A Randomised, Double Blinded Intervention Study To Assess Health Effects Of Drinking Water From Rainwater Tanks
Funder
National Health and Medical Research Council
Funding Amount
$860,510.00
Summary
We are planning to perform a study in Adelaide to assess if drinking untreated rainwater causes a health risk. Eight years into a drought Australia's water sources are becoming increasingly depleted, so we need to reduce water consumption and consider using alternative sources of water. Increased use of rainwater is one of a number of solutions available. However, current recommendations state that rainwater can be safely used for purposes other than drinking, but because of potential contaminat ....We are planning to perform a study in Adelaide to assess if drinking untreated rainwater causes a health risk. Eight years into a drought Australia's water sources are becoming increasingly depleted, so we need to reduce water consumption and consider using alternative sources of water. Increased use of rainwater is one of a number of solutions available. However, current recommendations state that rainwater can be safely used for purposes other than drinking, but because of potential contamination and limited evidence regarding safety, drinking untreated rainwater is not approved by state health departments. The main outcome of this study will be to determine whether drinking untreated water from rainwater tanks poses a significant health risk. Additionally, we will determine if specific tank or maintenance characteristics can be identified that increase illness risk. The study design consists of following the health of 300 families who drink unboiled rainwater. Families will have a special tap installed that draws water through a water treatment unit (WTU). Half the families will have a working WTU and half will have a sham unit identical in appearance. The functional units sterilise water to remove any microorganisms present, while the sham filters have no effect. All participating families will keep a health diary for one year to record how often they suffer gastroenteritis. Neither the families nor the research workers will know which type of filter has been fitted. Water samples will be collected from selected households. At the end of a year the number of illnesses in the two groups will be compared. If those drinking rainwater from a sham filter suffer more often, then rainwater would be implicated as a source of gastroenteritis. This study will provide health authorities with a better understanding of the relationship between rainwater consumption and human health, and will provide data regarding safe uses of this alternative water source.Read moreRead less
Quantifying The Microbial Health Risks Of Expanded Alternative Water Use
Funder
National Health and Medical Research Council
Funding Amount
$305,496.00
Summary
Addressing current and future water shortages requires substitution of high quality drinking water with alternative water sources for an expanded range of purposes. However, potential adverse health effects must be avoided. This project measures health risks associated with a variety of alternative water sources and water use combinations. Project outputs will help determine appropriate requirements for water treatment and help refine guidelines to ensure that water use is safe.
Novel Use Of Fungal Entomopathogens For Sustainable Control Of Mosquito-borne Viruses
Funder
National Health and Medical Research Council
Funding Amount
$605,993.00
Summary
Mosquito-born viruses such as Dengue, Ross River and Barmah Forest are increasing in regional significance. At a broader scale, an estimated 2.5 billion people live in areas at risk of epidemic Dengue transmission. Chemical insecticides are the mainstay of current mosquito control throughout many parts of the world. However, problems of insecticide resistance, environmental contamination and risks to human health, mean that chemical pesticides have not provided a universal solution, either as ou ....Mosquito-born viruses such as Dengue, Ross River and Barmah Forest are increasing in regional significance. At a broader scale, an estimated 2.5 billion people live in areas at risk of epidemic Dengue transmission. Chemical insecticides are the mainstay of current mosquito control throughout many parts of the world. However, problems of insecticide resistance, environmental contamination and risks to human health, mean that chemical pesticides have not provided a universal solution, either as outdoor sprays, residual house sprays or as insecticide treated nets. This creates a pressing need for practical alternatives. Building on approaches and technologies developed for control of locusts in Australia and Africa, we have recently discovered that the ability of mosquitoes to transmit malaria can be substantially reduced with insect fungal pathogens used as biological pesticides. We found that exposure to biopesticide-treated surfaces reduced the number of mosquitoes able to transmit malaria 80-fold. Other supporting data from semi-field trials confirm the feasibility of infecting mosquitoes under real field conditions. Together, these results represent a significant advance in the development of a cheap and sustainable biological alternative to chemical insecticides for disease control. We now wish to extend this research to explore the potential for use of fungal pathogens in control of mosquito-borne viruses. Preliminary studies already confirm that we can infect the key mosquito species responsible for transmitting Dengue. The aim of the current project is to conduct a more comprehensive evaluation of a wider range of fungal isolates to identify strains with the greatest potential to stop transmission of mosquito-borne viruses. The longer term goal is to translate this research into a practical product. Such a product would offer a cheap, environmentally friendly disease control measure, with reduced potential for resistance evolution.Read moreRead less
Improving Access To Safe Water Using Riverbank Filtration Technology
Funder
National Health and Medical Research Council
Funding Amount
$1,056,616.00
Summary
Diarrhoea is a leading cause of death and disease globally, most often due to unsafe water, inadequate sanitation and poor hygiene. River water is a common water source in India, but water quality is often compromised by contamination. Riverbank Filtration technology (RBF) uses natural treatment processes to improve water quality. This project will investigate the effect of improving water quality via installation of RBF systems on diarrhoea incidence in six rural Indian communities.
Investigating The Incremental Health Benefits Of Improving Water Quantity Versus Improving Water Quality Using Riverbank Filtration Technology (RBF) In Six Rural Communities In India
Funder
National Health and Medical Research Council
Funding Amount
$122,714.00
Summary
Diarrhoea is a leading cause of death and disease globally, largely attributable to unsafe water, inadequate sanitation and poor hygiene. River water is a common water source in India, but water quality is often compromised by contamination. Riverbank Filtration technology (RBF) is an inexpensive means to improve water quality. This project will investigate the health benefits of improving water quantity versus improving water quality using RBF technology in six rural Indian communities.
Minimising Infection Risks Associated With Water Exposure And With International Travel: Addressing Data Gaps To Improve Policy And Practice
Funder
National Health and Medical Research Council
Funding Amount
$401,361.00
Summary
This project will provide better understanding of health risks associated with two areas of infectious diseases: i) exposure to water, including water recycling and ii) imported infections associated with international travel. Both these issues are highly topical, and new information about exposure risks is important to help guide appropriate preventive advice.
Establishing Australian Health Based Targets For Microbial Water Quality
Funder
National Health and Medical Research Council
Funding Amount
$174,799.00
Summary
It is of great public health importance to ensure that our drinking water supplies are safe. This is true both for conventional drinking water supplies and for supplies derived from alternative water sources, including water derived from recycled sewage. National guidelines exist for management of drinking water and recycled water supplies, but currently there are no targets for determining whether water has an acceptably low level of infectious agents. This project involves a number of steps to ....It is of great public health importance to ensure that our drinking water supplies are safe. This is true both for conventional drinking water supplies and for supplies derived from alternative water sources, including water derived from recycled sewage. National guidelines exist for management of drinking water and recycled water supplies, but currently there are no targets for determining whether water has an acceptably low level of infectious agents. This project involves a number of steps to develop national consensus on health targets for microbial water qualityRead moreRead less
An Investigation Into The Importance Of Potable Water As A Source Of Melioidosis In Northern Australia
Funder
National Health and Medical Research Council
Funding Amount
$362,036.00
Summary
Melioidosis is a potentially fatal infection that occurs throughout the Top End. Infection usually sets in after exposure to contaminated soil or surface water. A recent outbreak of melioidosis in which three of seven cases died was traced to the community's drinking water supply. Subsequent improvements to the community's drinking water treatment appear to have brought the outbreak under control. However, the ability of the bacteria responsible for this infection to survive within the body for ....Melioidosis is a potentially fatal infection that occurs throughout the Top End. Infection usually sets in after exposure to contaminated soil or surface water. A recent outbreak of melioidosis in which three of seven cases died was traced to the community's drinking water supply. Subsequent improvements to the community's drinking water treatment appear to have brought the outbreak under control. However, the ability of the bacteria responsible for this infection to survive within the body for many years before causing late onset infection means that further cases may be recorded in the affected community for years to come. This project aims to assess whether the drinking water supply to other rural communities presents a risk of melioidosis throughout the Top End. Drinking water supplies will be tested for the presence of the bacteria that cause melioidosis. Genetic fingerprinting will be used to compare each strain isolated from water specimens with strains obtained from infections previously diagnosed in hospitals throughout the Top End. This will involve the combined efforts of researchers in Western Australia, the Northern Territory and Queensland. Comparison of these results with standard measures of drinking water quality will enable the research team to work out whether any routinely performed tests can be used as a guide to melioidosis risk. The team will also examine whether any geographical features such as deep water supply or the type of vegetation present can be used to assess melioidosis risk. A clearer picture of melioidosis risk will make it easier to target the delivery of preventive methods such as chlorination or alternatives to specific water supplies. Preliminary studies in Western Australia suggest that primary prevention of melioidosis may be possible. We need to see how widely those findings apply. It is hoped that this work will lead to a significant reduction in the risk of contracting this disease throughout the endemic region.Read moreRead less
Development Of Novel Antibacterial Compounds From Subtilosin A
Funder
National Health and Medical Research Council
Funding Amount
$490,724.00
Summary
We aim to overcome a problem that is not being addressed by pharmaceutical companies- i.e., there is an urgent need to develop new classes of antibacterial drugs because of the increasing prevalence of drug resistant bacteria. We will combine genetics, structural biology and chemistry to develop a new class of anti-bacterial drug based on a naturally occurring microbial molecule that is novel in structure and very stable- attributes that make it very different to existing therapeutic approaches.