Identification Of Target Genes At Breast Cancer-risk Loci With Potential For Drug Repositioning
Funder
National Health and Medical Research Council
Funding Amount
$757,478.00
Summary
Genome wide association studies have been extremely successful at identifying regions of the genome associated with breast cancer risk. However, to fully translate this information to prevention and treatment of breast cancer, we need to understand the molecular mechanisms responsible for increasing breast cancer susceptibility, and the genes that are involved.
Breast And Ovarian Cancer: Beyond Genome Wide Association Studies
Funder
National Health and Medical Research Council
Funding Amount
$863,910.00
Summary
My research is focused on using genetic approaches to understand the basis of cancer, particularly breast and ovarian cancer. Although many risk factors have been identified for these cancers, they do not lend themselves to primary prevention, except for high risk individuals who opt for prophylactic surgery, and so there is an urgent need to understand the aetiology of these cancers in order to develop better risk prediction algorithms and risk reduction medications.
Cancer is a genetic disease – it occurs because of genetic changes in the body that change how a cell grows, and because it occurs more often in people who have an inherited predisposition to cancer. My aim is to uncover more of the genetic events that give rise to cancer, particularly of the breast, ovary and stomach, so that we can identify people at high risk, and advice them accordingly, and also so that we can devise better treatments directed at particular genetic alterations.
Identification Of Novel Genes Predisposing To Male Breast Cancer, Their Prevalence And Associated Cancer Risks.
Funder
National Health and Medical Research Council
Funding Amount
$210,284.00
Summary
Male breast cancer (MBC) is rare and understudied. Using the latest technology, this study will identify new genes which cause familial MBC to aid in the genetic counselling and risk assessment of an affected man and his family. The frequency of these novel genes, and all known breast cancer genes will be assessed in a second group of affected men as well as families with an increased female breast cancer risk. By better understanding the cause of MBC, we can improve its management.
High Resolution Genome-wide SNP Analysis Of Genetic Alterations In Early Ovarian Neoplasms
Funder
National Health and Medical Research Council
Funding Amount
$587,055.00
Summary
Ovarian cancer is the 5th leading cause of cancer death in women. For such a significant disease, remarkably little is know about its origins and this has limited progress in developing more effective diagnostic markers. We will undertake cutting edge genome-wide analysis of pre-invasive ovarian tumours to identify genetic markers relevant to malignancy. This work will significantly expand our understanding of how ovarian cancers develops.
Translation Of Genetic Findings Into Improved Health Outcomes For Common Eye Diseases In Our Society
Funder
National Health and Medical Research Council
Funding Amount
$675,736.00
Summary
Associate Professor Paul Baird of the Centre for Eye Research Australia, University of Melbourne specialises in identifying and understanding how genetic changes are involved in causing the commonest causes of vision loss and blindness in our society including age related macular degeneration, short-sightedness and glaucoma. His Fellowship will be used to better understand how genes and environment cause these diseases, allowing translation of findings intto new and improved treatments for patie ....Associate Professor Paul Baird of the Centre for Eye Research Australia, University of Melbourne specialises in identifying and understanding how genetic changes are involved in causing the commonest causes of vision loss and blindness in our society including age related macular degeneration, short-sightedness and glaucoma. His Fellowship will be used to better understand how genes and environment cause these diseases, allowing translation of findings intto new and improved treatments for patients.Read moreRead less