Mothers' History Of Mental Health Impairment And Its Impact During Mid-Life
Funder
National Health and Medical Research Council
Funding Amount
$421,580.00
Summary
There have been few specific studies of the health of women in mid-life. In mid-life, mental health impairment and health problems associated with biological and social transitions (e.g. menopause) are major concerns. National estimates indicate that between 15% and 20% of women in the mid-life age range have experienced a mental illness in the past year. The proportion of women experiencing a combination of emotional and physical symptoms, frequently associated with the menopause, is likely to ....There have been few specific studies of the health of women in mid-life. In mid-life, mental health impairment and health problems associated with biological and social transitions (e.g. menopause) are major concerns. National estimates indicate that between 15% and 20% of women in the mid-life age range have experienced a mental illness in the past year. The proportion of women experiencing a combination of emotional and physical symptoms, frequently associated with the menopause, is likely to be somewhat higher. This proposal involves merging information collected initially from 1981 onwards, with data on the mother's mental and physical health, to be collected in this follow-up. Women in this study (8556) were enrolled at their first obstetrical visit and they have been followed up shortly after the birth, when the child was 6 months, 5 years and 14 years. On each occasion extensive information has been obtained on the mother's mental and physical health, as well as on the child's health and development. This study will examine the chronicity of the mother's mental health symptoms over a 21-year period, and assess the association between her early mental health, the child's health and her current health status. This is the only large Australian cohort study to have followed a sample of women for 21 years. It will permit us to understand more of how women's health changes over time and the factors associated with these changes. It will provide the first large-scale study of factors influencing women's health transition through the menopause.Read moreRead less
A Brief Couple-focused Psycho-educational Intervention To Prevent Postnatal Mental Health Problems In Women: A Cluster Randomised Trial
Funder
National Health and Medical Research Council
Funding Amount
$99,654.00
Summary
Mental health problems in women after childbirth are of national concern. Interventions to prevent these have had little success. What Were We Thinking (WWWT) is a promising new program for mothers, fathers and newborns. It provides knowledge and skills about soothing and settling babies and enhancing parents’ understanding of their changed needs and how to share the workload fairly. This trial will test whether WWWT improves women’s mental health in the first six months of motherhood
Australia has an ageing population and women spend around one third of their lives after menopause. Optimising physical and emotional health at menopause is a national health priority, and improving the health of women will improve health for the community. This research program is targeted at improving physical and mental health for midlife and older women. Findings will be translated into changes in policy and practice which improve the lives of women in Australia and worldwide
Estrogen - A Potential New Treatment For Women & Men With Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$227,545.00
Summary
Estrogen - the major female hormone, has been shown in animal studies to decrease the two main brain chemicals (dopamine and serotonin) that are implicated in causing schizophrenia. The effect of estrogen in the brain is similar to current antipsychotic drugs. We have carried out a study that showed that when we gave 12 young women with schizophrenia 100 micrograms of estrogen in a skin patch form plus standard antipsychotic drug treament they recovered more quickly than 12 young women who recei ....Estrogen - the major female hormone, has been shown in animal studies to decrease the two main brain chemicals (dopamine and serotonin) that are implicated in causing schizophrenia. The effect of estrogen in the brain is similar to current antipsychotic drugs. We have carried out a study that showed that when we gave 12 young women with schizophrenia 100 micrograms of estrogen in a skin patch form plus standard antipsychotic drug treament they recovered more quickly than 12 young women who received standard antipsychotic drug treatment only. 100mcg is a safe dose of estrogen. In this proposal we want to expand and clarify the pilot study resutls by conducting a 28 day trial in a total of 60 women with schizophrenia. 30 women would receive 100 mcg skin patch estrogen plus antipsychotic medication and 30 women would receive antipsychotic medicationly only. We also tested the value of adding a very small dose of oral estrogen to antipsychotic drug treatment in five men with schizophrenia and found that they made a better recovery compared to five men who received standard antipsychotic drugs only. We trialled the use of estrogen for seven days in men, but this may not have been long enough to examine the real impact of estrogen treatment in men. In this proposal we want to conduct a 14 day trial in a total of 60 men with schizophrenia. 30 men would receive 2mg of oral estrogen plus antipsychotic drug treatment and their results would be compared with 30 men who received standard antipsychotic drug treatment plus a placebo tablet identical in appearance to estrogen. For 14 days, this low dose of estrogen is very safe. Potentially estrogen may be a useful addition to the current standard treatment of schizophrenia. It may decrease the duration of acute illness and in women it may have a role in preventing relapses of schizophrenia as well as improving the general health of women with schizophrenia.Read moreRead less
My research focus is the physical and mental health of Australian women at midlife. Over the next 5 years I will address the management of severe menopausal symptoms, midlife depression and the neglected health needs of women during and after cancer treatment, organ transplant and severe persistent mental illness. I will also investigate novel treatment approaches for menopausal symptoms. I will work closely with relevant professional and community groups in planning, implementation and translat ....My research focus is the physical and mental health of Australian women at midlife. Over the next 5 years I will address the management of severe menopausal symptoms, midlife depression and the neglected health needs of women during and after cancer treatment, organ transplant and severe persistent mental illness. I will also investigate novel treatment approaches for menopausal symptoms. I will work closely with relevant professional and community groups in planning, implementation and translation to ensure my research addresses their needs.Read moreRead less
HARMONY: A Cluster Randomised Controlled Trial Of A Whole Of General Practice Intervention To Prevent And Reduce Domestic Violence Among Migrant And Refugee Communities
Funder
National Health and Medical Research Council
Funding Amount
$595,289.00
Summary
Migrant and refugee victims of domestic violence (DV) are at grave risk of harm and murder and under-identified in primary care. The Harmony partnership builds on evidence-based models of DV response, to trial an innovative intervention of culturally competent and safe care in general practices with significant numbers of migrant patients. Harmony will result in data platforms that enhance assessment and care plans for DV victims, and safer outcomes for those from vulnerable populations.
Selective Estrogen Receptor Modulators (SERMs) - A Potential New Treatment For Women Of Child-bearing Age With Psychotic Symptoms Of Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$210,480.00
Summary
Schizophrenia is a devastating illness urgently requiring a new treatment approach. We have discovered that estrogen is an effective treatment for women with schizophrenia and are currently trialling a safer Selective Estrogen Receptor Modulator (SERM) known as brain estrogen� in postmenopausal women with schizophrenia. Regulatory permission is now available to trial the SERM in younger women, and we seek to extend our current SERM study into child bearing age women with schizophrenia.
Discovery Early Career Researcher Award - Grant ID: DE210100391
Funder
Australian Research Council
Funding Amount
$418,228.00
Summary
Reducing Gendered Harm in Involuntary Mental Health Service Provision. Involuntary mental health treatment is often traumatising, with women reporting additional gendered dimensions of harm. Using an action research framework that draws upon the voices of service users, families and professionals, this study aims to develop improved strategies for responding to acute mental distress in women, with a focus on reducing coercion. Expected outcomes include enhanced understandings of the experiences ....Reducing Gendered Harm in Involuntary Mental Health Service Provision. Involuntary mental health treatment is often traumatising, with women reporting additional gendered dimensions of harm. Using an action research framework that draws upon the voices of service users, families and professionals, this study aims to develop improved strategies for responding to acute mental distress in women, with a focus on reducing coercion. Expected outcomes include enhanced understandings of the experiences and impacts of compulsory mental health treatment on women and a co-designed online resource that will support the development of effective, realistic and non-coercive practices in frontline mental healthcare. The project will provide substantial benefits to mental health reform at a national and international level.Read moreRead less