Defining FMR1 And SNRPN Epigenetic Signatures Associated With Neurodevelopmental Disorders
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Fragile X Syndrome and imprinting disorders such as Prader-Willi Syndrome and Angelman Syndrome are characterised by variable penetrance for intellectual disability, motor delay and autism spectrum disorder. This project aims to investigate the prognostic value of using blood-based biomarker tests and sensitive neuroscience informed measures to predict risk and severity of neuropsychological problems in children affected by these disorders.
Host-virus Protein Complexes In The Immune System Response To Influenza
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
This proposal will investigate the inhibition of the human immune response by viruses. Specifically, an enzyme, TRIM25, which ubiquitinates proteins important for signalling the viral immune response has recently been shown to be inhibited by the non-structural influenza protein NS1. The mechanism of this inhibition is unknown and is thus the subject of this project.
The Natural History Of Disruptive Behaviour Disorders: Symptom Trajectory, Outcomes, And Intervention
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
This Fellowship aims to determine why some young people with disruptive behaviour disorders (attention-deficit/hyperactivity disorder and conduct disorder) have worse outcomes than others with the same disorders. This body of work will investigate how differences in symptoms and environmental factors determine their outcomes in later life. These findings will also be used to develop an intervention targeted at young at-risk Australians.
Structural Studies On The Conjugative Apparatus Of The Gram-positive Bacteria, Clostridium Perfringens.
Funder
National Health and Medical Research Council
Funding Amount
$287,321.00
Summary
Antibiotic resistance is a worldwide health problem. It has severely reduced the effectiveness of many antibiotics driving up the health care costs and death rates associated with bacterial infections. This project aims to investigate how antibiotic resistance determinants are transferred in the pathogenic bacteria, Clostridium perfringens. By understanding the mechanism of antibiotic resistance transfer in bacteria we will be better armed to combat antibiotic resistance.