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Prospective Study Of The Influence Of Social Networks & School Environments On Emotional Well-being Of Young Adults
Funder
National Health and Medical Research Council
Funding Amount
$202,200.00
Summary
It has become clearer in recent years that the role of the social environment may be as important as individual or interpersonal factors in understanding the risk and protective factors associated with disease prevention. Adolescence is the time when many preventable causes of premature morbidity and mortality arise. It is likely that the social environments encountered during early adolescence will have an impact on the development of emotional and physical well being in early adulthood. This s ....It has become clearer in recent years that the role of the social environment may be as important as individual or interpersonal factors in understanding the risk and protective factors associated with disease prevention. Adolescence is the time when many preventable causes of premature morbidity and mortality arise. It is likely that the social environments encountered during early adolescence will have an impact on the development of emotional and physical well being in early adulthood. This study will prospectively research the impact of school environment and quality of social networks in early adolescence on the emotional well being and health risk behaviours of young adults through the continued surveillance of a cohort of 2,782 students participating in the Gatehouse Project. This cohort has been surveyed four times; twice in Year 8 1997; once in Year 9 1998 and Year 10 1999. In 2002 the cohort will be on average 18 years old and will be first year post-secondary school. The major aim of the study is to investigate the prospective relationships between school environment in early adolescence and the mental and behavioural outcomes for young people in young adulthood. The continued surveillance of this cohort will allow us to assess the long term effects of school environments and adequacy of social networks at early adolescence on the emotional well being and social connectedness of older adolescents. This will contribute to our understanding of risk and protective factors in school-social environments that impact the health and well being of young adults. It will also inform further preventive intervention work that needs to take place in schools and communities to improve health outcomes for young adults.Read moreRead less
Improved Treatment Of Comorbid Anxiety And Depression In Adolescents: A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$275,250.00
Summary
Anxiety and depression are serious mental disorders that affect large numbers of children and adolescents in our community. In particular, young people with both anxiety and depression may experience severe difficulties including poor physical health, social and interpersonal problems, academic problems, drug and alcohol problems, long-term adjustment problems and suicidal behaviour. Although a range of very effective treatments have been developed to treat anxiety and depression separately, the ....Anxiety and depression are serious mental disorders that affect large numbers of children and adolescents in our community. In particular, young people with both anxiety and depression may experience severe difficulties including poor physical health, social and interpersonal problems, academic problems, drug and alcohol problems, long-term adjustment problems and suicidal behaviour. Although a range of very effective treatments have been developed to treat anxiety and depression separately, there is very little work on the treatment of young people with both these problems. Some studies suggest that youth with both anxiety and depression together do worse in currently available treatments, compared to their peers with only a single condition. The current grant seeks to test whether a new treatment addressing both anxiety and depression concurrently, is superior to standard treatments for adolescents experiencing both these emotional problems. It is predicted that the addition of extra components to standard treatments, will result in considerably greater improvements in these more complex cases.Read moreRead less
Identifying Endophenotypes For Eating Disorders And Their Relationship To Specific Genotypes And Environments
Funder
National Health and Medical Research Council
Funding Amount
$507,419.00
Summary
Around 15% of Australian women will have an eating disorder at some time in their life, and half of these will experience significant levels of depression and suicidality. The current project seeks to build better models of the initiation and maintenance of eating disorders that can inform development of effective treatments, with identification of genes and environments that predict the various components that define eating disorders (i.e., behaviours, temperaments and cognitive flexibility).
Risk Factors For The Development Of Eating Disorder Phenotypes And Endophenotypes In Adolescent Twins
Funder
National Health and Medical Research Council
Funding Amount
$266,500.00
Summary
The overall aim of the project is to develop a better understanding of how environment, temperament and genes work together to cause disordered eating and eating disorders. Eating disorders, including anorexia nervosa and bulimia nervosa, are an extremely difficult and costly condition to treat, and are associated with high mortality. Eating disorders in adolescence lead to increased risk for anxiety disorders, chronic fatigue, chronic pain, depressive disorders, infectious diseases, suicide att ....The overall aim of the project is to develop a better understanding of how environment, temperament and genes work together to cause disordered eating and eating disorders. Eating disorders, including anorexia nervosa and bulimia nervosa, are an extremely difficult and costly condition to treat, and are associated with high mortality. Eating disorders in adolescence lead to increased risk for anxiety disorders, chronic fatigue, chronic pain, depressive disorders, infectious diseases, suicide attempts, and limitation in activities due to poor health in adulthood. Full- and partial-syndrome eating disorders affect around 10% of adolescent girls. Given the seriousness of the consequences of eating disorders, and the large number of Australians affected, a better understanding of what causes the development of eating disorders is required. The current research investigates identical and non-identical adolescent female twins aged 13-15 years. As well as examining their eating, this study will look at the sort of environments and temperaments that may increase genetic susceptibility to develop eating problems. The types of environment to be examined include media influence, weight related peer teasing, parental dieting, and pre- and pernatal complications. Twin temperament will also be examined, including perfectionism, sense of ineffectiveness, body dissatisfaction and depression. Parental anxiety and novelty seeking will also be examined for impact on the development of disordered eating in their children. The twins will be followed up over a 2-year period, the peak risk age for onset of eating problems. By comparing the identical and non-identical twins, we can define the characteristics of those most at risk of developing eating problems. The results of this project can be used to formulate specific prevention strategies.Read moreRead less
Economic Evaluation Of PRISM: A Community Based Intervention Trial
Funder
National Health and Medical Research Council
Funding Amount
$512,845.00
Summary
This project evaluates the costs and outcomes of PRISM (Program of Resources, Information and Support to Mothers). PRISM is a community based intervention designed to promote the physical and mental health of mothers. This research project seeks to evaluate the costs and outcomes of the PRISM intervention in order to help inform judgements about its value. PRISM is being introduced in 8 local communities in Victoria with a further 8 communities acting as comparators. The full costs of the interv ....This project evaluates the costs and outcomes of PRISM (Program of Resources, Information and Support to Mothers). PRISM is a community based intervention designed to promote the physical and mental health of mothers. This research project seeks to evaluate the costs and outcomes of the PRISM intervention in order to help inform judgements about its value. PRISM is being introduced in 8 local communities in Victoria with a further 8 communities acting as comparators. The full costs of the intervention will be measured as will the impact the intervention has on the physical and mental health of mothers. Estimates of the intervention's economic benefits, that is the value that community members attach to the intervention's main outcomes will also be ascertained. In this way it is possible to judge whether or not the benefits of PRISM are worth its costs. Advanced statistical techniques will be used to ascertain the extent to which improved health outcomes in mothers are determined by individual, organisational or community-level factors.Read moreRead less
Modifiable Influences On Tobacco, Cannabis And Other Drug Use In Early Adolescence.
Funder
National Health and Medical Research Council
Funding Amount
$198,434.00
Summary
High rates of tobacco and cannabis use by Australia s young people are a continuing concern. This study will explore the factors that influence the development of drug use from late childhood. The International Youth Development Study collected data from 5,769 students in Grades 5, 7, and 9 in Washington State, U.S., and Victoria, Australia. Findings will both increase understanding of adolescent tobacco and cannabis use in the Australian context and inform prevention policy.
A Comparative Structural And Functional Cerebral MRI Study Of First Episode Schizophrenia And Long-term Cannabis Use.
Funder
National Health and Medical Research Council
Funding Amount
$373,125.00
Summary
Cannabis is used for its subjective effects that include euphoria, depersonalisation, somnolence, and altered perceptions of temporal contingency.It is a controlled substance yet one quarter of Australian adolescents and seven percent of adults use cannabis regularly. Chronic use of cannibis can impair frontal brain functioning, affecting the capacities for attention, working memory and concentration.These neurocognitive deficits bear striking similarities to those associated with the negative s ....Cannabis is used for its subjective effects that include euphoria, depersonalisation, somnolence, and altered perceptions of temporal contingency.It is a controlled substance yet one quarter of Australian adolescents and seven percent of adults use cannabis regularly. Chronic use of cannibis can impair frontal brain functioning, affecting the capacities for attention, working memory and concentration.These neurocognitive deficits bear striking similarities to those associated with the negative symptom cluster of schizophrenia,which is related to frontal brain dysfunction. The proposed study will be the first of it's kind to apply sophisticated neuroimaging techniques to investigate how long-term adolescent cannabis use effects the structure and function of the brain and to make comparative analyses with the brain changes associated with first episode schizophrenia. We predict that structural brain abnormalities that are consistent in localisation, if not in degree, will be detected in long-term cannabis using and first episode schizophreniaparticipants and that there will be even more profound abnormalities in the first episode schizophrenia cannabis users. We will use the Tower of London (TOL) task to activate certain areas associated with executive functioning (for instance attention, memory, and strategic planning). Here, we expect lower intensity activation of the prefrontal cortex during TOL performance both in the cannabis and first episode schizophrenia groups and that the activation will be lowest of all for the cannabis using first episode schizophrenia group. The methodology to be applied in this study offers a unique opportunity to enhance our understanding of the structural and functional markers of first episode schizophrenia and cannabis use in the neural substrate.Read moreRead less
Re-orientating General Practice Systems Toward Youth Friendly Care: A Cluster Randomized Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,387,497.00
Summary
This project aims to improve young people's health care by helping general practice become youth friendly and measuring the effects of this on: willingness to visit for mental health and risky behaviours such as tobacco, alcohol and other drug use and unprotected sex; parents' perceptions of the care received; the sense of competence staff have in dealing with young people's issues; the practice's effectiveness in responding to young people's health risks and on the cost of general practice.
Early Life Stress, Adolescent Brain Development And Risk For Adverse Cognitive And Psychosocial Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$640,595.00
Summary
This project aims to study pre and postnatal childhood factors and examine their association with HPA-functioning, cognition, and mental health during adolescence in the Western Australian Pregnancy Cohort Study (Raine Study). Childhood exposures include not only trajectories of stressful life events, family functioning and mental health status during childhood, but also effects of intrauterine and postnatal growth patterns, and a comprehensive range of psychosocial, familial and environmental f ....This project aims to study pre and postnatal childhood factors and examine their association with HPA-functioning, cognition, and mental health during adolescence in the Western Australian Pregnancy Cohort Study (Raine Study). Childhood exposures include not only trajectories of stressful life events, family functioning and mental health status during childhood, but also effects of intrauterine and postnatal growth patterns, and a comprehensive range of psychosocial, familial and environmental factors. It is our objective to characterise functional polymorphisms for genes related to stress regulation and examine their interactions with early life exposures and their neurobiological consequences. We will also test 16 year old Raine subjects for cognitive ability, and in some we will image their brain activity while performing these tests. We anticipate to enhance the already comprehensive phenotypic Raine Study data base with neurobiological information for future neuroscience studies as the Raine cohort matures. We hypothesise that increased and sustained trajectories of early life stress, family dysfunction or poor mental health during childhood will increase the risk of Raine Study adolescents experiencing: (i) - increased stress sensitivity with higher baseline cortisol levels during adolescence; (ii) - increased adolescent stress sensitivity, if they are carriers of specific haplotypes of the glucocorticoid and mineralocorticoid receptor genes.;(iii) - depression during adolescence, if they are homozygous or heterozygous for the short allele of the serotonin transporter (5-HTT) gene; (iv) - poorer cognitive performance and increased atypical non-prefrontal cortex (PFC) brain activity during cognitive testing as measured by fMRI; and (v) -more mental health problems during adolescence.Read moreRead less