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Identifying, Validating And Exploiting A Novel Dclk1-positive Bipotential Lung Stem Cell
Funder
National Health and Medical Research Council
Funding Amount
$500,648.00
Summary
The discovery of stem cells has changed our understanding and approach to treating chronic diseases. Unlike other organs, the stem cells that maintain and repair the lung remain poorly characterised. I have recently identified a gene that labels a population of cells which contribute to epithelial repopulation of the lung. This project aims to characterise how this population behaves during lung homeostasis and following lung injury, with a view to translating these findings to the clinic.
The Role Of Assembly Factors In Mitochondrial Complex I Biogenesis And Their Defects In Disease.
Funder
National Health and Medical Research Council
Funding Amount
$608,600.00
Summary
Complex I is the first complex of the mitochondrial respiratory chain that is involved in producing most of the cell's energy. Mitochondria diseases occur ~1-5,000 live births with defects in Complex I being the most prevalent, often leading to death. Complex I defects have also been implicated in common disease including Parkinson s disease. This study will provide important new information into how Complex I is built and what goes wrong to cause disease.