Development of mock circulatory system for complex haemodynamic modelling. This project aims to develop a unique mock experimental system to study blood flow dynamics in anatomically realistic coronary artery phantoms. The field of cardiology involves complex fluid dynamic problems, which require the expertise of the fluid dynamics engineer to understand the hemodynamics. Significant innovation in manufacturing and experimental measurement methodologies will be required to develop accurate model ....Development of mock circulatory system for complex haemodynamic modelling. This project aims to develop a unique mock experimental system to study blood flow dynamics in anatomically realistic coronary artery phantoms. The field of cardiology involves complex fluid dynamic problems, which require the expertise of the fluid dynamics engineer to understand the hemodynamics. Significant innovation in manufacturing and experimental measurement methodologies will be required to develop accurate models, which will be designed to allow the partner organisation to undertake further hemodynamic research.Read moreRead less
Integrin Activation by Fluid Flow Disturbance: Mechanobiology Approaches. Understanding how cells can sense and respond to mechanical environment such as dynamic blood flow represents a fundamental question in the emerging field of mechanobiology. This project develops new biomechanical engineering approaches to determine the critical interrelationships among fluid flow disturbance, platelet clotting and the mechano-sensitive signal transduction mechanisms of integrin receptor – the most importa ....Integrin Activation by Fluid Flow Disturbance: Mechanobiology Approaches. Understanding how cells can sense and respond to mechanical environment such as dynamic blood flow represents a fundamental question in the emerging field of mechanobiology. This project develops new biomechanical engineering approaches to determine the critical interrelationships among fluid flow disturbance, platelet clotting and the mechano-sensitive signal transduction mechanisms of integrin receptor – the most important mechano-sensor implicated in cell adhesion, migration, growth and survival. Specifically, it integrates nationally unique cutting-edge techniques including single-molecule force probe, microparticle image velocimetry, microfluidics and molecular dynamics simulation, super resolution and 3D volumetric imaging modalities.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100194
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
Optical diagnostics for the investigation of high-speed energetic processes. Optical diagnostics for the investigation of high-speed energetic processes:
The project seeks to establish equipment to enable the investigation of high-speed energetic processes. Such processes, where large amounts of energy are released over a short time frame, occur in nature and almost every field of science and engineering, and their investigation is a formidable challenge. This challenge is designed to be met th ....Optical diagnostics for the investigation of high-speed energetic processes. Optical diagnostics for the investigation of high-speed energetic processes:
The project seeks to establish equipment to enable the investigation of high-speed energetic processes. Such processes, where large amounts of energy are released over a short time frame, occur in nature and almost every field of science and engineering, and their investigation is a formidable challenge. This challenge is designed to be met through the combined use of state-of-the-art flow visualisation, thermography and spectrometry equipment. These diagnostics would open avenues into so far impossible or difficult to conduct research on highly transient phenomena in various research fields, which include various aspects of fluid mechanics, combustion, and fracture mechanics. The equipment would be instrumental in the design of better and innovative machines, materials, instruments and processes.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100507
Funder
Australian Research Council
Funding Amount
$444,471.00
Summary
Integrated active microcantilevers for high-throughput nanometrology. This project aims to develop a new versatile, high-performance microsensor platform and microscopy method for measuring nano-scale structures. The proposed microscopy tool is expected to significantly increase imaging speed and miniaturize system footprint, thereby enabling high-throughput quality control of semiconductor devices. The expected outcome is a highly-scalable and low-cost imaging system that will close the technol ....Integrated active microcantilevers for high-throughput nanometrology. This project aims to develop a new versatile, high-performance microsensor platform and microscopy method for measuring nano-scale structures. The proposed microscopy tool is expected to significantly increase imaging speed and miniaturize system footprint, thereby enabling high-throughput quality control of semiconductor devices. The expected outcome is a highly-scalable and low-cost imaging system that will close the technology gap between fabrication and inspection at the nanoscale. The benefits to Australia should include the potential for commercialization to develop this next-generation microscopy tool in high-value market sectors.Read moreRead less
Atomic forces for sorting ultrabright nanodiamonds. This project aims to sort fluorescent nanodiamonds according to their brightness using atomic radiation pressure. Fluorescent nanodiamonds can overcome all limitations associated with conventional fluorescent bio-labels. While readily available, their brightness varies greatly, so a method for yielding high-quality material with consistent brightness is needed. This project combines techniques from laser manipulation of cold atoms and microflui ....Atomic forces for sorting ultrabright nanodiamonds. This project aims to sort fluorescent nanodiamonds according to their brightness using atomic radiation pressure. Fluorescent nanodiamonds can overcome all limitations associated with conventional fluorescent bio-labels. While readily available, their brightness varies greatly, so a method for yielding high-quality material with consistent brightness is needed. This project combines techniques from laser manipulation of cold atoms and microfluidics to create an optofluidic method of particle separation. The proposed device could sort nanodiamonds more than a billion times faster than active sorting techniques. This is expected to lead to better tools for bio-imaging and bio-manipulation.Read moreRead less
Integrated Piezoelectric Microsystems for Actuation and Sensing. Piezoelectric transducers provide the highest positioning accuracy of any known actuator and the highest dynamic force resolution of any known sensor. However, these capabilities are limited to macro scale applications since piezoelectric materials are not compatible with integrated circuit (IC) or Micro-Electro-Mechanical Systems fabrication processes. This project aims to extend the use of piezoelectric materials to the meso- and ....Integrated Piezoelectric Microsystems for Actuation and Sensing. Piezoelectric transducers provide the highest positioning accuracy of any known actuator and the highest dynamic force resolution of any known sensor. However, these capabilities are limited to macro scale applications since piezoelectric materials are not compatible with integrated circuit (IC) or Micro-Electro-Mechanical Systems fabrication processes. This project aims to extend the use of piezoelectric materials to the meso- and micro-scale by fabricating miniature piezoelectric positioning and sensor systems. These devices will include six-axis nano-positioners and ultra-high resolution accelerometers and gyroscopes. This technology will create a new market for devices that are lower cost than macro-scale systems but provide higher performance than silicon based microsystems.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100879
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Design, modelling and advanced control of high performance nanopositioners for atomic force microscopy. A high-speed nanopositioner with nanoscale manoeuvring accuracy is used extensively in nanotechnology applications such as biological cell studies and nanomanipulation. This project seeks to address fundamental problems associated with the design and control of nanopositioners, which will subsequently benefit Australian nanotechnology research.