Sequence to Sequence: Rigorous Statistical and Mathematical Analysis of Biological Sequence Data. Comparative genomics is fundamental for developing an understanding of genes and their function. For example, using statistical and computational techniques, it was recently demonstrated that 60% of genes are conserved between fly and human. When the human gene that confers susceptibility to Parkinson's disease was transferred into the fly it caused symptoms similar to those seen in humans. The futu ....Sequence to Sequence: Rigorous Statistical and Mathematical Analysis of Biological Sequence Data. Comparative genomics is fundamental for developing an understanding of genes and their function. For example, using statistical and computational techniques, it was recently demonstrated that 60% of genes are conserved between fly and human. When the human gene that confers susceptibility to Parkinson's disease was transferred into the fly it caused symptoms similar to those seen in humans. The future development of 'personalized medicine' will rely upon understanding the function of human genes, as will progress in the agricultural sector. Rigorous statistical analysis and development of appropriate bioinformatic methods are crucial to biological sequence analysis in comparative genomics.Read moreRead less
Statistical Advances in the Post-Genome Era. Biologically relevant statistical foundations for post-genome biology and biotechnology will be developed. Specific goals of the topics include the development of accurate and more efficient algorithms for sequence alignments, improved models to maximise the accuracy of analyses for gene expression data and superior statistical methods for identification of complex gene networks that predispose an organism to disease. The Project will make significant ....Statistical Advances in the Post-Genome Era. Biologically relevant statistical foundations for post-genome biology and biotechnology will be developed. Specific goals of the topics include the development of accurate and more efficient algorithms for sequence alignments, improved models to maximise the accuracy of analyses for gene expression data and superior statistical methods for identification of complex gene networks that predispose an organism to disease. The Project will make significant contributions to the new and evolving priority research area of Bioinformation Science (including bioinformatics). Outcomes will include novel techniques for analysis and mining of post-genome data, with applications to developments in Bio-medicine and Bio-agricultureRead moreRead less
Digital Outsourcing in Architecture: Opportunities for Australian Firms or Perils for Australian Workforce? This research will help assess competitiveness and viability of different digital outsourcing practices in connection to the needs, the operative conditions and the products of the Australian building design sector. The information will give industry analysts a tool to identify the markets within which these arrangements are likely to spread or occur in the future, and take consequent corr ....Digital Outsourcing in Architecture: Opportunities for Australian Firms or Perils for Australian Workforce? This research will help assess competitiveness and viability of different digital outsourcing practices in connection to the needs, the operative conditions and the products of the Australian building design sector. The information will give industry analysts a tool to identify the markets within which these arrangements are likely to spread or occur in the future, and take consequent corrective or supportive action. The outcomes of this project will benefit Australia by forecasting changes in professional employment prospects, and by providing a framework to consider development scenarios for architectural educational and professional institutions, national research and development priorities, and international trade agreement agendas.Read moreRead less
Conserving native wildlife during urbanisation: the effectiveness of biodiversity-friendly urban design and construction practices. Urbanisation has many negative effects upon native wildlife and their habitats, but biodiversity-friendly urban design and construction practices may greatly reduce these impacts. This study will examine the effectiveness of such measures at sustaining wildlife at sites of urban development, and will therefore produce significant benefits for local residents and the ....Conserving native wildlife during urbanisation: the effectiveness of biodiversity-friendly urban design and construction practices. Urbanisation has many negative effects upon native wildlife and their habitats, but biodiversity-friendly urban design and construction practices may greatly reduce these impacts. This study will examine the effectiveness of such measures at sustaining wildlife at sites of urban development, and will therefore produce significant benefits for local residents and the broader Australian community. Healthy natural ecosystems in urban areas provide many services to the public, reduce the need for costly management, and improve the livelihood of residents living in greener environments. This study will enhance all these community benefits through a detailed examination of the effectiveness of biodiversity-friendly urban development measures.Read moreRead less
Management of Complex Assets Using Smart Information Systems. The aim is to develop an integrative framework and a smart system for holistic asset management in order to manage and optimise asset decisions vis-a-vis shifts in customer and market needs. It will develop an advanced conceptual framework, a dedicated smart system that is capable of handling uncertainty often associated with decision making in large complex operations. The benefits of this research are: a more competitive indusry wit ....Management of Complex Assets Using Smart Information Systems. The aim is to develop an integrative framework and a smart system for holistic asset management in order to manage and optimise asset decisions vis-a-vis shifts in customer and market needs. It will develop an advanced conceptual framework, a dedicated smart system that is capable of handling uncertainty often associated with decision making in large complex operations. The benefits of this research are: a more competitive indusry with focus on markets; a smart system to demonstrate business-based decision making and generally a much more sophisticated approach to asset management.Read moreRead less
The rise of empiricism and the attempt to produce a unified understanding of the world, 1680-1750. Empiricism is often regarded as the characterising feature of modern scientific method, and, in those approaches to psychology and the social and economic sciences that seek to model themselves on successful scientific practice in the physical and life sciences, it often acts as a model of good practice. The project examines the original form of empiricism and shows how it was able to directly enga ....The rise of empiricism and the attempt to produce a unified understanding of the world, 1680-1750. Empiricism is often regarded as the characterising feature of modern scientific method, and, in those approaches to psychology and the social and economic sciences that seek to model themselves on successful scientific practice in the physical and life sciences, it often acts as a model of good practice. The project examines the original form of empiricism and shows how it was able to directly engage questions of value in a novel and revealing way, and how its connection with 'hard' sciences was not merely to provide a methodological gloss on these, but went to the core of what scientific explanation consisted in.Read moreRead less
Tracing the origins of stress in the symbionts of reef-building corals. Symbiotic dinoflagellates of corals are critical to the world's major tropical reef ecosystems. Recent work in our laboratories and others has revealed that these algae are sensitive to a wide array of stresses (including climate change) and hence may be the ?Achilles Heel? of reef ecosystems. This project will identify the key genes and processes in these algae using expressed sequence tags and microarray technology. On th ....Tracing the origins of stress in the symbionts of reef-building corals. Symbiotic dinoflagellates of corals are critical to the world's major tropical reef ecosystems. Recent work in our laboratories and others has revealed that these algae are sensitive to a wide array of stresses (including climate change) and hence may be the ?Achilles Heel? of reef ecosystems. This project will identify the key genes and processes in these algae using expressed sequence tags and microarray technology. On this basis, the underlying molecular mechanisms of these stress responses and their genetic diversity will be studied in order to better understand the differential susceptibility of reef-building corals to bleaching.Read moreRead less
From tourist siren to technological beacon: analysing the industrial function of the Sydney Opera House thirty years after its completion. The research will show that public buildings provide fertile ground to plant industrial seeds; but to have an impact on the local economy, they must respond to specific structural conditions or be supported by political will. These findings will improve Australia's institutional understanding of the relationship between cost and investment in construction, an ....From tourist siren to technological beacon: analysing the industrial function of the Sydney Opera House thirty years after its completion. The research will show that public buildings provide fertile ground to plant industrial seeds; but to have an impact on the local economy, they must respond to specific structural conditions or be supported by political will. These findings will improve Australia's institutional understanding of the relationship between cost and investment in construction, and clarify that the evaluation of building productivity requires a long-term perspective. Government agencies should use institutional projects to define their public face but also to plan and implement industrial strategies. The research will help Australia maximise its creative and technological capability by understanding the factors conducive to innovation and its acceptance.Read moreRead less
Mathematics, the science of real structure: an Australian realist philosophy of mathematics. The project will strengthen the already strong Australian philosophical tradition of realism, extending it into philosophy of mathematics. It will develop a robust alternative to the nominalism, Platonism and idealism that dominate northern-hemisphere philosophizing about mathematics, an alternative that is in tune with how mathematicians really apply mathematics. Australian philosophy will thus be stren ....Mathematics, the science of real structure: an Australian realist philosophy of mathematics. The project will strengthen the already strong Australian philosophical tradition of realism, extending it into philosophy of mathematics. It will develop a robust alternative to the nominalism, Platonism and idealism that dominate northern-hemisphere philosophizing about mathematics, an alternative that is in tune with how mathematicians really apply mathematics. Australian philosophy will thus be strengthened in general, giving it a greater attractiveness to the many overseas visitors and students who already appreciate its unique strengths. The nature of the project will also lead to closer ties and interdisciplinary work between philosophers and mathematicians.
Read moreRead less
The Cultural Impact of Irregular Marriage in the Age of British Colonialism, 1660-c.1860. Marriage has always been central to our understanding of relations between literature, society and culture. This project significantly revises that understanding by focussing on the irregular marriage practices which thrived in Britain and its colonies from 1660 to c.1860. It demonstrates, for instance, how the novel genre became respectable partly by marginalising irregular marriages; how Gretna Green we ....The Cultural Impact of Irregular Marriage in the Age of British Colonialism, 1660-c.1860. Marriage has always been central to our understanding of relations between literature, society and culture. This project significantly revises that understanding by focussing on the irregular marriage practices which thrived in Britain and its colonies from 1660 to c.1860. It demonstrates, for instance, how the novel genre became respectable partly by marginalising irregular marriages; how Gretna Green weddings came to typify modern romance in drama and fiction; and how marriage regulations underpinned literary portrayals of civil society in the Australian penal colony. It will deliver a groundbreaking monograph which accounts for marriage's role in modern literary culture in new terms.Read moreRead less