Many Ys in monotremes: multiple sex chromosomes and sex determination in platypus and echidna. Platypus and Echidna are Australian icons, even featuring on our coins. Their unusual biology and ancient relationship to humans make them unique for understanding the mammalian genome, as demonstrated by our recent discovery of ten sex chromosomes in platypus that link mammal and bird sex. Still little is known about their genome, embryo development and how sex is determined. We will identify new gene ....Many Ys in monotremes: multiple sex chromosomes and sex determination in platypus and echidna. Platypus and Echidna are Australian icons, even featuring on our coins. Their unusual biology and ancient relationship to humans make them unique for understanding the mammalian genome, as demonstrated by our recent discovery of ten sex chromosomes in platypus that link mammal and bird sex. Still little is known about their genome, embryo development and how sex is determined. We will identify new genes on all ten sex chromosomes and investigate how they determine sex. The set up of an Australian Monotreme Resource Centre will be crucial for this research and attract worldwide high profile collaborations. We will answer important general questions in monotreme biology and contribute to our understanding of sexual abnormalities in humans.Read moreRead less
Discovering mechanisms of primary embryonic tissue migration through live cell imaging and novel genetic approaches. The studies proposed here will provide concepts and knowledge about the molecular basis of cell migration that will impact on diverse aspects of human health, such as the causes and nature of tumour metastasis and our understanding of the developmental basis of birth defects. In addition, understanding cell migration mechanisms will allow us to better predict or control the behav ....Discovering mechanisms of primary embryonic tissue migration through live cell imaging and novel genetic approaches. The studies proposed here will provide concepts and knowledge about the molecular basis of cell migration that will impact on diverse aspects of human health, such as the causes and nature of tumour metastasis and our understanding of the developmental basis of birth defects. In addition, understanding cell migration mechanisms will allow us to better predict or control the behaviour of therapeutic stem cells introduced into the body.Read moreRead less
Genome-wide discovery of translation control mechanisms. This project aims to reveal currently unknown molecular details of protein synthesis, a step of gene expression that is central to all of life. To achieve this, innovative methods based on next-generation sequencing will be deployed in the yeast model organism. Yeasts are of importance as pathogens as well as in the food and biotechnology industry sector. Thus, new knowledge generated in this project will help solve problems of invasive pa ....Genome-wide discovery of translation control mechanisms. This project aims to reveal currently unknown molecular details of protein synthesis, a step of gene expression that is central to all of life. To achieve this, innovative methods based on next-generation sequencing will be deployed in the yeast model organism. Yeasts are of importance as pathogens as well as in the food and biotechnology industry sector. Thus, new knowledge generated in this project will help solve problems of invasive pathogenic behaviour and biomass production.Read moreRead less
Tracking factor footprints to reveal the intricacy and control of translation initiation. Messenger ribonucleic acid (RNA) translation is required for all of life and knowledge of how it works is central to modern life sciences. This project will develop novel ways of studying translation, generating entirely new descriptions of its inner workings that may transform knowledge of gene function and its use in medical and biotechnological processes.
Discovery Early Career Researcher Award - Grant ID: DE170100443
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
Landscape genomics to make an endangered community resilient. This project aims to use landscape genomic techniques to assess how key species of the critically endangered Box-Gum Grassy Woodland community migrate and adapt under changing environmental conditions. Changing climate and land use threaten ecological communities, and alter environments at alarming rates. When species are pushed beyond their environmental tolerances, they will migrate, adapt or face local extinction. This alteration o ....Landscape genomics to make an endangered community resilient. This project aims to use landscape genomic techniques to assess how key species of the critically endangered Box-Gum Grassy Woodland community migrate and adapt under changing environmental conditions. Changing climate and land use threaten ecological communities, and alter environments at alarming rates. When species are pushed beyond their environmental tolerances, they will migrate, adapt or face local extinction. This alteration of the community structure affects the stability and function of the ecosystem. Expected outcomes include efficient use of limited conservation resources, ensuring the long term persistence of the endangered community.Read moreRead less
Genomics for persistence of Australian freshwater fish. Biodiversity faces an unpredictable cocktail of impacts and global environmental change, against which the best insurance is genetic diversity. We will develop genomic measures of ecological-genetic functions and evolutionary potential for managing Australian freshwater fish.
Understanding “reinforcement”, an evolutionary process that can lead to the origin of new species and generate species diversity. Understanding how species are formed is of broad significance. National benefit will come from internationally competitive research and collaborations with leading international researchers. Benefits will also come under the ARC Priority Goals of 'An Environmentally Sustainable Australia' as I will (i) provide genetic data that will be invaluable for the conservation ....Understanding “reinforcement”, an evolutionary process that can lead to the origin of new species and generate species diversity. Understanding how species are formed is of broad significance. National benefit will come from internationally competitive research and collaborations with leading international researchers. Benefits will also come under the ARC Priority Goals of 'An Environmentally Sustainable Australia' as I will (i) provide genetic data that will be invaluable for the conservation of a highly threatened species, (ii) determine the importance of contact zones for generating new species and maintaining the evolutionary potential of regions, and (iii) address the role of climate change in shaping diversity over recent evolutionary time, an understanding of which is essential for predicting the impact of future change. Read moreRead less
How does ecological disturbance shape the genetic diversity of natural populations? Environmental disturbances shape the dynamics of the world's ecosystems. However, we do not understand how they influence biodiversity at its most fundamental level, genetic diversity. This is important, because genetic diversity affects the fitness of individuals, the viability of populations and the adaptability of species. This project will study fire in the Australian environment to discover how disturbance a ....How does ecological disturbance shape the genetic diversity of natural populations? Environmental disturbances shape the dynamics of the world's ecosystems. However, we do not understand how they influence biodiversity at its most fundamental level, genetic diversity. This is important, because genetic diversity affects the fitness of individuals, the viability of populations and the adaptability of species. This project will study fire in the Australian environment to discover how disturbance affects genetic diversity. By integrating landscape genomics and computational modelling with long-term field studies, the research will significantly advance our understanding of how genetic diversity is distributed, and improve our ability to predict the responses of natural populations to changes in the frequency and severity of wildfire.Read moreRead less
Metapopulation and habitat quality: towards an integrated approach to the conservation of an endangered grassland lizard. Our research will provide the basis upon which the grassland earless dragon can be removed from its endangered status and provide a template for the future science based management of other endangered species. Australia will gain through this project by reducing its risk of losing yet another species through inappropriate management.
Optimising plant populations for ecological restoration and resilience. When choosing individual plants for restoration populations, there is potentially a trade-off between maximising genetic diversity (‘adaptability’) and selection for desirable properties (‘adaptation’). This project aims to develop pioneering methods to quantify this trade-off, and facilitate the design of optimised populations, with a focus on two Australian rainforest trees that are being impacted by myrtle rust infection: ....Optimising plant populations for ecological restoration and resilience. When choosing individual plants for restoration populations, there is potentially a trade-off between maximising genetic diversity (‘adaptability’) and selection for desirable properties (‘adaptation’). This project aims to develop pioneering methods to quantify this trade-off, and facilitate the design of optimised populations, with a focus on two Australian rainforest trees that are being impacted by myrtle rust infection: Rhodamnia argentea and Rhodamnia rubescens. By studying the genetic variation in each species, and how this relates to myrtle rust resistance and climate, this project aims to design populations that are genetically diverse, maximally resistant to myrtle rust, and adapted to future climate.Read moreRead less