Identify The Epigenetic And MicroRNA-mediated Mechanisms That Dictate The Mammary Hierarchy In Normal And Neoplastic Breast Cells
Funder
National Health and Medical Research Council
Funding Amount
$302,123.00
Summary
Our aim is to define the epigenetic and microRNA signaling in the breast epithelium cells. This information will contribute to the field’s understanding of the molecular basis of mammary gland development and also reveal novel targets for breast cancer treatment.
Role Of Lamin A-C In Osteoblastogenesis And Age-related Bone Loss
Funder
National Health and Medical Research Council
Funding Amount
$475,515.00
Summary
Osteoporosis prevalence in Australia has increased, especially in the older population. Patients with accelerated aging (Hutchinson Gilford) suffer from severe osteoporosis. A mutation in lamin A-C was identified as the cause of this disease. Therefore it could be the link between aging and bone loss. We will identify the role of lamin in bone biology. We will generate a new understanding of the connection between aging and bone loss and a new potential therapeutic target for senile osteoporosis