New strategies for the stereoselective synthesis of Stemona alkaloids and the discovery of new bioactive molecules. The project aims to develop innovative methods to prepare bioactive natural products and their analogues with potential applications as new and safer therapeutic drugs and agricultural chemicals. These products would be of benefit to Australians in the future.
Characterisation of the beneficial vs toxic forms of selenium in the diet. This project aims to examine how dietary selenium is converted into essential proteins and beneficial compounds that mitigate against a broad range of human diseases; or alternatively, into toxic molecules. Cutting-edge methodologies should resolve significant unknowns in selenium metabolism, to provide definitive dietary guidelines and to explore how selenium can treat and protect against disease. Expected outcomes from ....Characterisation of the beneficial vs toxic forms of selenium in the diet. This project aims to examine how dietary selenium is converted into essential proteins and beneficial compounds that mitigate against a broad range of human diseases; or alternatively, into toxic molecules. Cutting-edge methodologies should resolve significant unknowns in selenium metabolism, to provide definitive dietary guidelines and to explore how selenium can treat and protect against disease. Expected outcomes from this national and international collaboration include expert training for young biochemical researchers and refinements to novel analytical techniques. Results should benefit the food and agricultural sectors to provide tailored products locally and for export, as well as enhanced health opportunities for all Australians.Read moreRead less
Taking nature's lead in the development of new and improved enzyme inhibitors. This project will address some key fundamental issues associated with advancing a chemical entity from proof of principle through to a new pharmaceutical. The compounds in the study target cancer, cataract and other diseases that are confronting Australia's ageing population.