Privacy preserving and data utility in outsourced systems. Making the best tradeoff between data privacy and utility is a vital challenge in privacy-preserving outsourcing environments. This project aims to develop a balanced distributed framework to achieve the best utility of outsourced data while protecting private information. The framework consists of general structure of distributed evolutionary algorithms and a predefined topology for high optimization efficiency and a dynamic groupin ....Privacy preserving and data utility in outsourced systems. Making the best tradeoff between data privacy and utility is a vital challenge in privacy-preserving outsourcing environments. This project aims to develop a balanced distributed framework to achieve the best utility of outsourced data while protecting private information. The framework consists of general structure of distributed evolutionary algorithms and a predefined topology for high optimization efficiency and a dynamic grouping recombination model. The project outcomes will be beneficial to applications in the nation as it incorporates new privacy constraints and utility requirements raised by emerging technologies to enable better protection of sensitive information and maximal data utility in outsourced systems. Read moreRead less
A data driven paradigm for service-oriented system engineering. This project aims to design and develop a data driven paradigm for service-oriented system engineering that allows system engineers and domain experts in different domains to build software systems easily in order to enable fast technology transfer within and across domain boundaries. This model integrates and automates a suite of efficient approaches for system structure determination, validation and recommendation based on keyword ....A data driven paradigm for service-oriented system engineering. This project aims to design and develop a data driven paradigm for service-oriented system engineering that allows system engineers and domain experts in different domains to build software systems easily in order to enable fast technology transfer within and across domain boundaries. This model integrates and automates a suite of efficient approaches for system structure determination, validation and recommendation based on keyword search, subgraph isomorphism and substructure query techniques. This project is expected to significantly accelerate the application of new technologies, for example, big data analytics and Internet of Things, in many of Australia's critical domains such as e-Health, smart cities, and cybersecurity.Read moreRead less
Developing an effective defence to cyber-reputation manipulation attacks. This project will develop new technologies for businesses to accurately identify fake internet reviews. Fake reviews, paid for and/or written with malicious intent, can cause irreparable damage to businesses resulting in revenue loss, consumer dissatisfaction or even closure of businesses. However they are difficult to identify, as they continuously evolve to avoid detection and the volume of Internet reviews makes analysi ....Developing an effective defence to cyber-reputation manipulation attacks. This project will develop new technologies for businesses to accurately identify fake internet reviews. Fake reviews, paid for and/or written with malicious intent, can cause irreparable damage to businesses resulting in revenue loss, consumer dissatisfaction or even closure of businesses. However they are difficult to identify, as they continuously evolve to avoid detection and the volume of Internet reviews makes analysis a monumental task. This project will provide advanced tools to detect fake website reviews and a cybersecurity system prototype ready to be used by industry, making Australia a leader in this field and resulting in a safer internet environment for all.Read moreRead less
New digital deep-time exploration tools for a low-emissions economy. Demand for critical minerals will soar as renewable energy generation increases, but exploration companies currently cannot take full advantage of available exploration data in an Earth evolution context. This project will generate new knowledge in big and complex geodata analysis using an innovative data mining approach. It will enable Lithodat, a small enterprise, to perform cloud-based plate tectonic reconstruction, visualis ....New digital deep-time exploration tools for a low-emissions economy. Demand for critical minerals will soar as renewable energy generation increases, but exploration companies currently cannot take full advantage of available exploration data in an Earth evolution context. This project will generate new knowledge in big and complex geodata analysis using an innovative data mining approach. It will enable Lithodat, a small enterprise, to perform cloud-based plate tectonic reconstruction, visualisation and spatio-temporal analysis of geodata for resource exploration. The outcomes include an enhanced capacity to generate ore prospectivity maps and an improved understanding of their tectonic, geochemical, and geophysical signatures, benefiting Lithodat and their clients in the search for new mineral deposits.Read moreRead less
Novel Nanotechnology Strategies For Drug Co-delivery And Combined Therapies In The Brain
Funder
National Health and Medical Research Council
Funding Amount
$1,512,250.00
Summary
Key challenges for treating brain diseases include effective delivery of drugs into the brain and targeted delivery to pathogenic areas. I have developed two world-first drug delivery systems that address these challenges. This project will expand their loading and brain delivery capability to deliver a broad range of novel multiple therapeutics to target sites in the brain. Human brain disease models will be used for systematic preclinical evaluation of novel delivery systems and therapeutics.
A Long-Lasting Oral Drug Delivery System Using Spiky Silica Nanoparticles
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
This project aims to develop a novel silica nanoparticle-based delivery system for long-lasting oral drug delivery. The particles will be engineered with a spiky morphology that will increase adhesion to the gastrointestinal tract enabling sustained drug release for days or even weeks. Longer lasting oral drug formulations would make it much easier for patients to adhere to the treatment schedules required in chronic diseases like HIV and increase the effectiveness of therapy.
AI-driven Effective Query Formulation for Better Systematic Reviews. This project aims to develop novel AI-based search engine methods to make the creation of systematic reviews cheaper, faster and unbiased. Systematic reviews are the cornerstone for evidence-based decisions in clinical practice and government policy making. Given the pace new research is published at, it is unsustainable to manually conduct systematic reviews in the traditional manner, taking on average 2 years and $350K and be ....AI-driven Effective Query Formulation for Better Systematic Reviews. This project aims to develop novel AI-based search engine methods to make the creation of systematic reviews cheaper, faster and unbiased. Systematic reviews are the cornerstone for evidence-based decisions in clinical practice and government policy making. Given the pace new research is published at, it is unsustainable to manually conduct systematic reviews in the traditional manner, taking on average 2 years and $350K and becoming already outdated when published. The outcomes of this project will lead to systematic reviews of higher quality, while reducing their financial and temporal costs, providing significant benefits to organisations performing reviews and their funders, and to people impacted by decisions made from the reviews.Read moreRead less
Contextual Behabiour Predictions in Dynamic Mobile E-commerce. The project aims to address behaviour prediction and develop novel techniques and tools for modelling, predicting human behaviours and making effective recommendations based on ubiquitous user behaviour data in mobile e-commerce. The techniques enable multi-source data fusion, context learning and model adaptation, and dynamic recommendation with interpretability ability. Expected outcomes include advances in data analytics theory an ....Contextual Behabiour Predictions in Dynamic Mobile E-commerce. The project aims to address behaviour prediction and develop novel techniques and tools for modelling, predicting human behaviours and making effective recommendations based on ubiquitous user behaviour data in mobile e-commerce. The techniques enable multi-source data fusion, context learning and model adaptation, and dynamic recommendation with interpretability ability. Expected outcomes include advances in data analytics theory and informed decision-making. This provides significant benefits of not only placing Australia in the forefront of exploiting multimodal user behaviour big data in dynamic e-commerce but also transforming Australian government and businesses to intelligent and contextual services adaptive to complex situations.Read moreRead less
Finding answers for complex questions. This project aims to develop a new search paradigm for on-line search engines that presents users with answers to complex questions, rather than forcing them to find answers themselves from lists of retrieved documents. The project will develop a taxonomy of complex answer search tasks, devise novel techniques to increase the effectiveness of complex answer retrieval through interaction and, create a new evaluation framework for precise measurement of syste ....Finding answers for complex questions. This project aims to develop a new search paradigm for on-line search engines that presents users with answers to complex questions, rather than forcing them to find answers themselves from lists of retrieved documents. The project will develop a taxonomy of complex answer search tasks, devise novel techniques to increase the effectiveness of complex answer retrieval through interaction and, create a new evaluation framework for precise measurement of system effectiveness. This project should provide significant advances that will benefit all users of search engines.Read moreRead less