Novel antimicrobial surface coatings for Cochlear implants. The objective of this project is to develop new antimicrobial coatings for materials used to manufacture biomedical devices. Infection associated with the use of biomaterials such as biomedical implants, catheters and orthopaedic prostheses is a major barrier to the use of these devices. The coatings that the project plans to develop are based on novel antimicrobials which have been shown to prevent adhesion and colonisation of biomater ....Novel antimicrobial surface coatings for Cochlear implants. The objective of this project is to develop new antimicrobial coatings for materials used to manufacture biomedical devices. Infection associated with the use of biomaterials such as biomedical implants, catheters and orthopaedic prostheses is a major barrier to the use of these devices. The coatings that the project plans to develop are based on novel antimicrobials which have been shown to prevent adhesion and colonisation of biomaterials by bacteria in vivo. This strategy has the potential to prevent device-related infections and revolutionise the biomaterials industry.Read moreRead less
Novel antimicrobial surface coatings for biomedical applications. There are currently no effective biomaterial coatings to reduce device related infections. Such materials are needed to address the high rates of infection that can occur. The melimine technology proposed here has the potential to significantly reduce rates of infection, reduce health care costs and advantage the Australian biomaterials industry.
Developing a multicomponent platform for targeted gene delivery. Gene delivery systems are important tools in biological research and offer many exciting future prospects. Delivering gene material is very difficult in practice: rapid deterioration, poor cell uptake, and reaching the right tissue and cell types are major obstacles. Ways to overcome each barrier individually have been suggested in existing research but these components have not yet been combined in a single solution, which this pr ....Developing a multicomponent platform for targeted gene delivery. Gene delivery systems are important tools in biological research and offer many exciting future prospects. Delivering gene material is very difficult in practice: rapid deterioration, poor cell uptake, and reaching the right tissue and cell types are major obstacles. Ways to overcome each barrier individually have been suggested in existing research but these components have not yet been combined in a single solution, which this project will tackle. This proposal aims to create a technology to stabilise and deliver active gene material to target cells. The gene delivery tool developed in this project will advance biological research greatly with many potential future applications.Read moreRead less
Antimicrobial contact lens cases. Contamination of contact lens cases is now recognised as a major risk factor driving the incidence of corneal infections during contact lens wear. This project will develop novel antimicrobial materials for manufacture of lens cases for the prevention of infections associated with contact lens wear.
Development of a multicomponent delivery system for oligonucleotides. Gene therapy has the ability to prevent faulty genes from causing disease, however the ability to deliver genetic material into specific cells remains a major barrier. Our research will overcome this hurdle by generating systems that are superior to existing technologies.