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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100032
Funder
Australian Research Council
Funding Amount
$240,000.00
Summary
Ultra-high-performance liquid chromatography ion trap mass spectrometer to develop new capabilities in environmental and human toxicology. This facility will be dedicated to developing methods and analyses of environmental contaminants and by-products that are currently not well understood. Having this analytical capability will underpin leading research in environmental toxicology and chemistry, and will help to minimise environmental and human exposure to harmful contaminants.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100129
Funder
Australian Research Council
Funding Amount
$249,000.00
Summary
Microflow ultra high pressure liquid chromatography - high resolution mass spectrometry for chemical exposure monitoring. Microflow ultra high pressure liquid chromatography – high resolution mass spectrometry for chemical exposure monitoring: Identifying new chemicals of interest in environmental or biological samples is the first critical step toward understanding their impact to human and environment. A state-of-the-art microflow ultra high performance liquid chromatography high resolution ma ....Microflow ultra high pressure liquid chromatography - high resolution mass spectrometry for chemical exposure monitoring. Microflow ultra high pressure liquid chromatography – high resolution mass spectrometry for chemical exposure monitoring: Identifying new chemicals of interest in environmental or biological samples is the first critical step toward understanding their impact to human and environment. A state-of-the-art microflow ultra high performance liquid chromatography high resolution mass spectrometer is fundamental to extend our research capabilities to new environmental contaminants and environmental exposure biomarkers, as well as consumption biomarkers of new illicit drugs and their metabolites. This instrument will fill an important gap in our capacity to link health/ecological risk to unknown chemicals and will allow interdisciplinary researchers to advance work in environmental toxicology, chemistry and forensics.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100381
Funder
Australian Research Council
Funding Amount
$444,000.00
Summary
Facilitating detection of new psychoactive substances in wastewater. This project aims to develop and apply novel analytical methods for detecting new psychoactive substances (NPS) in wastewater. NPS are a dynamic, complex addition to the illicit drug market, and a persistent analytical challenge for wastewater analysis. This project expects to fill the current knowledge gap in detection and identification of these substances in wastewater. This will provide substantial benefits both to Australi ....Facilitating detection of new psychoactive substances in wastewater. This project aims to develop and apply novel analytical methods for detecting new psychoactive substances (NPS) in wastewater. NPS are a dynamic, complex addition to the illicit drug market, and a persistent analytical challenge for wastewater analysis. This project expects to fill the current knowledge gap in detection and identification of these substances in wastewater. This will provide substantial benefits both to Australia and internationally by aiding development of early warning drug monitoring systems, providing the rapid deployment of interventions to reduce drug-related harm in the local community, while facilitating law and government agencies to better direct resources.Read moreRead less
A global platform for identifying emerging chemical threats. This project aims to develop an automated early warning social network to systematically detect newly identified emerging chemical threats. Rapid identification of chemical exposures is key to managing chemical threats and associated risks. Global collaboration and sharing of archived, high-resolution mass spectrometry data through open/social platforms will revolutionise data processing and chemical threat identification. This project ....A global platform for identifying emerging chemical threats. This project aims to develop an automated early warning social network to systematically detect newly identified emerging chemical threats. Rapid identification of chemical exposures is key to managing chemical threats and associated risks. Global collaboration and sharing of archived, high-resolution mass spectrometry data through open/social platforms will revolutionise data processing and chemical threat identification. This project will result in a new and cost-effective approach for the identification, tracking and prioritisation of emerging chemical threats and address key national and global health risks. The outcomes include the first spatial and temporal distribution of new emerging chemical threats in Australia.Read moreRead less
Dimension reduction and model selection for statistically challenging data. This project aims to develop a deep theoretical understanding of the relationship between various dimension reduction and model selection methods used in statistical model building, and then use this understanding to develop new, improved methods of model building for statistically challenging data. The research will impact on both the theory and practice of statistics, and on substantive fields which collect and analyse ....Dimension reduction and model selection for statistically challenging data. This project aims to develop a deep theoretical understanding of the relationship between various dimension reduction and model selection methods used in statistical model building, and then use this understanding to develop new, improved methods of model building for statistically challenging data. The research will impact on both the theory and practice of statistics, and on substantive fields which collect and analyse these kinds of data. This will provide a significant improvement in the statistical model building in areas such as epidemiology, chemical and ecological sciences. The project is timely because of the increasing collection of large-dimensional, complex, correlated data sets in these and many other fields.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100482
Funder
Australian Research Council
Funding Amount
$364,536.00
Summary
Indoleamides as Molecular Interventions for Tuberculosis. This project aims to develop chemical probes capable of inhibiting the transport of essential mycolic acid across the cell wall of Mycobacterium tuberculosis. The emergence of resistant strains of Mycobacterium tuberculosis necessitates the identification of new, validated biological target(s) in the current control of tuberculosis. Preliminary data in this proposal demonstrate the discovery of indoleamides as a novel chemical entity. Dev ....Indoleamides as Molecular Interventions for Tuberculosis. This project aims to develop chemical probes capable of inhibiting the transport of essential mycolic acid across the cell wall of Mycobacterium tuberculosis. The emergence of resistant strains of Mycobacterium tuberculosis necessitates the identification of new, validated biological target(s) in the current control of tuberculosis. Preliminary data in this proposal demonstrate the discovery of indoleamides as a novel chemical entity. Development of these indoleamides may provide insights into a novel mechanism of action that could be targeted in combination with existing antitubercular agents.Read moreRead less
Soft nanotubes for biomedical applications. Nature employs self-assembly of small molecules to build complex materials. This project will mimic natural self-assemblies to design synthetic tubular structures on the nanoscale, and apply these nanostructures to solve problems in the fields of biology and medicine.
Advanced macromolecular engineering: novel approaches to self-directed assembly and vesicle formation. The aim of this project is to develop new approaches in nanotechnology for the preparation of well-defined polymeric particles. The research will result in the development of new methodology which has the potential to impact areas of commercial interest including those in the health-care sector.
The roles of metal complexes and related metalloproteins in the essential and therapeutic control of diabetes. Metal supplements, such as chromium, are consumed widely for purported fat reduction and anti-diabetic activities but pose potential efficacy, safety and essentiality, problems. This project will provide fundamental insights into how they exert their anti-diabetic effects and can be made safer and/or more efficacious for the treatment of type 2 diabetes.
Selectivity enhancement in separation science using responsive materials. Increasing public demand for quality products from the chemical, pharmaceutical, biotechnology and food industries requires access to innovative methods of chemical analysis. This project will establish a new class of separation materials of enhanced selectivity and resolving power for the fast, sensitive and reliable analysis of these products.