Using chemistry to illuminate sulfoglycolysis, a major organosulfur pathway. This project aims to develop a detailed molecular description of the sulfoglycolysis pathway, a major pathway involved in cycling an abundant sulfolipid. The project will use an integrated chemical, biochemical and structural approach to illuminate how sulfoglycolysis degrades sulfolipid to access its elemental and energy constituents. Expected outcomes include an advanced understanding of the biosulfur cycle, the devel ....Using chemistry to illuminate sulfoglycolysis, a major organosulfur pathway. This project aims to develop a detailed molecular description of the sulfoglycolysis pathway, a major pathway involved in cycling an abundant sulfolipid. The project will use an integrated chemical, biochemical and structural approach to illuminate how sulfoglycolysis degrades sulfolipid to access its elemental and energy constituents. Expected outcomes include an advanced understanding of the biosulfur cycle, the development of new chemical approaches to manipulate sulfur cycling for agricultural and biotechnology applications, and deepened ties to leading international researchers. Potential benefits include new strategies to reduce dependence on agricultural fertilisers, promote gut wellbeing, and control insect pests.Read moreRead less
Dissecting a major sulfur cycling pathway: sulfoglycolysis. This project will elucidate the molecular details of sulfoglycolysis, a group of metabolic pathways through which the sulfur-containing sugar sulfoquinovose is catabolized. The project will employ an integrated metabolomic, chemical, biochemical and structural approach to dissect how various sulfoglycolytic organisms degrade sulfoquinovose. This project will deliver a deeper understanding of this major biochemical pathway and develop ne ....Dissecting a major sulfur cycling pathway: sulfoglycolysis. This project will elucidate the molecular details of sulfoglycolysis, a group of metabolic pathways through which the sulfur-containing sugar sulfoquinovose is catabolized. The project will employ an integrated metabolomic, chemical, biochemical and structural approach to dissect how various sulfoglycolytic organisms degrade sulfoquinovose. This project will deliver a deeper understanding of this major biochemical pathway and develop new chemical and metabolic approaches to manipulate sulfur cycling in the environment. Benefits will include biotechnology applications of newly discovered proteins, and sustainable approaches to reduce our dependence on agricultural fertilisers.Read moreRead less