Optimizing blood flow in stented arteries: a fluid mechanics approach incorporating optical coherence tomography. Constriction in coronary arterial blood flow is a leading cause of death in Australia. Insertion of stents can rectify this problem but potentially lead to further complications. This project will use medical imaging data to construct computer models to study blood flow and particle motions in coronary arteries and improve stent designs.
Optimising haemodynamics in complex stented arteries. This project aims to optimise the hemodynamics (blood flow) in coronary arteries with high curvatures and bifurcations. Experience has shown that the build-up of plaque — and the resulting occlusion of blood flow — tends to occur in these complex arterial regions. The most common therapeutic strategy is the insertion of a stent to prop open the artery. However, the nature of the geometry often leads to post-stenting complications such as rest ....Optimising haemodynamics in complex stented arteries. This project aims to optimise the hemodynamics (blood flow) in coronary arteries with high curvatures and bifurcations. Experience has shown that the build-up of plaque — and the resulting occlusion of blood flow — tends to occur in these complex arterial regions. The most common therapeutic strategy is the insertion of a stent to prop open the artery. However, the nature of the geometry often leads to post-stenting complications such as restenosis and thrombosis, ultimately resulting in negative outcomes. In this project, advanced research methods from fluid dynamics and optimisation and control will be used to potentially minimise these highly undesirable effects.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160101098
Funder
Australian Research Council
Funding Amount
$315,000.00
Summary
Novel modelling of fluid-structure interactions in biological flows. The objective of this project is to develop a novel method to model fluid-structure interactions and turbulence in cardiovascular systems. The cardiovascular system is essential in providing nutrient and waste transport throughout the body. Because blood vessels and red blood cells are flexible, they are subjected to large deformations with significant effects on physiological functions such as blood distribution and oxygen rel ....Novel modelling of fluid-structure interactions in biological flows. The objective of this project is to develop a novel method to model fluid-structure interactions and turbulence in cardiovascular systems. The cardiovascular system is essential in providing nutrient and waste transport throughout the body. Because blood vessels and red blood cells are flexible, they are subjected to large deformations with significant effects on physiological functions such as blood distribution and oxygen release. Fluid-structure interactions are critical for understanding the intricacies of such systems but it is still a challenge to model these systems realistically using numerical methods. Expected outcomes of the project include better simulations of three-dimensional fluid-structure interactions and improved understanding of the behaviours of biological systems.Read moreRead less
Biotransport design for engineering microenvironment in scaffolds. Tissue engineering signifies an exciting opportunity to solve shortage of transplantable tissues. This project targets a critical issue in engineering thick tissue and aims to introduce computational structural optimisation to biotransport problems. The optimal scaffold is expected to create a more desirable microenvironment for better tissue growth.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100166
Funder
Australian Research Council
Funding Amount
$637,800.00
Summary
Four-dimensional coherent imaging velocimetry facility for fluid mechanics research. This project aims to enhance understanding of multi-scale fluid flows in engineering, geophysics and biomedicine by delivering a facility for high temporal and spatial resolution, three-dimensional velocity measurements. The four-dimensional, coherent imaging velocimetry facility for fluid mechanics research is aimed at addressing limitations of commercially available imaging systems. It is expected to provide ....Four-dimensional coherent imaging velocimetry facility for fluid mechanics research. This project aims to enhance understanding of multi-scale fluid flows in engineering, geophysics and biomedicine by delivering a facility for high temporal and spatial resolution, three-dimensional velocity measurements. The four-dimensional, coherent imaging velocimetry facility for fluid mechanics research is aimed at addressing limitations of commercially available imaging systems. It is expected to provide unprecedented measurement capabilities with significant benefit to the design, control and modelling of complex fluid flows found in many areas. Applications include the jets used for heating, cooling, mixing, and drug delivery in engineering and pharmacy to the kinematics of sperm and micro-organisms in bio-medicine, and wave-particle flows in geo-physics.Read moreRead less
Diabetic foot ulcers are a common and costly complication associated with Diabetes. Current treatments are only modestly effective in promoting healing, and in many cases amputation is necessary. Through this project we will develop a new treatment strategy that involves the combination of adult stem cells and powerful signal molecules to promote robust diabetic foot ulcer repair.
Aerodynamic interaction of bluff bodies with applications to sports aerodynamics. Numerical modelling and experiments will be combined by this project to characterise the flow and reduce drag on a set of objects in the wake of another object. The Olympic pursuit cycling team is a typical application, with small improvements leading to major competitiveness gains. Findings will also apply to Paralympic team sports, and potentially transportation.
Using Biomechanics To Prevent Injury And Treat Soft Tissue Disorders
Funder
National Health and Medical Research Council
Funding Amount
$705,501.00
Summary
In this fellowship, I will use biomechanical testing and analysis methods together with novel imaging methods to design and implement interventions to prevent injuries to children, and to improve treatment of obstructive sleep apnoea and complex disorders of the cerebrospinal fluid system.
Measurement and Prediction of Vulnerable Plaque Formation and Rupture. The major health problem of atherosclerosis, leading to large numbers of deaths from heart attacks and strokes worldwide, will be studied by a multidisciplinary team. Better understanding of how the disease evolves and its earlier detection will arise from this project, which will use synchrotron imaging and supercomputer prediction.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100085
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
Micro/Nanofluidic Characterisation Facility. Micro/nanofluidic characterisation facility: Microfluidics promises to enable diagnosis of medical diseases using devices which perform laboratory experiments but on a scale which means the entire system can be hand-held. Whilst the fabrication of miniaturised fluidic channels is well established, the challenge is to bring additional functions onto the chip reducing the reliance on external pumps and electronics. This facility will allow the character ....Micro/Nanofluidic Characterisation Facility. Micro/nanofluidic characterisation facility: Microfluidics promises to enable diagnosis of medical diseases using devices which perform laboratory experiments but on a scale which means the entire system can be hand-held. Whilst the fabrication of miniaturised fluidic channels is well established, the challenge is to bring additional functions onto the chip reducing the reliance on external pumps and electronics. This facility will allow the characterisation of technologies which address on-chip sample preparation using pulsed ultrasonic waves, filtration and pumping using nanofluidic structures, and detection using on-chip circuitry. As such the facility will have the capability to directly address the challenges which must be met to allow diagnosis in rural underprivileged areas. Read moreRead less