Discovering mechanisms of primary embryonic tissue migration through live cell imaging and novel genetic approaches. The studies proposed here will provide concepts and knowledge about the molecular basis of cell migration that will impact on diverse aspects of human health, such as the causes and nature of tumour metastasis and our understanding of the developmental basis of birth defects. In addition, understanding cell migration mechanisms will allow us to better predict or control the behav ....Discovering mechanisms of primary embryonic tissue migration through live cell imaging and novel genetic approaches. The studies proposed here will provide concepts and knowledge about the molecular basis of cell migration that will impact on diverse aspects of human health, such as the causes and nature of tumour metastasis and our understanding of the developmental basis of birth defects. In addition, understanding cell migration mechanisms will allow us to better predict or control the behaviour of therapeutic stem cells introduced into the body.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561229
Funder
Australian Research Council
Funding Amount
$518,427.00
Summary
Establishment of a Multiphoton Microscope Imaging Platform for Live Cell and Tissue, and Optical Imaging. This proposal seeks to establish a multidisciplinary multiphoton imaging laboratory, expanding the imaging capabilities of a Core Regional Imaging Facility. This Facility supports researchers across all Monash campuses and hospital-based research Schools, as well as outside research groups in the Victorian region. Furthermore, this equipment will support significant fiber optic research at V ....Establishment of a Multiphoton Microscope Imaging Platform for Live Cell and Tissue, and Optical Imaging. This proposal seeks to establish a multidisciplinary multiphoton imaging laboratory, expanding the imaging capabilities of a Core Regional Imaging Facility. This Facility supports researchers across all Monash campuses and hospital-based research Schools, as well as outside research groups in the Victorian region. Furthermore, this equipment will support significant fiber optic research at Victoria University for the development of communication and endoscopic technology. The instrument design will allow multiple use of the lightsource and choice of specific imaging devices (microscopes) to ensure that applications in biocellular imaging, intravital microscopy and fiber optic design and imaging are individually optimised.Read moreRead less
Novel bioinformatics approaches for biological inference from comparative genomics data. Unlocking the potential of the human and other genome sequences depends almost entirely upon comparative genomics techniques. We will develop powerful bioinformatic models, implemented as high-performance computing solutions, for the examination of gene sequences. Improving these models, which represent the initial building block for all comparative genomics techniques, will be beneficial across genomics dep ....Novel bioinformatics approaches for biological inference from comparative genomics data. Unlocking the potential of the human and other genome sequences depends almost entirely upon comparative genomics techniques. We will develop powerful bioinformatic models, implemented as high-performance computing solutions, for the examination of gene sequences. Improving these models, which represent the initial building block for all comparative genomics techniques, will be beneficial across genomics dependent industries. A major outcome from this work will be an integrated software/hardware product optimised for statistical examination of very large-scale genomics data.Read moreRead less
The role of gamma glutamyl cyclotransferase in glutathione homeostasis. The aim of this study is to understand the structure and function of gamma-glutamyl cyclotransferase (GGCT) and its role in glutathione synthesis and turnover. Glutathione is essential for life and serves multiple biological functions protecting against oxidative stress, and aiding in the detoxification and excretion of foreign chemicals. This study will explore a new approach to changing intracellular glutathione concentra ....The role of gamma glutamyl cyclotransferase in glutathione homeostasis. The aim of this study is to understand the structure and function of gamma-glutamyl cyclotransferase (GGCT) and its role in glutathione synthesis and turnover. Glutathione is essential for life and serves multiple biological functions protecting against oxidative stress, and aiding in the detoxification and excretion of foreign chemicals. This study will explore a new approach to changing intracellular glutathione concentrations that has wide applications in the treatment of inherited enzyme deficiencies, cancer and the development of herbicide resistant crop plants. The study will also contribute to the training of scientists for the future development of the Australian biotechnology industryRead moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453832
Funder
Australian Research Council
Funding Amount
$550,910.00
Summary
New directions in biomolecular mass spectrometry. The combined UoW/ANU mass spectrometry facility supports a range of research projects in high priority areas including proteomics, mechanisms of aging, anticancer drugs and pathogenicity. The facility has several key deficiencies: 1) the ability to study very high molecular weight biomolecular complexes, 2) the ability to study ion-molecule interactions that have implications in mechanisms of chemistry in nature, and 3) researchers at ANU lack es ....New directions in biomolecular mass spectrometry. The combined UoW/ANU mass spectrometry facility supports a range of research projects in high priority areas including proteomics, mechanisms of aging, anticancer drugs and pathogenicity. The facility has several key deficiencies: 1) the ability to study very high molecular weight biomolecular complexes, 2) the ability to study ion-molecule interactions that have implications in mechanisms of chemistry in nature, and 3) researchers at ANU lack essential walk-up access to high sensitivity protein sequence analysis (MS/MS). The placement of resources that address these deficiencies in one geographical region and collaboration between these institutions will produce a research interaction unique in Australia.Read moreRead less
Personalised Learning for Per-pixel Prediction Tasks in Image Analysis. AI-assisted image segmentation & synthesis are very challenging and usually require pixel-level labelling (per-pixel prediction) that is costly to obtain. The small amount of labels makes it difficult to train an “optimal” unified model for varied data as conventional methods did. This project aims to develop a new paradigm “personalised learning” to tackle this problem, where each image could be dealt with a model tailored ....Personalised Learning for Per-pixel Prediction Tasks in Image Analysis. AI-assisted image segmentation & synthesis are very challenging and usually require pixel-level labelling (per-pixel prediction) that is costly to obtain. The small amount of labels makes it difficult to train an “optimal” unified model for varied data as conventional methods did. This project aims to develop a new paradigm “personalised learning” to tackle this problem, where each image could be dealt with a model tailored to individual characteristics. The success of this project could significantly advance the fundamental research in image analysis. Expected outcomes include new knowledge and algorithms for image analysis, which could benefit fields like biology and archaeology, where labeled images are hard to attain and scarce.Read moreRead less
What is safe about “safe migration”? Migration management in the Mekong. The project seeks to examine the claims that new policy models make about assuring the safety of labour migrants. What is safe about safe migration? Regulation of labour migrants is a central policy concern in Asia, Australia and elsewhere. In an attempt to address anti-trafficking, several donors, United Nations agencies, nongovernment organisations and Governments have launched ‘safe migration’ programs which, rather than ....What is safe about “safe migration”? Migration management in the Mekong. The project seeks to examine the claims that new policy models make about assuring the safety of labour migrants. What is safe about safe migration? Regulation of labour migrants is a central policy concern in Asia, Australia and elsewhere. In an attempt to address anti-trafficking, several donors, United Nations agencies, nongovernment organisations and Governments have launched ‘safe migration’ programs which, rather than focusing solely on the legal status of migrants, seek to develop mechanisms (eg hotline numbers) to assure their safety. This research examines the claims of safety that this shift from anti-trafficking to safe migration has engendered, and whether and in what terms labour migrants might be consequently safer’. Project results may inform aid programs and government policies.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100122
Funder
Australian Research Council
Funding Amount
$620,000.00
Summary
Returning WA Rapid Acquisition Fluorescent Microscopy to the cutting edge. The equipment proposal aims to establish West Australia's only super-rapid-speed, high throughput confocal microscopy facility. The technology will provide researchers in biotechnology, medicine, environmental biology and agriculture with contemporary state-of-art opportunities to analyse living cells and/or large-area tissue specimens in three-dimensions with the highest possible speed and high-resolution. West Australia ....Returning WA Rapid Acquisition Fluorescent Microscopy to the cutting edge. The equipment proposal aims to establish West Australia's only super-rapid-speed, high throughput confocal microscopy facility. The technology will provide researchers in biotechnology, medicine, environmental biology and agriculture with contemporary state-of-art opportunities to analyse living cells and/or large-area tissue specimens in three-dimensions with the highest possible speed and high-resolution. West Australia hosts 1 twelve-year old historic rapid-acquisition confocal microscope that is heavily subscribed, no longer manufactured and prone to regular, prolonged, costly breakdowns. Accessing high-speed confocal systems in other states is not a viable option putting WA-based researchers at a significant disadvantage.Read moreRead less
Attracting The Next Generation - Primary Industries Education Foundation Australia Membership 2022-2023
Funder
Fisheries Research and Development Corporation
Funding Amount
$52,550.00
Summary
Engaging with and educating the next generation is challenging and competitive, given the range of opportunities available to teachers and students in terms of topics, development opportunities and careers locally, nationally and globally.
Providing awareness, access and support to educators and students is critical to attracting and retaining people across fishing and aquaculture. Through curriculum aligned resources and aligned interventions, activities and experiences, FRDC can spar ....Engaging with and educating the next generation is challenging and competitive, given the range of opportunities available to teachers and students in terms of topics, development opportunities and careers locally, nationally and globally.
Providing awareness, access and support to educators and students is critical to attracting and retaining people across fishing and aquaculture. Through curriculum aligned resources and aligned interventions, activities and experiences, FRDC can spark the curiosity and also provide access to a range of people in fishing and aquaculture through partnering with PIEFA.
This project builds on the strong relationship with PIEFA to conduct research to understand the current level of engagement, barriers and opportunities to position fishing and aquaculture with students and educators. This research will position FRDC for success through utilisation of established, trusted channels and networks. Providing opportunities to showcase the wide variety careers through interactive activities and self directed learning provides the fishing and aquaculture community a direct connection with the next generation.
PIEFA provides a mechanism to showcase fishing and aquaculture, and food and fibre more broadly in Australian schools.
This includes accessing multiple platforms, newsletters, exclusive invitations to members meetings and PIEFA AGM. Invitation to 2023 PIEFA Conference and events. Objectives: 1. Understand and improve teacher awareness, confidence and knowledge to effectively implement food and fibre education in Australian schools 2. Utilise and leverage trusted, valued PIEFA networks and channels 3. Food and fibre education resources are accessible and are accessed by a growing number of Australian schools 4. Inform and engage with a national strategic framework that supports schools awareness and delivery of food and fibre education and careers 5. Food and fibre education initiatives and messages in the wider media and industry spheres are identified and shared between PIEFA and FRDC Read moreRead less