A Window Of Vulnerability: Impaired Fear Inhibition In Adolescent Rats
Funder
National Health and Medical Research Council
Funding Amount
$335,849.00
Summary
Adolescence is a period of increased vulnerability to anxiety disorders. The brain undergoes substantial maturation during adolescence, particularly the prefrontal cortex (PFC), a region critical for inhibiting fear. This project examines why fear inhibition is impaired in adolescents and compares the neural mechanisms mediating treatments that enhance fear reduction in adolescence. This research adds new knowledge about novel approaches for early interventions for adolescent anxiety.
The GOOD NIGHT Project: A Sleep Intervention To Prevent Depression And Improve Cardiac Health In Adolescence
Funder
National Health and Medical Research Council
Funding Amount
$902,741.00
Summary
There is a pressing need for effective approaches to preventing depression during adolescence. The primary aim of the project is to assess whether a brief sleep intervention can prevent depression in vulnerable adolescents. Given that sleep interventions also encourage daytime activity, which when combined with improved sleep has potential benefits for cardiovascular health, the secondary aim is to test whether the sleep intervention improves early indicators of cardiovascular risk.
Preclinical Investigation Into Novel Therapeutics To Treat Drug Abuse During Adolescence And Adulthood
Funder
National Health and Medical Research Council
Funding Amount
$713,684.00
Summary
To investigate early life drug abuse and its treatment, drug-consumption and seeking behaviour will be examined in adolescent rats. We expect dopamine immaturity during adolescence to be a critical factor in persistence of drug-seeking in adolescence.
Clinical And Psychosocial Changes Over Late Childhood And Adolescence And Early Life Determinants Of Long Term Clinical Outcomes In Cystic Fibrosis
Funder
National Health and Medical Research Council
Funding Amount
$1,135,570.00
Summary
Cystic fibrosis is the most common life shortening inherited disease in Caucasians. Lung damage starts in infancy and lung function falls most rapidly in adolescence although why and how this happens and early life determinants are not known. This study takes advantage of a previous study that monitored young children from 3 months to 5 years of life and follows them closely through early adolescence to investigate the protective and risk factors for falling lung function.
Investigating The Interaction Between BDNF And Sex Steroid Hormones During Adolescent Development: Relevance To Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$449,048.00
Summary
Schizophrenia first appears clinically during late adolescence. Sex hormones as well as growth factors such as Brain derived neurotrophic factor (BDNF) are involved in shaping the adolescent brain to its adult form. Alterations to these systems may contribute to structural changes seen in schizophrenia. This project will investigate the interaction of BDNF and sex hormones in the development of the adolescent mouse brain, and behavioural responses with relevance to schizophrenia.
Increasing The Efficacy Of Treatment For Socially Anxious Youth Through Theoretically Derived Improvements
Funder
National Health and Medical Research Council
Funding Amount
$971,747.00
Summary
Social anxiety has a severe impact on young people. Although we have good treatments for most anxious youth, those with social anxiety show the least change. The proposed project will evaluate the benefits of a new treatment for socially anxious young people based on current understanding of the causes of this disorder. The new treatment will have better effects than traditional therapy and will lead to increased knowledge of the causes of this disorder.
Patterns Of Care And Experience Of Care For Adolescents And Young Adults With Cancer
Funder
National Health and Medical Research Council
Funding Amount
$669,096.00
Summary
There is increasing concern, across several countries, that outcomes of care for adolescents and young adults (AYAs) with cancer are not optimal. This project aims to improve outcomes of care for AYAs with cancer by providing information about the best way to organise health services. It will do this by describing patterns of care for 700 AYA patients with cancer; providing detailed data on experiences with care for 300 patients; and conducting in-depth qualitative interviews.
Pubertal Transitions In Mental Health And Behaviour: The PHASE-A Study Of Social Roleand Lifestyle Transitions
Funder
National Health and Medical Research Council
Funding Amount
$1,656,785.00
Summary
Over the past four decades problems such as depression, anxiety, self-harm and substance abuse have increased in young people. Recent research indicates that puberty is a time when these problems commonly first emerge. This five-year study of 4000 students will examine a question of whether social transitions that are too soon (e.g. early initiation of sex) or problematic (e.g. bullying from peers) may explain the increase in these health problems as children pass through puberty.
Adolescent Rural Cohort Study Hormones, Health, Education, Environments And Relationships
Funder
National Health and Medical Research Council
Funding Amount
$1,016,983.00
Summary
Adolescence is a time of major physical, emotional and social change, often characterised by risk taking and experimentation. Behaviours and decisions taken at this time of life will shape future health. This rural cohort study will for the first time will study the influence of pubertal hormones on behaviours, mental and physical health and general well being in adolescents.