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Discovery Early Career Researcher Award - Grant ID: DE150100406
Funder
Australian Research Council
Funding Amount
$375,936.00
Summary
Cognitive Compensation in Ageing. Decline in cognitive control can have a devastating effect on an individual's capacity to live a high quality and safe independent life. It is an untested assumption that older adults can compensate for age-related changes in cognitive control function to perform at the same level as younger adults. This project aims to be the first to test this widely-held assumption and will examine changes in cognitive control and the emergence of compensation over the adult ....Cognitive Compensation in Ageing. Decline in cognitive control can have a devastating effect on an individual's capacity to live a high quality and safe independent life. It is an untested assumption that older adults can compensate for age-related changes in cognitive control function to perform at the same level as younger adults. This project aims to be the first to test this widely-held assumption and will examine changes in cognitive control and the emergence of compensation over the adult lifespan (20 to 90 years). The project aims to establish whether cognitive compensation is an effective mechanism to maintain cognitive control function into old age and will inform future strategies to help older individuals live more successful and productive independent lives for longer.Read moreRead less
Wellbeing in the elderly: the role of respect. Due to advances in health care, many more Australians are living to old age. It is important to ensure that older people, who comprise a significant proportion of the population, maintain high levels of quality of life (QOL). One of the factors that impact on QOL of older people is the respect afforded to them. This project will determine the issues related to respect for older people in Australia, and produce an evidence-based strategy for encoura ....Wellbeing in the elderly: the role of respect. Due to advances in health care, many more Australians are living to old age. It is important to ensure that older people, who comprise a significant proportion of the population, maintain high levels of quality of life (QOL). One of the factors that impact on QOL of older people is the respect afforded to them. This project will determine the issues related to respect for older people in Australia, and produce an evidence-based strategy for encouraging Australians to adopt more positive attitudes and behaviours related to increasing levels of respect for older people. It is expected that the project will reduce the level of ageism and enhance the status of older people in Australia.Read moreRead less
Managing older driver safe mobility: An international collaboration. The prevalence of medical conditions and impairments in older adults and their likely implications for crashes is considerable and will be an increasing problem into the future without appropriate intervention. There are serious gaps in knowledge about older drivers real-world driving and we cannot reliably predict those most at-risk. Current procedures for assessing driving lack scientific basis and offer clinicians little gui ....Managing older driver safe mobility: An international collaboration. The prevalence of medical conditions and impairments in older adults and their likely implications for crashes is considerable and will be an increasing problem into the future without appropriate intervention. There are serious gaps in knowledge about older drivers real-world driving and we cannot reliably predict those most at-risk. Current procedures for assessing driving lack scientific basis and offer clinicians little guidance about fitness-to-drive. The proposed research offers a comprehensive international collaborative approach to enhance the safe mobility and quality of life of older Australian drivers, through development of evidence-based screening for safe driving, innovative training and other management solutions.Read moreRead less
Glucose facilitation of cognitive function: Effects of effort, age and glucose control. Age-related decline in mental capacity contributes to the economic (estimated at over 2 trillion AUD by 2050), social and human costs of an increasingly older Australian population. The studies in this program aim to understand the role of poor control of blood glucose in age-related cognitive deficits. The role of individual differences in biological (hormonal responses) and psychological (stress and appetit ....Glucose facilitation of cognitive function: Effects of effort, age and glucose control. Age-related decline in mental capacity contributes to the economic (estimated at over 2 trillion AUD by 2050), social and human costs of an increasingly older Australian population. The studies in this program aim to understand the role of poor control of blood glucose in age-related cognitive deficits. The role of individual differences in biological (hormonal responses) and psychological (stress and appetite) factors will also be assessed. A better understanding of the nature of age-related cognitive decline as it relates to biological processes such as blood glucose control will help to develop tangible strategies to combat age-related cognitive decline and dementia (which has been described as Type 3 diabetes).Read moreRead less
Revisiting the 'Fourth Age': health, socioeconomic and cultural transformation of, and diversity in, Australia's oldest old population, 1981-2011. The oldest-old (those aged 85 years and over) is the fastest growing segment of the Australian population, and the changing make-up and experiences of this group needs attention. This project will expand our knowledge base about Australia's oldest old, helping to inform public policy and to improve discussions on what the 'Fourth Age' really means in ....Revisiting the 'Fourth Age': health, socioeconomic and cultural transformation of, and diversity in, Australia's oldest old population, 1981-2011. The oldest-old (those aged 85 years and over) is the fastest growing segment of the Australian population, and the changing make-up and experiences of this group needs attention. This project will expand our knowledge base about Australia's oldest old, helping to inform public policy and to improve discussions on what the 'Fourth Age' really means in Australia.Read moreRead less
Acting with the future in mind. This project seeks to establish whether it is possible to enhance the prospective memory function of healthy older adults. Prospective memory refers to memory for future intentions and is used in many daily activities that are critical for the maintenance of independence in late adulthood, such as remembering to take medication and turn off appliances. The project intends to conduct the first controlled study to use prospective memory activities to directly train ....Acting with the future in mind. This project seeks to establish whether it is possible to enhance the prospective memory function of healthy older adults. Prospective memory refers to memory for future intentions and is used in many daily activities that are critical for the maintenance of independence in late adulthood, such as remembering to take medication and turn off appliances. The project intends to conduct the first controlled study to use prospective memory activities to directly train prospective memory using both major cognitive training approaches: process training (restorative) and strategy training (compensatory). The results should have implications for clarifying how prospective memory function can be optimised in late adulthood, which will be important for healthy ageing.Read moreRead less
The role of P2X7 and P2X4 receptor mediated innate phagocytosis in pathogenesis and treatment of neurodegenerative diseases. This project will identify how inherited variation in two proteins of the brain can accelerate the removal of neurones and predispose to a range of neurodegenerative diseases. Knowledge of the biological basis of this finding will allow a search for new compounds which will slow and protect against this form of neurodegeneration.
Meeting the needs of older persons in Indonesia. The project aims to identify the needs of older people in rural Indonesia for income, housing, health, daily care and social interaction and the extent to which their needs are met. It also considers the efficacy of existing policy programs and how these might be improved. Today, there are 22 million Indonesians aged 60 years and over, projected to rise to 48 million by 2035. Millions of older people live in rural areas from which younger people h ....Meeting the needs of older persons in Indonesia. The project aims to identify the needs of older people in rural Indonesia for income, housing, health, daily care and social interaction and the extent to which their needs are met. It also considers the efficacy of existing policy programs and how these might be improved. Today, there are 22 million Indonesians aged 60 years and over, projected to rise to 48 million by 2035. Millions of older people live in rural areas from which younger people have moved to the rapidly growing cities. This presents challenges for the traditional family-based aged care system in Indonesia. It is expected that findings from the study will be published in a series of policy papers to be presented in the Indonesian National Development Planning Board.Read moreRead less
Improving neuronal cell function with cell permeable copper complexes. Metal-based drugs offer an exciting new approach to treatment of neurodegeneration. However, little is known about how cells metabolise these drugs and this information is critical for further drug development. This project will determine how metal-based drugs are metabolised by neuronal cells and how this may result in therapeutic benefit.
Ageing and the allocation of selective attention over time: behavioural, neurophysiological and neuroanatomical correlates. Only by fully understanding cognitive decline that occurs with age can we hope to provide appropriate interventions to slow or arrest the underlying neural degeneration. Part A, the first of three consecutive parts, will use novel paradigms to investigate various aspects of selective attention and cognition. Part B will investigate the regions of the brain underlying the te ....Ageing and the allocation of selective attention over time: behavioural, neurophysiological and neuroanatomical correlates. Only by fully understanding cognitive decline that occurs with age can we hope to provide appropriate interventions to slow or arrest the underlying neural degeneration. Part A, the first of three consecutive parts, will use novel paradigms to investigate various aspects of selective attention and cognition. Part B will investigate the regions of the brain underlying the temporal allocation of selective attention by comparing the performance of patients with focal lesions, and separately by using event-related potential (ERP) technology. Finally, Part C will evaluate the rate and type of cognitive decline with age using a range of reaction time-independent tasksRead moreRead less