Development of mock circulatory system for complex haemodynamic modelling. This project aims to develop a unique mock experimental system to study blood flow dynamics in anatomically realistic coronary artery phantoms. The field of cardiology involves complex fluid dynamic problems, which require the expertise of the fluid dynamics engineer to understand the hemodynamics. Significant innovation in manufacturing and experimental measurement methodologies will be required to develop accurate model ....Development of mock circulatory system for complex haemodynamic modelling. This project aims to develop a unique mock experimental system to study blood flow dynamics in anatomically realistic coronary artery phantoms. The field of cardiology involves complex fluid dynamic problems, which require the expertise of the fluid dynamics engineer to understand the hemodynamics. Significant innovation in manufacturing and experimental measurement methodologies will be required to develop accurate models, which will be designed to allow the partner organisation to undertake further hemodynamic research.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100085
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
Micro/Nanofluidic Characterisation Facility. Micro/nanofluidic characterisation facility: Microfluidics promises to enable diagnosis of medical diseases using devices which perform laboratory experiments but on a scale which means the entire system can be hand-held. Whilst the fabrication of miniaturised fluidic channels is well established, the challenge is to bring additional functions onto the chip reducing the reliance on external pumps and electronics. This facility will allow the character ....Micro/Nanofluidic Characterisation Facility. Micro/nanofluidic characterisation facility: Microfluidics promises to enable diagnosis of medical diseases using devices which perform laboratory experiments but on a scale which means the entire system can be hand-held. Whilst the fabrication of miniaturised fluidic channels is well established, the challenge is to bring additional functions onto the chip reducing the reliance on external pumps and electronics. This facility will allow the characterisation of technologies which address on-chip sample preparation using pulsed ultrasonic waves, filtration and pumping using nanofluidic structures, and detection using on-chip circuitry. As such the facility will have the capability to directly address the challenges which must be met to allow diagnosis in rural underprivileged areas. Read moreRead less
Acoustic single cell traps: Understanding the woods by examining the trees. This project aims to define the underlying physics behind the manipulation of individual cells in a microfluidic chip using acoustic forces. The technology investigated would offer biomedical researchers a unique capability: that of tracking individual cell responses. It is known for example that drug resistance and latency emerge from small sub-populations of cells, so crucial information is lost when cells are studied ....Acoustic single cell traps: Understanding the woods by examining the trees. This project aims to define the underlying physics behind the manipulation of individual cells in a microfluidic chip using acoustic forces. The technology investigated would offer biomedical researchers a unique capability: that of tracking individual cell responses. It is known for example that drug resistance and latency emerge from small sub-populations of cells, so crucial information is lost when cells are studied at a population level. To trap single cells, the acoustic wavelength excited must be reduced to the order of a cell diameter. By enabling the analysis of different responses due to subtle cell difference, information pertinent to infection pathways and drug response could be gathered.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100194
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
Optical diagnostics for the investigation of high-speed energetic processes. Optical diagnostics for the investigation of high-speed energetic processes:
The project seeks to establish equipment to enable the investigation of high-speed energetic processes. Such processes, where large amounts of energy are released over a short time frame, occur in nature and almost every field of science and engineering, and their investigation is a formidable challenge. This challenge is designed to be met th ....Optical diagnostics for the investigation of high-speed energetic processes. Optical diagnostics for the investigation of high-speed energetic processes:
The project seeks to establish equipment to enable the investigation of high-speed energetic processes. Such processes, where large amounts of energy are released over a short time frame, occur in nature and almost every field of science and engineering, and their investigation is a formidable challenge. This challenge is designed to be met through the combined use of state-of-the-art flow visualisation, thermography and spectrometry equipment. These diagnostics would open avenues into so far impossible or difficult to conduct research on highly transient phenomena in various research fields, which include various aspects of fluid mechanics, combustion, and fracture mechanics. The equipment would be instrumental in the design of better and innovative machines, materials, instruments and processes.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100094
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Development of a world-class facility for three dimensional dynamic testing. Development of a world-class facility for three dimensional dynamic testing: This project aims to establish a world-class facility for multi-directional dynamic testing. Currently there are no such facilities in Australia. The ability to recreate dynamic motion in all available degrees-of-freedom opens up enormous fields of research not currently possible in Australia. This includes such areas as vibration testing, mate ....Development of a world-class facility for three dimensional dynamic testing. Development of a world-class facility for three dimensional dynamic testing: This project aims to establish a world-class facility for multi-directional dynamic testing. Currently there are no such facilities in Australia. The ability to recreate dynamic motion in all available degrees-of-freedom opens up enormous fields of research not currently possible in Australia. This includes such areas as vibration testing, materials testing, biomechanics and human factors, blast and earthquake simulations, field robotics, automotive safety research, flight/vehicle simulation, and marine applications including sloshing of liquids and liquefaction of fines. In conjunction with a 3D laser doppler system this facility will be unique in the world for dynamic mechanical testing.Read moreRead less
Atomic forces for sorting ultrabright nanodiamonds. This project aims to sort fluorescent nanodiamonds according to their brightness using atomic radiation pressure. Fluorescent nanodiamonds can overcome all limitations associated with conventional fluorescent bio-labels. While readily available, their brightness varies greatly, so a method for yielding high-quality material with consistent brightness is needed. This project combines techniques from laser manipulation of cold atoms and microflui ....Atomic forces for sorting ultrabright nanodiamonds. This project aims to sort fluorescent nanodiamonds according to their brightness using atomic radiation pressure. Fluorescent nanodiamonds can overcome all limitations associated with conventional fluorescent bio-labels. While readily available, their brightness varies greatly, so a method for yielding high-quality material with consistent brightness is needed. This project combines techniques from laser manipulation of cold atoms and microfluidics to create an optofluidic method of particle separation. The proposed device could sort nanodiamonds more than a billion times faster than active sorting techniques. This is expected to lead to better tools for bio-imaging and bio-manipulation.Read moreRead less
Integrated Piezoelectric Microsystems for Actuation and Sensing. Piezoelectric transducers provide the highest positioning accuracy of any known actuator and the highest dynamic force resolution of any known sensor. However, these capabilities are limited to macro scale applications since piezoelectric materials are not compatible with integrated circuit (IC) or Micro-Electro-Mechanical Systems fabrication processes. This project aims to extend the use of piezoelectric materials to the meso- and ....Integrated Piezoelectric Microsystems for Actuation and Sensing. Piezoelectric transducers provide the highest positioning accuracy of any known actuator and the highest dynamic force resolution of any known sensor. However, these capabilities are limited to macro scale applications since piezoelectric materials are not compatible with integrated circuit (IC) or Micro-Electro-Mechanical Systems fabrication processes. This project aims to extend the use of piezoelectric materials to the meso- and micro-scale by fabricating miniature piezoelectric positioning and sensor systems. These devices will include six-axis nano-positioners and ultra-high resolution accelerometers and gyroscopes. This technology will create a new market for devices that are lower cost than macro-scale systems but provide higher performance than silicon based microsystems.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100879
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Design, modelling and advanced control of high performance nanopositioners for atomic force microscopy. A high-speed nanopositioner with nanoscale manoeuvring accuracy is used extensively in nanotechnology applications such as biological cell studies and nanomanipulation. This project seeks to address fundamental problems associated with the design and control of nanopositioners, which will subsequently benefit Australian nanotechnology research.