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The Role Of The Cytosolic Pathogen Recognition Molecule Nod1 In Host Responses To Helicobacter Pylori Infection.
Funder
National Health and Medical Research Council
Funding Amount
$82,753.00
Summary
Helicobacter pylori is the causative agent of gastric ulcers and cancer. However, many questions remain unanswered regarding how H. pylori causes gastric disease. We have recently identified the receptor Nod1 as an important factor in the ability of this bacterium to induce inflammation. The major aim of this project is to investigate the role of Nod1 in the innate and adaptive immune responses to this pathogen.
Bacterial Outer Membrane Vesicles As Immunomodulatory Agents In Helicobacter Pylori Infection
Funder
National Health and Medical Research Council
Funding Amount
$306,510.00
Summary
Chronic inflammation of the stomach is a hallmark of Helicobacter pylori infection, and is a precursor to peptic ulcer disease and cancer. Like many other bacteria, H. pylori sheds spherical blebs from its surface. These blebs bind to stomach cells in vitro and have been found in stomach biopsies of H. pylori-infected subjects. The aims of the work are to investigate the mechanisms whereby H. pylori blebs enter and disseminate within host cells, and how this may contribute to inflammation.