is to identify neuropsychological mechanisms that account for this increased aggression.
Improving Health Outcomes In Drug Overdose And Envenoming: Risk Assessment And Interventional Studies
Funder
National Health and Medical Research Council
Funding Amount
$772,209.00
Summary
The research aims to improve our understanding of the mechanisms and treatments for poisoning and envenoming. Observational studies measuring toxin levels will be done to investigate the effects of drug overdose and terrestrial and marine envenoming. Clinical trials will be done to investigate the benefit and safety of antivenom in snake/spider envenoming, antidotes and other treatments for drug overdose, including decontamination such as activated charcoal. Clinical studies will involve multipl ....The research aims to improve our understanding of the mechanisms and treatments for poisoning and envenoming. Observational studies measuring toxin levels will be done to investigate the effects of drug overdose and terrestrial and marine envenoming. Clinical trials will be done to investigate the benefit and safety of antivenom in snake/spider envenoming, antidotes and other treatments for drug overdose, including decontamination such as activated charcoal. Clinical studies will involve multiple hospitals across Australia.Read moreRead less
Does Omega-3 Supplementation Attenuate Aggressive Behaviour: A Multi-Centre Randomised Controlled Trial Of A Broadly Disseminable Strategy
Funder
National Health and Medical Research Council
Funding Amount
$845,278.00
Summary
Aggressive behaviour is a major problem worldwide, sometimes with dire consequences. Although there are many contributing factors, in this study we will test whether supplementing the diet with omega-3s will result in reduced aggressive behaviour in Australian prisoners. We will discuss the outcomes with key stakeholders, write a report to Corrective Services Administrators Council, develop education about omega-3s for inmates, and form a group to oversee these translation activities.
Microtubule Cytoskeleton In Tumourigenesis And Metastasis
Funder
National Health and Medical Research Council
Funding Amount
$612,885.00
Summary
Over one million cases of lung cancer are diagnosed each year worldwide, making this the leading cause of cancer death. Advanced non-small cell lung cancer (NSCLC) accounts for more than 80% of lung cancer cases. We have identified a protein called ?III-tubulin that is often highly expressed in aggressive and drug resistant NSCLC, and is involved in tumour formation. We will examine how ?III-tubulin is working and identify ways to target this protein to stop tumour growth.
The Effectiveness Of A Responsible Hospitality Audit And Feedback Intervention To Reduce Alcohol Related Harm
Funder
National Health and Medical Research Council
Funding Amount
$466,875.00
Summary
Alcohol is a major cause of death, injury and illness in Australia accounting for over 3,000 deaths and over 72,000 hospital admissions each year. Excessive drinking is estimated to cost the Australian community $7,560 million each year, representing 22% of all drug-related harm. Alcohol is a significant contributor to the occurrence of violence and crime. It is estimated that up to 70% of incidents attended by the police, and 77% of street offences such as assaults and malicious damage to prope ....Alcohol is a major cause of death, injury and illness in Australia accounting for over 3,000 deaths and over 72,000 hospital admissions each year. Excessive drinking is estimated to cost the Australian community $7,560 million each year, representing 22% of all drug-related harm. Alcohol is a significant contributor to the occurrence of violence and crime. It is estimated that up to 70% of incidents attended by the police, and 77% of street offences such as assaults and malicious damage to property, are alcohol-related. It is also estimated that 70% to 80% of night-time single-vehicle accidents are alcohol-related. A large proportion of assaults, offensive behaviour, malicious damage to property and drink driving occur following excessive drinking at licensed premises such as hotels and registered clubs. The risk of harm arising from the consumption of alcohol on licensed premises can be reduced by modifying such factors as service of alcohol to intoxicated patrons, service-supply of alcohol to underage patrons, management practices (eg. late closing) and environmental factors (eg. poor lighting). Auditing of licensed premises is an approach currently used by authorities to ensure compliance with licensing requirements. However, such audits do not focus on harm reduction and do not incorporate best practice audit and behaviour change features. No controlled studies have reported the effectiveness of such an audit approach in reducing the risk of violence and crime emanating from hotels and registered clubs. The proposed study aims to assess the effectiveness of a Responsible Hospitality Audit and feedback intervention in reducing service to intoxicated and underage patrons, and in reducing assaults-malicious damage to property following alcohol consumption on licensed premises. The outcomes of this study will be improved responsible service of alcohol actions and reduced alcohol-related crime associated with premises.Read moreRead less