Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100166
Funder
Australian Research Council
Funding Amount
$637,800.00
Summary
Four-dimensional coherent imaging velocimetry facility for fluid mechanics research. This project aims to enhance understanding of multi-scale fluid flows in engineering, geophysics and biomedicine by delivering a facility for high temporal and spatial resolution, three-dimensional velocity measurements. The four-dimensional, coherent imaging velocimetry facility for fluid mechanics research is aimed at addressing limitations of commercially available imaging systems. It is expected to provide ....Four-dimensional coherent imaging velocimetry facility for fluid mechanics research. This project aims to enhance understanding of multi-scale fluid flows in engineering, geophysics and biomedicine by delivering a facility for high temporal and spatial resolution, three-dimensional velocity measurements. The four-dimensional, coherent imaging velocimetry facility for fluid mechanics research is aimed at addressing limitations of commercially available imaging systems. It is expected to provide unprecedented measurement capabilities with significant benefit to the design, control and modelling of complex fluid flows found in many areas. Applications include the jets used for heating, cooling, mixing, and drug delivery in engineering and pharmacy to the kinematics of sperm and micro-organisms in bio-medicine, and wave-particle flows in geo-physics.Read moreRead less
Predictive capability for particle capture in aquatic ecosystems. This project investigates the fundamental fluid mechanics of particle capture, whereby suspended particles contact and adhere to a solid structure. This process is examined in productive and biodiverse ecosystems (such as coral reefs and seagrass meadows) whose health, productivity and propagation are directly controlled by particle capture. Existing formulations for particle capture are valid only under highly idealised condition ....Predictive capability for particle capture in aquatic ecosystems. This project investigates the fundamental fluid mechanics of particle capture, whereby suspended particles contact and adhere to a solid structure. This process is examined in productive and biodiverse ecosystems (such as coral reefs and seagrass meadows) whose health, productivity and propagation are directly controlled by particle capture. Existing formulations for particle capture are valid only under highly idealised conditions that are grossly unrepresentative of the complexity of ecosystem flows. The goal of this project is to use a coupled computational-experimental campaign to develop predictive capability for particle capture in ecosystems, where the flow can be turbulent and/or wave-dominated and the biological structures complex.Read moreRead less
The role of internal wave-driven near-bed turbulent dynamics in coastal ocean sediment mobilisation. This project will determine the process of internal wave-driven sediment resuspension and transport in the coastal ocean. This will be achieved by using a combination of field observations and numerical modelling, at two diverse but representative Australian coastal regions where nonlinear internal waves dominate the dynamics. The study has significant application to the offshore oil and gas indu ....The role of internal wave-driven near-bed turbulent dynamics in coastal ocean sediment mobilisation. This project will determine the process of internal wave-driven sediment resuspension and transport in the coastal ocean. This will be achieved by using a combination of field observations and numerical modelling, at two diverse but representative Australian coastal regions where nonlinear internal waves dominate the dynamics. The study has significant application to the offshore oil and gas industry engineering design and operations as well as to environmental management of the coastal ocean ecosystems. This project will achieve a process understanding and create predictive tools describing sediment resuspension and transport for use by industry and marine managers.Read moreRead less
Hydrodynamics of Bubble Column Reactors. This project will study the hydrodynamics of bubble columns with the aim of optimising these reactors for offshore gas-to-liquid plants. Along with experiments using the state-of-art techniques such as the particle image velocimetry, radioactive particle tracking, electrical capacitance tomography and optical probes, computational fluid dynamics simulations will be conducted to gain a deeper insight into bubble-induced turbulence and regime transitions in ....Hydrodynamics of Bubble Column Reactors. This project will study the hydrodynamics of bubble columns with the aim of optimising these reactors for offshore gas-to-liquid plants. Along with experiments using the state-of-art techniques such as the particle image velocimetry, radioactive particle tracking, electrical capacitance tomography and optical probes, computational fluid dynamics simulations will be conducted to gain a deeper insight into bubble-induced turbulence and regime transitions in these reactors. This information will then be used to devise scale-up strategies of these complex and industrially important equipment.Read moreRead less
Physical processes in complex coastal reef environments: the dynamics of wave- and tide-dominated systems. Coastal reefs are ubiquitous features of Australia's coastline, yet the dynamics controlling water motion on reefs still remain poorly understood. This project will significantly advance our understanding of coastal processes within reef environments, thus improving predictions of the impacts of extreme storms and climate change on our coasts.
Role Of Hepatic Stellate Cell And Liver Progenitor Cell Interactions In The Regulation Of Wound Healing And Liver Regeneration
Funder
National Health and Medical Research Council
Funding Amount
$620,716.00
Summary
The liver has a remarkable capacity for regeneration following acute and chronic liver injury, however, the mechanisms which facilitate this wound healing are not understood. This project will examine the interactions between different liver cell populations, including hepatic stellate cells (liver fibroblasts) and liver progenitor cells (stem cells of the liver) and will determine which factors regulate inflammation, liver scarring and restitution of liver mass following chronic liver injury.
The phenomenology of unsteady impinging jets: fluid dynamics and heat transfer. This project comprises a definitive study of a fluid jet impacting a target surface and the effect of added fluctuations on its momentum and heat-transfer characteristics. This will deliver new scientific knowledge and underpin the development of an energy-efficient thermal-control technology for widespread use in many areas of engineering.
Transcriptional Control Of Blood Vessel Development By Sox18
Funder
National Health and Medical Research Council
Funding Amount
$468,564.00
Summary
Blood vessels play an essential role in maintaining the supply of nutrients to every organ and tissue in the body. Improper development of blood vessels in the embryo can compromise survival of the embryo, and defects in the ability of blood vessels to grow, regenerate and adapt to change during adult life can be life-threatening. The growth of new blood vessels (angiogenesis) is also an important factor in the ability of solid tumours to grow during the progression of cancer. It is therefore of ....Blood vessels play an essential role in maintaining the supply of nutrients to every organ and tissue in the body. Improper development of blood vessels in the embryo can compromise survival of the embryo, and defects in the ability of blood vessels to grow, regenerate and adapt to change during adult life can be life-threatening. The growth of new blood vessels (angiogenesis) is also an important factor in the ability of solid tumours to grow during the progression of cancer. It is therefore of fundamental importance in the health sciences to gain an understanding of how blood vessels form and regenerate. As a result of our collaborative research efforts, we have discovered a gene, Sox18, that appears to regulate blood vessel development by controlling the formation and-or behaviour of endothelial cells, which line the blood vessels and make them impermeable. Our research so far indicates that MICE WITH DEFECTS IN SOX18 DIE FROM VASCULAR DEFECTS, underlining the importance of this gene. THIS PROJECT IS CONCERNED WITH FINDING OUT HOW SOX18 WORKS - exactly what goes wrong in mice lacking this gene, whether Sox18 can influence endothelial cell behaviour in cell culture, how Sox18 comes to be active in endothelial cells, what genes are switched on by Sox18, and what genes Sox18 co-operates with in its role in endothelial cells. The answers to these questions will not only provide fundamental basic information about how blood vessels development is controlled, but also sow the seeds for possible future therapies in which blood vessel development could be stimulated (eg in wound healing) or suppressed (eg in tumour progression) through pharmaceutical intervention.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100094
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
Selective laser melting - an advanced manufacturing and physical modelling technology for the digital age. Selective laser melting is a new manufacturing technology that creates parts layer by layer directly from a computer model, eliminating the need for tooling or machining. This technology will be applied to a diverse range of research areas from producing the next generation of medical implants and devices to improving our understanding of geo-materials.
Prediction and control of fluid-structure interactions. Fluid-flows create a pressure that can deform the surface of a structure or cause it to vibrate; an extreme example is the fluttering of a flag. Flow-induced vibration of the external panels of vehicles causes damage, noise and can adversely affect performance. This project will develop a wholly new approach for the analysis of these interactions. The versatility and completeness of the approach permits a step-change in the design of panels ....Prediction and control of fluid-structure interactions. Fluid-flows create a pressure that can deform the surface of a structure or cause it to vibrate; an extreme example is the fluttering of a flag. Flow-induced vibration of the external panels of vehicles causes damage, noise and can adversely affect performance. This project will develop a wholly new approach for the analysis of these interactions. The versatility and completeness of the approach permits a step-change in the design of panels, reducing material and manufacturing costs without compromise to safety and performance - an immense benefit for the myriad engineered products or structures that feature flow over a deformable surface. Read moreRead less