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Modulating COVID-19 Disease By Targeting Virus And Virus-induced Responses Through Pharmaceutical And Mechanical Ventilation Strategies: SARS-CoV-2 S-protein, ACE2 And TMPRSS2
Funder
National Health and Medical Research Council
Funding Amount
$628,856.00
Summary
COVID-19 is a current global pandemic that is likely to be an on-going threat. We need a multipronged strategy to combat COVID-19, including therapeutic anti-virals and clinical practice management strategy. We will address both these points to define the mechanisms triggering disease, test existing drugs targeting androgens and modify the way doctors use ventilators to treat COVID-19 disease in the intensive care unit. Outcomes will have impact beyond COVID-19 for managing viral lung disease.
We are studying human amnion epithelial cells (AECs) as a new therapy for stroke. Here if we find the protective effects of AECs are unaffected by a 'clot-buster' drug,we will broaden our planned Phase II trial of AECs to include patients that have received clot lysis therapy. Further, as we suspect that AECs exert their effects via release of nanoparticles called 'exosomes', we will test whether exosomes given intravenously or intranasally are similarly protective.
Molecular Regulators Of Adaptive Immunity To Overwhelming Viral Infections
Funder
National Health and Medical Research Council
Funding Amount
$786,898.00
Summary
Diseases caused by overwhelming viral infections, such as COVID-19, are associated with widespread impairments in immunity and constitute a major burden to human health. We have discovered that the molecule c-Myb is essential for the maintenance of immunity during chronic infection. In order to lay the foundations for novel and innovative anti-viral therapies, this project will dissect the molecular pathways regulated by c-Myb that maintain immunity during severe or chronic infection.
Oncogenic Determinants Of The Immune Response In Acute Myeloid Leukaemia
Funder
National Health and Medical Research Council
Funding Amount
$588,144.00
Summary
There is an urgent need to develop new therapies for patients with AML. We have shown that the body's own immune system can target certain types of AML. We will determine how these types of AML change to escape control from the immune system and how this can be reversed to re-engage the anti-AML immune response. Using patient samples, we will determine how the anti-AML immune response changes during the course of standard therapy in order to best combine it with immune-targeted therapies.
Communication Connect: Improving Long Term Communication And Mental Health Outcomes Following Stroke And Brain Injury
Funder
National Health and Medical Research Council
Funding Amount
$1,809,756.00
Summary
The 250,000 Australians living in the community with communication disability caused by stroke and traumatic brain injury experience unacceptably high rates of depression, anxiety, inactivity and social isolation. Their carers experience high levels of burden, and they struggle to access health and community services. We aim to develop and test a program of community and self-managed care, aimed at reversing these negative impacts and reducing reliance on high cost health care services.
Leaving No-one Behind: Informing Indigenous Aged Care Policy With Big Data.
Funder
National Health and Medical Research Council
Funding Amount
$1,668,851.00
Summary
Very little is known about older Indigenous people in aged care. Led by Indigenous people, this project will use a unique national dataset to answer questions on the experiences of Indigenous people in aged care, focusing on access and barriers to services and care, quality and safety of care and whether the care they receive meets their health needs. This research will inform service improvements and ensure older Indigenous people are not forgotten in much-needed aged care reforms.
Advancing Equitable And Non-discriminatory Access To Health Services For First Nations Peoples: A Multidisciplinary Queensland Human Rights Act Case Study
Funder
National Health and Medical Research Council
Funding Amount
$1,279,602.00
Summary
The objective of this innovative study is to apply a multidisciplinary, right to health lens to critically explore & bring to light Indigenous Australians' experiences of racial discrimination in accessing equitable, quality & timely health services in urban, rural & remote locations. Research outcomes will be synthesised into a suite of project deliverables, with Multi-Stakeholder Advisory Group guidance & community co-design, to advance inter-generational health justice.