Discovery Early Career Researcher Award - Grant ID: DE180100418
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Novel chemical tools to study cathepsin X activation. This project aims to develop new chemical tools that can measure the specific activation of cathepsin X in cells, tissues, and live animals, as well as specific inhibitors for cathepsin X. The cysteine protease cathepsin X mediates basic biological functions that are essential for life, including cell communication, phagocytosis, immune maturation and neuritogenesis. The outcomes should benefit the wider research community. They could have lo ....Novel chemical tools to study cathepsin X activation. This project aims to develop new chemical tools that can measure the specific activation of cathepsin X in cells, tissues, and live animals, as well as specific inhibitors for cathepsin X. The cysteine protease cathepsin X mediates basic biological functions that are essential for life, including cell communication, phagocytosis, immune maturation and neuritogenesis. The outcomes should benefit the wider research community. They could have long-term implications for health and disease, and deliver economic benefits through commercialisation of the novel tools.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC230100046
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Training Centre for Radiochemical Technologies and Precision Radiopharmaceuticals. This project aims to train the next generation of radiochemists and discover new molecular approaches to harness radioactivity. Novel chemistry exploiting molecular incorporation of radioactive elements, stable chelation of metal radionuclides, bioconjugation methodologies, radioactivity capture via nanomaterials and cages, and the design of new peptidomimetic targeting molecules will deliver technological adv ....ARC Training Centre for Radiochemical Technologies and Precision Radiopharmaceuticals. This project aims to train the next generation of radiochemists and discover new molecular approaches to harness radioactivity. Novel chemistry exploiting molecular incorporation of radioactive elements, stable chelation of metal radionuclides, bioconjugation methodologies, radioactivity capture via nanomaterials and cages, and the design of new peptidomimetic targeting molecules will deliver technological advances to radiopharmaceutical science. Outcomes will include a highly-skilled workforce and enhanced commercial capacity to meet a rapidly escalating global radiopharmaceutical market. This project will provide significant benefits by securing an internal supply chain and know-how for cutting-edge radiochemical technologies.Read moreRead less
Mixing the jigsaw pieces of natural products: new molecules-new properties. This project aims to examine the capacity of exploiting the bacterial biosynthetic machinery to fast-track access to analogues of natural products. Due to increased drug resistance, new reservoirs of natural products are needed for evaluation as future drugs. Desferrioxamine B will be used as a model natural product to establish the biosynthesis of new analogues in bacterial culture supplemented with unsaturated, fluorin ....Mixing the jigsaw pieces of natural products: new molecules-new properties. This project aims to examine the capacity of exploiting the bacterial biosynthetic machinery to fast-track access to analogues of natural products. Due to increased drug resistance, new reservoirs of natural products are needed for evaluation as future drugs. Desferrioxamine B will be used as a model natural product to establish the biosynthesis of new analogues in bacterial culture supplemented with unsaturated, fluorinated or deuterated building blocks. The intended outcomes are to deliver advances in methods for generating structurally diverse pools of natural products, new label-free probes, knowledge of natural product biosynthesis, and excellence in training research students in frontier methods in chemical biology and drug discovery.Read moreRead less
Control of immune recognition and response by microbial metabolites. This project aims to study immune recognition of microbial metabolites and develop reagents to control immune responses. Chemical synthesis will be used to develop new antigens for unconventional T cells and the first soluble agonists and antagonists of a glycolipid-sensing immune receptor. Expected outcomes include the discovery of new immune effectors, broadening our knowledge of the repertoire of small molecules that can be ....Control of immune recognition and response by microbial metabolites. This project aims to study immune recognition of microbial metabolites and develop reagents to control immune responses. Chemical synthesis will be used to develop new antigens for unconventional T cells and the first soluble agonists and antagonists of a glycolipid-sensing immune receptor. Expected outcomes include the discovery of new immune effectors, broadening our knowledge of the repertoire of small molecules that can be sensed by the immune system, and developing chemical approaches to promote or dampen immune responses. Major benefits include research training in chemical biology, strengthened international linkages and fundamental insights into the chemical basis of immune recognition and response.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100148
Funder
Australian Research Council
Funding Amount
$1,350,000.00
Summary
Advanced Nuclear Magnetic Resonance Technologies for Southeast Queensland. This project aims to establish an advanced Nuclear Magnetic Resonance capability and capacity at two of Queenslands' leading research intensive universities. The project expects to enhance the scope and productivity of hundreds of research projects spanning natural products, synthetic, medicinal, materials and environmental science. Expected outcomes include smarter science, more productive collaborations and superior res ....Advanced Nuclear Magnetic Resonance Technologies for Southeast Queensland. This project aims to establish an advanced Nuclear Magnetic Resonance capability and capacity at two of Queenslands' leading research intensive universities. The project expects to enhance the scope and productivity of hundreds of research projects spanning natural products, synthetic, medicinal, materials and environmental science. Expected outcomes include smarter science, more productive collaborations and superior research training, leading to innovative solutions to challenging problems that confront science and society. This investment should provide significant benefits in the form of new knowledge across multiple disciplines, informing the design of future medicines, agrochemicals, materials and other products.
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Developing a multicomponent platform for targeted gene delivery. Gene delivery systems are important tools in biological research and offer many exciting future prospects. Delivering gene material is very difficult in practice: rapid deterioration, poor cell uptake, and reaching the right tissue and cell types are major obstacles. Ways to overcome each barrier individually have been suggested in existing research but these components have not yet been combined in a single solution, which this pr ....Developing a multicomponent platform for targeted gene delivery. Gene delivery systems are important tools in biological research and offer many exciting future prospects. Delivering gene material is very difficult in practice: rapid deterioration, poor cell uptake, and reaching the right tissue and cell types are major obstacles. Ways to overcome each barrier individually have been suggested in existing research but these components have not yet been combined in a single solution, which this project will tackle. This proposal aims to create a technology to stabilise and deliver active gene material to target cells. The gene delivery tool developed in this project will advance biological research greatly with many potential future applications.Read moreRead less
Chemical probes to dissect the cell cycle of globally important parasites . This project aims to develop new reagents, called chemical probes, to visualise key biological events in globally important pathogens. We will use innovative chemistry to modify the building blocks of DNA and provide researchers with essential tools to 'see' DNA synthesis in order to study growth and replication of pathogens in combination with microscopy. This project expects to support a major technical advance that wi ....Chemical probes to dissect the cell cycle of globally important parasites . This project aims to develop new reagents, called chemical probes, to visualise key biological events in globally important pathogens. We will use innovative chemistry to modify the building blocks of DNA and provide researchers with essential tools to 'see' DNA synthesis in order to study growth and replication of pathogens in combination with microscopy. This project expects to support a major technical advance that will address important gaps in our understanding of many pathogens (e.g. those that cause malaria and tuberculosis), at both the cellular and molecular levels. This should provide significant benefits by enabling researchers worldwide to identify new intervention opportunities that target unique aspects of pathogen biology.Read moreRead less