Discovery Early Career Researcher Award - Grant ID: DE200101832
Funder
Australian Research Council
Funding Amount
$425,941.00
Summary
Mechanisms of immune protection for infectious laryngotracheitis virus. This project aims to investigate the mechanisms of immune protection against infectious laryngotracheitis virus. This will be achieved by investigating the role of local and systemic immunity and the immune cells associated with long-term protection against disease. The mechanisms of protection against this virus remain unknown which impairs the development of efficacious vaccines. Expected outcomes of this project are a mor ....Mechanisms of immune protection for infectious laryngotracheitis virus. This project aims to investigate the mechanisms of immune protection against infectious laryngotracheitis virus. This will be achieved by investigating the role of local and systemic immunity and the immune cells associated with long-term protection against disease. The mechanisms of protection against this virus remain unknown which impairs the development of efficacious vaccines. Expected outcomes of this project are a more rational approach to vaccination resulting in the generation of more effective and safer vaccination strategies that should benefit our important poultry industry. Additionally, the new methodologies and knowledge on mucosal immune markers could be utilised for the study of other pathogens.Read moreRead less
New antiparasitics to protect Australian livestock. There is an urgent need for new antiparasitics to treat multi-drug resistant livestock infections. This project aims to explore the bacteria and fungi present in the microbiomes of heavily infected sheep faeces and pastures, challenging them with environmental cues, including those from associated parasites, to stimulate production of defensive chemicals hidden deep within their genomes. Enabled by an integrated pipeline of high throughput anal ....New antiparasitics to protect Australian livestock. There is an urgent need for new antiparasitics to treat multi-drug resistant livestock infections. This project aims to explore the bacteria and fungi present in the microbiomes of heavily infected sheep faeces and pastures, challenging them with environmental cues, including those from associated parasites, to stimulate production of defensive chemicals hidden deep within their genomes. Enabled by an integrated pipeline of high throughput analytical cultivation, molecular networking, and chemical and biological analyses, expected outcomes include an enhanced ability to explore and exploit valuable chemistry hidden within microbial genomes, leading to the discovery of new classes of natural antiparasitic to safeguard livestock.
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Industrial Transformation Training Centres - Grant ID: IC220100050
Funder
Australian Research Council
Funding Amount
$4,508,426.00
Summary
ARC Training Centre for Environmental and Agricultural Solutions to Antimicrobial Resistance (ARC CEA-StAR). The ARC Training Centre for Environmental and Agricultural Solutions to Antimicrobial Resistance aims to develop industry-led solutions and train a new generation of researchers to combat the impact of antimicrobial resistance (AMR) on agribusiness and the environment.
AMR is a global health and economic threat that epitomises the need for a ‘One Health’ collaborative approach encompassi ....ARC Training Centre for Environmental and Agricultural Solutions to Antimicrobial Resistance (ARC CEA-StAR). The ARC Training Centre for Environmental and Agricultural Solutions to Antimicrobial Resistance aims to develop industry-led solutions and train a new generation of researchers to combat the impact of antimicrobial resistance (AMR) on agribusiness and the environment.
AMR is a global health and economic threat that epitomises the need for a ‘One Health’ collaborative approach encompassing the interconnection between people, animals, plants, and their shared environment.
Expected outcomes of this collaborative program include a cohort of researchers trained in industry-relevant techniques, furnishing solutions to partner-defined AMR challenges, and providing significant benefits by positioning Australia as a global leader in reducing AMR.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100295
Funder
Australian Research Council
Funding Amount
$455,563.00
Summary
Unlocking the helminth ‘early infection gap’ using 3D cell culture models. This project aims to revolutionise the study of critical early host-parasite interactions using innovative 3D cell culture models, reducing our dependence on animal infections. Liver fluke is the most economically important zoonotic parasite of Australian livestock and is a significant contributor to global food insecurity. Due to the reliance of parasites on mammalian hosts to survive, very little is known about the earl ....Unlocking the helminth ‘early infection gap’ using 3D cell culture models. This project aims to revolutionise the study of critical early host-parasite interactions using innovative 3D cell culture models, reducing our dependence on animal infections. Liver fluke is the most economically important zoonotic parasite of Australian livestock and is a significant contributor to global food insecurity. Due to the reliance of parasites on mammalian hosts to survive, very little is known about the early infection process. Expected outcomes include new knowledge on key migratory stimuli and liver fluke biology. Benefits include the identification of drug targets and vaccine candidates for use in livestock via the development of animal-free in vitro screening platforms that will serve as a prototype for other parasites.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101155
Funder
Australian Research Council
Funding Amount
$425,952.00
Summary
From stormwater to potable water via Water Sensitive Urban Design? The project aims to develop a framework that contains viable procedures to quantify, control and monitor the health risks associated with stormwater harvesting using Water Sensitive Urban Design (WSUD) systems (i.e., natural-based solutions). It expects to address the concerns about the safety of stormwater harvesting via WSUD for all end-uses. It will generate new knowledge regarding the real time control and monitoring of WSUD, ....From stormwater to potable water via Water Sensitive Urban Design? The project aims to develop a framework that contains viable procedures to quantify, control and monitor the health risks associated with stormwater harvesting using Water Sensitive Urban Design (WSUD) systems (i.e., natural-based solutions). It expects to address the concerns about the safety of stormwater harvesting via WSUD for all end-uses. It will generate new knowledge regarding the real time control and monitoring of WSUD, thus truly advancing the WUSD technology as emerging urban green infrastructure for reliable stormwater harvesting. Expected outcomes include next generation of WSUDs implemented with real time control techniques, as well as a suite of easy-to-measure surrogate parameters for real time water quality monitoring.Read moreRead less
Passive biofiltration processes for nitrogen removal from polluted waters. Traditional urban wastewater treatment is energy and resource demanding. By combining principles of Water Sensitive Urban Design (WSUD) with advanced pollutant removal processes, we will create necessary knowledge to underpin development of novel sustainable urban water treatment systems. This project aims to understand and utilise Simultaneous Nitrification, Anammox and Denitrification (SNAD) processes within passive pla ....Passive biofiltration processes for nitrogen removal from polluted waters. Traditional urban wastewater treatment is energy and resource demanding. By combining principles of Water Sensitive Urban Design (WSUD) with advanced pollutant removal processes, we will create necessary knowledge to underpin development of novel sustainable urban water treatment systems. This project aims to understand and utilise Simultaneous Nitrification, Anammox and Denitrification (SNAD) processes within passive plant-soil-based biofilters for cost-effective removal of nitrogen from a range of polluted urban water sources. The project will open a potential for a new technological advancements in urban water management, while simultaneously providing benefits to the environment and community through greening and waterway protection.Read moreRead less
Mitigating the risk of cyanobacterial blooms in wastewater ponds. Cyanobacterial blooms in wastewater treatment plants impact on effluent quality and the utility of recycled water, posing a significant risk to the economy, the environment and public health. To understand the causes of cyanobacterial blooms in pond-based wastewater treatment plants and the risk they pose, this project will use the latest molecular techniques to examine how the microbial communities within these systems interact w ....Mitigating the risk of cyanobacterial blooms in wastewater ponds. Cyanobacterial blooms in wastewater treatment plants impact on effluent quality and the utility of recycled water, posing a significant risk to the economy, the environment and public health. To understand the causes of cyanobacterial blooms in pond-based wastewater treatment plants and the risk they pose, this project will use the latest molecular techniques to examine how the microbial communities within these systems interact with each other and their surrounding environment to form blooms and produce toxins and other harmful metabolites. Such knowledge will inform risk assessment and provide strategies for the mitigation of future bloom events, improving the security of our increasingly valuable recycled water resources.Read moreRead less
Water availability and demand: better forecasts, better management. This project aims to improve Australia’s capability in the provision and use of water forecasts for managing water resources. The current water forecasts are not fully utilised by water agencies as they are not sufficiently comprehensive and advanced. This project expects to achieve a step change in the uptake and utility of hydro-climate forecasts through an extensive partnership of leading researchers and operational agencies ....Water availability and demand: better forecasts, better management. This project aims to improve Australia’s capability in the provision and use of water forecasts for managing water resources. The current water forecasts are not fully utilised by water agencies as they are not sufficiently comprehensive and advanced. This project expects to achieve a step change in the uptake and utility of hydro-climate forecasts through an extensive partnership of leading researchers and operational agencies of hydro-climate forecasting, with federal, state and regional water agencies.Read moreRead less
Validation and monitoring of advanced oxidation for potable water reuse. This project aims to address an important limitation in the ability to monitor performance of advanced oxidation processes used to treat recycled water for drinking. The project will be conducted using a novel pilot system, designed to facilitate flexible operation and detailed monitoring. Through carefully designed experiments, observed operational parameters will be related to treatment performance for a range of contamin ....Validation and monitoring of advanced oxidation for potable water reuse. This project aims to address an important limitation in the ability to monitor performance of advanced oxidation processes used to treat recycled water for drinking. The project will be conducted using a novel pilot system, designed to facilitate flexible operation and detailed monitoring. Through carefully designed experiments, observed operational parameters will be related to treatment performance for a range of contaminants. An expected outcome is the development of a framework to provide validation of process performance relationships and ongoing performance monitoring for use by water utilities and regulatory agencies that oversee their operations. This highly practical framework for validation and performance monitoring of an advanced water treatment process should result in improved viability of water recycling projects, increased urban water supply security and enhanced protection of public health.Read moreRead less
Mid-Career Industry Fellowships - Grant ID: IM230100222
Funder
Australian Research Council
Funding Amount
$865,628.00
Summary
Large scale urban stormwater reuse: safe, clear and odourless water supply. This project aims to improve the resilience of Australian water supplies by building capacity in urban stormwater reuse. The project expects to address an industry-identified need to determine the suitability of urban lakes and wetlands for stormwater harvesting and develop chemical-sensory monitoring techniques to assess the quality of harvested water. Expected outcomes include the establishment of satellite-based remot ....Large scale urban stormwater reuse: safe, clear and odourless water supply. This project aims to improve the resilience of Australian water supplies by building capacity in urban stormwater reuse. The project expects to address an industry-identified need to determine the suitability of urban lakes and wetlands for stormwater harvesting and develop chemical-sensory monitoring techniques to assess the quality of harvested water. Expected outcomes include the establishment of satellite-based remote sensing as a key technology for stormwater applications and the widespread use of improved techniques for monitoring odorants by the water industry. This should provide significant benefits by informing adaptive planning and infrastructure readiness at water utilities and guiding Australian policy on stormwater reuse.Read moreRead less