FETAL BRAIN INJURY RESULTING FROM INTRAUTERINE INFECTION: LONG TERM CONSEQUENCES AND THE POTENTIAL FOR INTERVENTION
Funder
National Health and Medical Research Council
Funding Amount
$452,640.00
Summary
Brain damage during fetal life is a significant cause of later neurological problems such as cerebral palsy. Recent studies have shown that brain injury detected in infants is usually caused by adverse conditions within the uterus prior to labour, but the exact causes are poorly understood. It is also apparent that babies born prematurely are at increased risk of suffering serious brain damage. Unfortunately, at present, it is not possible to prevent or effectively treat brain damage in the fetu ....Brain damage during fetal life is a significant cause of later neurological problems such as cerebral palsy. Recent studies have shown that brain injury detected in infants is usually caused by adverse conditions within the uterus prior to labour, but the exact causes are poorly understood. It is also apparent that babies born prematurely are at increased risk of suffering serious brain damage. Unfortunately, at present, it is not possible to prevent or effectively treat brain damage in the fetus or newborn, partly due to ignorance about how and when the damage is occurring. In recent years it has become evident that infections in the mother, may be linked to both premature birth and brain damage. It has been proposed that the certain chemicals (cytokines) which are released during an infection can across the placenta to the fetus, causing inflammatory changes that lead to brain damage. However, although associations have been shown in studies of women, there is little evidence that infections actually cause brain damage in the fetus. This project will define the effects of an inflammation inducing chemical (bacterial endotoxin) on the fetal brain and the pattern of inflammation it sets up in the fetus. We will also examine the effects of brain damage caused by endotoxin in the newborn lamb, and relate this to alterations in behaviour. Once we have defined the effects of endotoxin on brain structure, we will test the effects of chemicals that are known to block the actions of inflammatory cytokines. We hope that by blocking the chemical pathway that leads to the production of harmful cytokines we may be able to prevent brain injury from occurring when the fetus is exposed to an infection in the mother. It is expected that this project will provide important information that helps us to understand how infection in the mother can cause brain injury in the fetus. This information is vital if strategies to prevent or treat brain injury are to be developed.Read moreRead less
Preventing Prenatal Brain Injury In Fetal Growth Restriction
Funder
National Health and Medical Research Council
Funding Amount
$511,294.00
Summary
Intrauterine fetal growth restriction (IUGR) is a serious complication of pregnancy associated with increased perinatal morbidity and mortality. In particular, IUGR infants have a high risk of perinatal brain injury which is likely to arise from damage before birth. Our aim is to use an ovine model of IUGR to define the causes of that brain injury and to develop new therapies that could be offered to women to protect their unborn baby.
RISK AND PROTECTION FACTORS FOR NORMAL AND ABNORMAL BRAIN AGEING: A LONGITUDINAL EPIDEMIOLOGICAL MRI STUDY
Funder
National Health and Medical Research Council
Funding Amount
$153,020.00
Summary
Brain is considered the last frontier of medicine, and ageing the major challenge to health care in the 21st century. In this proposal, we bring these two challenges together in a major new longitudinal study of ageing in Canberra that has recently been initiated. This is a longitudinal study of a random community sample covering 3 age groups - 20-24 years, 40-44 years and 60-64 years, with at least 2000 participants in each age group - who are being assessed in 1999-2001, and will be followed u ....Brain is considered the last frontier of medicine, and ageing the major challenge to health care in the 21st century. In this proposal, we bring these two challenges together in a major new longitudinal study of ageing in Canberra that has recently been initiated. This is a longitudinal study of a random community sample covering 3 age groups - 20-24 years, 40-44 years and 60-64 years, with at least 2000 participants in each age group - who are being assessed in 1999-2001, and will be followed up at 4-yearly intervals for 20 years. The focus of the study is on neuropsychiatric disorders (anxiety, depression, substance use and cognitive disorders). In this application, we propose to perform MRI scans and blood tests on a quarter (n-500) of the 60-64 sample to obtain an epidemiological sample for brain morphology. Not only will we be able to study changes in brain morphology over time, and relate it with cognitive function and psychiatric disorder, we will also be able to assess the role of risk and protection factors. We are particularly interested in brain reserve, dietary factors (anti-oxidants, omega 3, wine and folate) and drugs (anti-inflammatory drugs, hormone replacement and vitamin supplements) as protection factors, and hypertension, homocysteine levels, white matter lesions on MRI and low hippocampal volumes as risk factors for cognitive impairment and dementia. We also want to study the brain morphological correlates of Depression in a community sample. The study will enhance our understanding of the ageing brain, both in health and disease, and identify factors that increase or decrease the risk of cognitive impairment and psychiatric disorder in old age.Read moreRead less
Cerebrovascular Effects Of Intrauterine Hypoxia: Contribution To Perinatal Brain Injury
Funder
National Health and Medical Research Council
Funding Amount
$579,138.00
Summary
During pregnancy, delivery of oxygen and nutrients to the growing fetus is sometimes disturbed, and can lead to injury of the developing brain. In this project we investigate the idea that low oxygen (hypoxia) causes brain demage to blood vessels in the fetal brain, and new blood vessesl produced in an attempt to repair this damage are fragile and prone to rupture, explaining the high incidence of bleeding in the brain of prematurely-born and full term infants that experience birth hypoxia.
Understanding White Spot Syndrome Virus (WSSV) Transmission In Moreton Bay - Epidemiological Modelling Of Surveillance Data
Funder
Fisheries Research and Development Corporation
Funding Amount
$135,000.00
Summary
On the basis of Biosecurity Queensland (BQ) surveillance April 2020 which detected 112 mangrove crabs positive to white spot syndrome virus (WSSV), and their confirmation just a few weeks later that two farms on the Logan River had samples testing positive for WSSV, APFA Management Committee identified a need for a qualified epidemiologist to undertake comprehensive modelling to: 1) Identify what vectors/sentinels are involved in the spread of WSSV and design surveillance for these 2) In ....On the basis of Biosecurity Queensland (BQ) surveillance April 2020 which detected 112 mangrove crabs positive to white spot syndrome virus (WSSV), and their confirmation just a few weeks later that two farms on the Logan River had samples testing positive for WSSV, APFA Management Committee identified a need for a qualified epidemiologist to undertake comprehensive modelling to: 1) Identify what vectors/sentinels are involved in the spread of WSSV and design surveillance for these 2) Investigate at what rate WSSV is spreading by defining the current zone 3) Understand how seasonal factors could impact the spread 4) Advise whether the boundary of the current zone is likely to be changed.
There is significant surveillance data available from several studies and several years of surveillance. This data has not undergone extensive, systematic and comprehensive analysis to determine risk factors, spread etc. There is information suggesting that sentinel vectors carrying WSSV can change year to year and it is important to predict what vectors will be involved in spreading WSSV in the future to ensure appropriate biosecurity measures and monitoring can take place. Clear independent epidemiological advice around the potential sources and likely spread is needed. Working out which animals form proper sentinels is important and will not only describe how WSSV moves around in the environment, what the zones look like, but also how to target mitigation measures.
This information will assist the prawn farming industry initiate appropriate management practices on an enterprise and regional level and to improve their biosecurity plans and potentially inform industry and policy makers on the benefits of a regional or zone-based management plan. Understanding whether WSSV remained within the environment at low prevalence for 2017-2020, or whether there was a separate incursion in 2020 is beneficial because the management protocol will be different in each scenario. In addition, understanding of risk factors will assist predictions about where and if this virus is most likely to spread? Objectives: 1. Identify vectors/sentinels involved in the spread of WSSV, designing surveillance for these. 2. Investigate the rate at which WSSV is spreading by defining the current zone. 3. Understand how seasonal factors (e.g. rainfalls, temperature changes) impact the spread of WSSV. 4. Advise whether the boundary of the current zone is likely to change geographically and if so, establish the likely rate of movement in time based on current indicators. 5. Examine other risk factors for disease transmission and spread Read moreRead less
The WSD outbreak and subsequent significant mortality events is a massive threat to the prawn aquaculture industry throughout Australia. WSD is an exotic disease, resulting in the emergency animal disease provisions being implemented by State and Commonwealth governments. The response so far is to attempt to eradicate the disease by destruction of diseased stock and implementation of quarantine arrangements. This has resulted in the loss of millions of dollars to the prawn farming industry. In ....The WSD outbreak and subsequent significant mortality events is a massive threat to the prawn aquaculture industry throughout Australia. WSD is an exotic disease, resulting in the emergency animal disease provisions being implemented by State and Commonwealth governments. The response so far is to attempt to eradicate the disease by destruction of diseased stock and implementation of quarantine arrangements. This has resulted in the loss of millions of dollars to the prawn farming industry. In addition to the prawn farmers, other industries affected include wild prawns, crabs and recreational fishers.
A coordinated response from the Australian prawn farming industry is needed to ensure Federal and State stakeholders will have the confidence to provide targeted assistance and to ensure that that efforts by all stakeholders are not duplicated and / or contradictory.
Objectives: 1. Deliver a Prawn Industry WSD Response Plan covering actions that can be implemented on individual farms by the whole of industry and government. 2. To prepare a plan for the prawn farming industry and its stakeholders to respond to WSD in the short, medium and long term. 3. Provide assistance to APFA in consultation with stakeholders, identification of sources of assistance and coordination of the stakeholder response to WSD. Read moreRead less
Assessment Of The Sensitivity Of Australia’s Aquatic Animal Disease Surveillance System Using Scenario Tree Modelling
Funder
Fisheries Research and Development Corporation
Funding Amount
$224,000.00
Summary
The sensitivity of an overall passive surveillance system is difficult to determine due to variability in factors such as disease characteristics, passive surveillance stakeholders and the likelihood that disease events will be reported and investigated. The WOAH Aquatic Animal Health Code also stipulates the primary evidence for historical freedom is passive surveillant information generated by a country’s early detection system that needs to be sufficiently sensitive.
Scenario tree m ....The sensitivity of an overall passive surveillance system is difficult to determine due to variability in factors such as disease characteristics, passive surveillance stakeholders and the likelihood that disease events will be reported and investigated. The WOAH Aquatic Animal Health Code also stipulates the primary evidence for historical freedom is passive surveillant information generated by a country’s early detection system that needs to be sufficiently sensitive.
Scenario tree modelling (STM) can be used to overcome those challenges. STM uses quantitative statistical methods to estimate the sensitivity of various components of the surveillance system (e.g. presentation of disease signs, disease recognition and reporting). These estimates can then be used to identify critical points in the system to which interventions can be targeted to improve the system. STM can be applied to any aquatic disease/industry of interest and there are some successful examples for terrestrial diseases/industries, both in Australia and overseas.
Two aquatic animal disease agents of trade and biosecurity significance, WSSV and megalocytiviruses, will be evaluated as case studies. These diseases are subject to import biosecurity measures and have significant production impacts, as they severely affect farmed and wild aquatic animal species that are valued by many stakeholders (e.g. aquaculture, capture fisheries, recreational fisheries and conservation groups). A sound STM assessment of each case study will support our early detection system through a quantitative evaluation of the speed of the detection, and improve our emergency disease response strategy by determining areas in our passive surveillance that, once strengthened, will provide a greater return on future investment.
As mentioned above, increasing the sensitivity of Australia’s passive surveillance is a national priority. This project is identified in AQUAPLAN 2022-2017 as Activity 3.3. The outcomes of this project are also used for other AQUAPLAN activities, National surveillance strategy (Activity 3.1) and Sector-specific surveillance plans (Activity 3.2). The data produced from this project will provide recommendations for various interventions to improve the overall performance of the passive surveillance system for the participating industries.
More broadly, the Fisheries Research and Development Corporation R&D Plan 2020-2025 identified building capability and capacity for biosecurity as a priority. In alignment with the R&D plan, successful outcomes of this project will improve understanding of disease transmission pathways which will enhance biosecurity practices. It will improve allocation of biosecurity resources (by identifying the most effective and cost-efficient way of investing resources in surveillance to get the best return), minimise biosecurity threats (by enhancing passive surveillance to accelerate an early detection) and improve market access for associated industry producers (by providing quantitative information on their passive surveillance sensitivity as a market access negotiation tool).
Objectives: 1. Quantitatively evaluate the sensitivity of Australia’s passive surveillance system for white spot disease 2. Quantitatively evaluate the sensitivity of Australia’s passive surveillance system for megalocytiviruses Read moreRead less
Clarence River Green Prawn Market Diversification Assistance Measures
Funder
Fisheries Research and Development Corporation
Funding Amount
$165,000.00
Summary
The Clarence River Region is known for its high-quality prawn markets. The region was kept profitable during COVID restrictions due to a significant portion of the fisher directing its product to the highly profitable bait market. This diversification away from the consumer market has ensured stability for the region. Many fishing businesses pivoted their strategies to meet this new buyer to the region. The loss of the uncooked prawn market in the Clarence region will therefore destabilize t ....The Clarence River Region is known for its high-quality prawn markets. The region was kept profitable during COVID restrictions due to a significant portion of the fisher directing its product to the highly profitable bait market. This diversification away from the consumer market has ensured stability for the region. Many fishing businesses pivoted their strategies to meet this new buyer to the region. The loss of the uncooked prawn market in the Clarence region will therefore destabilize the industry. The restriction of uncooked prawn trade therefore must be addressed through market research, diversification and activation. However, there is immediate need for alternative markets so an intense focused market activation and access is the key. PFA has identified key market persons that can create links between industry and high-end chefs to: 1. Identify alternative market uses that fall within the quarantine requirements 2. Start immediate market trials and activation 3. Review online presence and build industry skills to improve online presence for sales • It is intended that this will lead into immediate supply agreements to these alternative markets that will in turn remove burden on the existing cooked prawn market
Objectives: 1. To identify and trial supplies of Clarence River prawns to alternative market 2. To activate alternative markets to reduce negative impact of trade restriction to the Clarence River region 3. To build skills within local fishers to build online presence Read moreRead less