Tropical Infectious Diseases - Pathogenisis And Vaccine Research
Funder
National Health and Medical Research Council
Funding Amount
$7,311,989.00
Summary
The diseases on which three themes of the work proposed centre, malaria, streptococcal diseases and scabies are infectious diseases largely affecting indigenous people in various parts of the world on a massive scale, for which there are no vaccines. The aim of the work is to develop vaccines or other biological prevention measures against each of these diseases and the problems that need to be solved are similar. The team includes senior experts on thebiology of infectious diseases with long hi ....The diseases on which three themes of the work proposed centre, malaria, streptococcal diseases and scabies are infectious diseases largely affecting indigenous people in various parts of the world on a massive scale, for which there are no vaccines. The aim of the work is to develop vaccines or other biological prevention measures against each of these diseases and the problems that need to be solved are similar. The team includes senior experts on thebiology of infectious diseases with long histories of collaboration as well as younger members with impressive credentials that are new to the collaboration. The fourth theme of the work proposed is concerned with inventive new ways of making such vaccines by novelchemical methods. It has already been the subject of published collaborative work onstreptococcal disease and is equally applicable to the other themes.Read moreRead less
This program, run by an established team with skills in public health, clinical epidemiology, biostatistics, health economics and behavioural science addresses the under-researched issues of whether, when and how to use medical tests. The elements of the program follow the sequence in which testing is often done: for screening (early detection), for diagnosis on which to base treatment decisions, and for monitoring the effects of treatment. A common approach throughout is the identification of t ....This program, run by an established team with skills in public health, clinical epidemiology, biostatistics, health economics and behavioural science addresses the under-researched issues of whether, when and how to use medical tests. The elements of the program follow the sequence in which testing is often done: for screening (early detection), for diagnosis on which to base treatment decisions, and for monitoring the effects of treatment. A common approach throughout is the identification of the benefits and harms of testing and assessing their trade-off; how benefits weigh up against harms. This research is relevant to all partners in healthcare, (consumers, clinicians and policy-makers), who currently are being tested or using tests without being fully informed about the accuracy and effects of these tests.Read moreRead less
Advances In Clinical Trials Research And Evidence Based Decision Making
Funder
National Health and Medical Research Council
Funding Amount
$6,712,859.00
Summary
The NHMRC Clinical Trials Centre at the University of Sydney aims to use clinical trials and methodological research in trials to improve health in Australia and internationally It is a member of many international collaborative trials groups, especially in heart disease and cancer. A particular area of interest is patient preferences and decision making, particularly in cancer. The Clinical Trial Centre is active in using data from its own and other clinical trials in combined analyses to arriv ....The NHMRC Clinical Trials Centre at the University of Sydney aims to use clinical trials and methodological research in trials to improve health in Australia and internationally It is a member of many international collaborative trials groups, especially in heart disease and cancer. A particular area of interest is patient preferences and decision making, particularly in cancer. The Clinical Trial Centre is active in using data from its own and other clinical trials in combined analyses to arrive at better evidence.Read moreRead less
Health Outcomes Monitoring And Evaluation: Learning About Activity, Nutrition, Diet And Social Factors
Funder
National Health and Medical Research Council
Funding Amount
$7,486,989.00
Summary
Diabetes, Heart and Kidney disease occur in epidemic proportions among Indigenous Australians. Of particular concerns is the early age of onset of conditions that are to disease of older adulthood in the broader Australian community. While these chronic diseases are known to cause premature death and suffering in Aboriginal and Torres Strait Islander communities, there are gaps in our knowledge. For example, we know very little about how these conditionsdevelop over time in different populations ....Diabetes, Heart and Kidney disease occur in epidemic proportions among Indigenous Australians. Of particular concerns is the early age of onset of conditions that are to disease of older adulthood in the broader Australian community. While these chronic diseases are known to cause premature death and suffering in Aboriginal and Torres Strait Islander communities, there are gaps in our knowledge. For example, we know very little about how these conditionsdevelop over time in different populations. Probably the greatest knowledge gap is the area of effective intervention - both to prevent to prevent diabetes, kidney and heart disease in young people, and to treat existing cases effectivly. The main goal of this program is to bring together a multi skilled team of researchers to better understand the development of these chronic disease across the lifespan ( including differences between different populations), and to guuide the development of diet, lifestyle, and clinical interventions. Such interventions need to be simple, effective, acceptable to Indigenous people and able to be sustained over the long term. All interventions will be rigorously evaluated. The results will inform policies in ares such as quality and affordability of the food supply in remote communnities; infrastructure to promote physical activity; and provision of high quality primary health care focussing on early intervention and care of people at risk of chronic disease.Read moreRead less