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Improving Decision Making On Health Interventions: Factoring In The Long Term Economic Impacts Of Informal (unpaid) Care
Funder
National Health and Medical Research Council
Funding Amount
$628,963.00
Summary
This project looks at the future health of the Australian population that will keep more informal carers out of employment and diminish their own livings standards, thereby reducing funds available to government and the impact of interventions that could improve the health of the population and increase employment of carers.
Understanding The Experience Of Making Decisions For Persons With Dementia And Their Carers
Funder
National Health and Medical Research Council
Funding Amount
$71,110.00
Summary
This project aims to explore concepts of value, meaning, and experience of the diagnosis amongst sufferers of dementia through discussion of their approach to making care decisions, and reflection on how this dialogue has been conducted with others. These concepts will be assessed from the perspective of diagnosed sufferers, their primary carers and their diagnosing doctors.
Discovery Early Career Researcher Award - Grant ID: DE150100406
Funder
Australian Research Council
Funding Amount
$375,936.00
Summary
Cognitive Compensation in Ageing. Decline in cognitive control can have a devastating effect on an individual's capacity to live a high quality and safe independent life. It is an untested assumption that older adults can compensate for age-related changes in cognitive control function to perform at the same level as younger adults. This project aims to be the first to test this widely-held assumption and will examine changes in cognitive control and the emergence of compensation over the adult ....Cognitive Compensation in Ageing. Decline in cognitive control can have a devastating effect on an individual's capacity to live a high quality and safe independent life. It is an untested assumption that older adults can compensate for age-related changes in cognitive control function to perform at the same level as younger adults. This project aims to be the first to test this widely-held assumption and will examine changes in cognitive control and the emergence of compensation over the adult lifespan (20 to 90 years). The project aims to establish whether cognitive compensation is an effective mechanism to maintain cognitive control function into old age and will inform future strategies to help older individuals live more successful and productive independent lives for longer.Read moreRead less
The Role Of Central Haemodynamics In Type 2 Diabetes Mellitus-related Brain Disease
Funder
National Health and Medical Research Council
Funding Amount
$899,704.00
Summary
Type 2 Diabetes Mellitus is associated with stiffening of major blood vessels which may allow the transmission of harmful pressure to the small vessels of the brain. This may in turn be responsible for damage to brain cells and a greater risk of dementia. This study will use state-of-the art techniques to test this theory. If true, it may open opportunities to reduce the risk of brain disease in diabetes by using therapies to reduce arterial stiffening.
Predicting Health And Disease In Australian Men Over The Age Of 80 Years - The Health In Men Study
Funder
National Health and Medical Research Council
Funding Amount
$528,754.00
Summary
Australia is ageing rapidly but we still do not know whether the risk factors, such as health and lifestyle, that predict ill health in middle aged people, apply to people as they reach old age. This study of a large group of older men will examine the type and level of risk factors that apply to men aged beyond 75 years. It will not only determine rates of disability and mortality but also health service outcomes, including hospitalisation, and residential and community care usage.
Mechanisms Of Oxidised Protein Accumulation In Ageing Cells
Funder
National Health and Medical Research Council
Funding Amount
$429,000.00
Summary
Australia has one of the world's most rapidly ageing populations. It is estimated that in 30 years time over 30% of the population will be over 65; many will suffer from a debilitating, age-related disease. The diseases of ageing represent one of the major health challenges this century. Despite their increasing incidence, our understanding of the underlying causes is limited. A common feature is the accumulation of damaged proteins in cells and tissues. Damaged proteins are usually broken down ....Australia has one of the world's most rapidly ageing populations. It is estimated that in 30 years time over 30% of the population will be over 65; many will suffer from a debilitating, age-related disease. The diseases of ageing represent one of the major health challenges this century. Despite their increasing incidence, our understanding of the underlying causes is limited. A common feature is the accumulation of damaged proteins in cells and tissues. Damaged proteins are usually broken down by the cells and replaced, but in many age-related diseases this process fails. The most common source of protein damage is attack by oxygen-derived free radicals. These are by-products of our body's need for oxygen and can originate from atmospheric pollutants. Oxygen rusts metal, makes fat go rancid and can cause irreparable damage to proteins and other biological molecules. Free radical damage contributes to the development of many age-related diseases such as atherosclerosis and neurodegenerative diseases such as Alzheimer's disease. The accumulation of damaged proteins can cause cell death. Our knowledge of the mechanisms by which cells remove proteins damaged by oxygen and the reasons for their accumulation is limited. In this project we will use a novel technique we have developed to generate oxidised proteins in ageing cells. We will identify cellular mechanisms required for the efficient removal of damaged proteins and those mechanisms which fail in ageing cells. We will focus on a group of proteins which protect damaged proteins from aggregating and accumulating and we will examine how we can prevent the accumulation of oxidised proteins by stimulating the body s defence mechanisms. Since the population of Australia is ageing, diseases of ageing are going to consume an increasing amount of the national health budget. A better knowledge of these cellular mechanisms will allow us to design effective prevention and treatment strategies which are at present lacking.Read moreRead less
Boosting brain plasticity and motor function in older adults. Ageing is associated with a pronounced decline in many motor, cognitive, and other brain functions, but the cause remains elusive. This project will examine the mechanisms that contribute to a decline in brain plasticity and motor function in the elderly. Using novel brain stimulation techniques, the project aims to develop an optimal approach to boost plasticity in the ageing brain and improve motor function. A better understanding o ....Boosting brain plasticity and motor function in older adults. Ageing is associated with a pronounced decline in many motor, cognitive, and other brain functions, but the cause remains elusive. This project will examine the mechanisms that contribute to a decline in brain plasticity and motor function in the elderly. Using novel brain stimulation techniques, the project aims to develop an optimal approach to boost plasticity in the ageing brain and improve motor function. A better understanding of changes in brain function and plasticity with advancing age is expected to help to optimise the design of preventative programs aimed at rejuvenating motor and cognitive function in the elderly.Read moreRead less
Episodic foresight and ageing. Episodic foresight refers to the capacity to imagine future events, and consequently often involves the prediction of future needs based on hypothesised possible outcomes. It is therefore unsurprising that episodic foresight has been consistently linked to independent living and many functional behaviours. The aim of the project is to test the hypothesis that psychological changes brought about by ageing decrease the likelihood of acting prudently with the future i ....Episodic foresight and ageing. Episodic foresight refers to the capacity to imagine future events, and consequently often involves the prediction of future needs based on hypothesised possible outcomes. It is therefore unsurprising that episodic foresight has been consistently linked to independent living and many functional behaviours. The aim of the project is to test the hypothesis that psychological changes brought about by ageing decrease the likelihood of acting prudently with the future in mind. By advancing conceptual understanding of how, and under what circumstances, episodic foresight is affected in late adulthood, the proposed research has important implications for finding ways to help older adults maintain a productive and independent life. Read moreRead less
Ageing, trust, and financial exploitation: social, emotional and cognitive mechanisms. This project aims to understand how age-related differences in the processing of social and emotional information contribute to the exploitation of older adults' trust. This research will examine deception detection during financial negotiations and provide new strategies for ensuring the financial independence and well-being of older Australians.