Identifying An Autism Gene Network Governing Stem Cell Division, Neurogenesis And Cortical Malformation
Funder
National Health and Medical Research Council
Funding Amount
$1,003,589.00
Summary
Failure to produce neural stem cells and new neurons in the embryonic cortex results in cortical malformations and autism, and thus has profound consequences for the individual's survival and quality of life. Here we explore how a unique network of autism proteins maintains stem cell activity and neuronal production, thereby ensuring the fidelity of cortical development.
The rapid interactions of circulating human blood platelets is critical to prevent bleeding, but can cause thrombotic diseases (heart attack, stroke). These highly regulated interactions involve specific adhesive proteins. Our studies will define factors regulating platelet interactions. Imaging the thrombotic process will quantify platelet function at an unprecedented resolution and we have a panel of new candidate reagents that will be assessed for antithrombotic potential.