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Minimising Infection Risks Associated With Water Exposure And With International Travel: Addressing Data Gaps To Improve Policy And Practice
Funder
National Health and Medical Research Council
Funding Amount
$401,361.00
Summary
This project will provide better understanding of health risks associated with two areas of infectious diseases: i) exposure to water, including water recycling and ii) imported infections associated with international travel. Both these issues are highly topical, and new information about exposure risks is important to help guide appropriate preventive advice.
An Investigation Into The Importance Of Potable Water As A Source Of Melioidosis In Northern Australia
Funder
National Health and Medical Research Council
Funding Amount
$362,036.00
Summary
Melioidosis is a potentially fatal infection that occurs throughout the Top End. Infection usually sets in after exposure to contaminated soil or surface water. A recent outbreak of melioidosis in which three of seven cases died was traced to the community's drinking water supply. Subsequent improvements to the community's drinking water treatment appear to have brought the outbreak under control. However, the ability of the bacteria responsible for this infection to survive within the body for ....Melioidosis is a potentially fatal infection that occurs throughout the Top End. Infection usually sets in after exposure to contaminated soil or surface water. A recent outbreak of melioidosis in which three of seven cases died was traced to the community's drinking water supply. Subsequent improvements to the community's drinking water treatment appear to have brought the outbreak under control. However, the ability of the bacteria responsible for this infection to survive within the body for many years before causing late onset infection means that further cases may be recorded in the affected community for years to come. This project aims to assess whether the drinking water supply to other rural communities presents a risk of melioidosis throughout the Top End. Drinking water supplies will be tested for the presence of the bacteria that cause melioidosis. Genetic fingerprinting will be used to compare each strain isolated from water specimens with strains obtained from infections previously diagnosed in hospitals throughout the Top End. This will involve the combined efforts of researchers in Western Australia, the Northern Territory and Queensland. Comparison of these results with standard measures of drinking water quality will enable the research team to work out whether any routinely performed tests can be used as a guide to melioidosis risk. The team will also examine whether any geographical features such as deep water supply or the type of vegetation present can be used to assess melioidosis risk. A clearer picture of melioidosis risk will make it easier to target the delivery of preventive methods such as chlorination or alternatives to specific water supplies. Preliminary studies in Western Australia suggest that primary prevention of melioidosis may be possible. We need to see how widely those findings apply. It is hoped that this work will lead to a significant reduction in the risk of contracting this disease throughout the endemic region.Read moreRead less
Dengue, Zika and Chikungunya are viral diseases transmitted to humans by mosquitoes. Our research uses a naturally-occurring bacteria, Wolbachia, to stop mosquitoes transmitting these viruses to humans. Our proposal addresses critical knowledge gaps in the biology of mosquitoes and Wolbachia to enable large-scale field-deployment optimisation in affected countries. The outcome of our research will immediately translate to disease control efforts in northern Australia, Asia and Latin America.
Improving Access To Safe Water Using Riverbank Filtration Technology
Funder
National Health and Medical Research Council
Funding Amount
$1,056,616.00
Summary
Diarrhoea is a leading cause of death and disease globally, most often due to unsafe water, inadequate sanitation and poor hygiene. River water is a common water source in India, but water quality is often compromised by contamination. Riverbank Filtration technology (RBF) uses natural treatment processes to improve water quality. This project will investigate the effect of improving water quality via installation of RBF systems on diarrhoea incidence in six rural Indian communities.
Investigating The Incremental Health Benefits Of Improving Water Quantity Versus Improving Water Quality Using Riverbank Filtration Technology (RBF) In Six Rural Communities In India
Funder
National Health and Medical Research Council
Funding Amount
$122,714.00
Summary
Diarrhoea is a leading cause of death and disease globally, largely attributable to unsafe water, inadequate sanitation and poor hygiene. River water is a common water source in India, but water quality is often compromised by contamination. Riverbank Filtration technology (RBF) is an inexpensive means to improve water quality. This project will investigate the health benefits of improving water quantity versus improving water quality using RBF technology in six rural Indian communities.
A Randomised, Double Blinded Intervention Study To Assess Health Effects Of Drinking Water From Rainwater Tanks
Funder
National Health and Medical Research Council
Funding Amount
$860,510.00
Summary
We are planning to perform a study in Adelaide to assess if drinking untreated rainwater causes a health risk. Eight years into a drought Australia's water sources are becoming increasingly depleted, so we need to reduce water consumption and consider using alternative sources of water. Increased use of rainwater is one of a number of solutions available. However, current recommendations state that rainwater can be safely used for purposes other than drinking, but because of potential contaminat ....We are planning to perform a study in Adelaide to assess if drinking untreated rainwater causes a health risk. Eight years into a drought Australia's water sources are becoming increasingly depleted, so we need to reduce water consumption and consider using alternative sources of water. Increased use of rainwater is one of a number of solutions available. However, current recommendations state that rainwater can be safely used for purposes other than drinking, but because of potential contamination and limited evidence regarding safety, drinking untreated rainwater is not approved by state health departments. The main outcome of this study will be to determine whether drinking untreated water from rainwater tanks poses a significant health risk. Additionally, we will determine if specific tank or maintenance characteristics can be identified that increase illness risk. The study design consists of following the health of 300 families who drink unboiled rainwater. Families will have a special tap installed that draws water through a water treatment unit (WTU). Half the families will have a working WTU and half will have a sham unit identical in appearance. The functional units sterilise water to remove any microorganisms present, while the sham filters have no effect. All participating families will keep a health diary for one year to record how often they suffer gastroenteritis. Neither the families nor the research workers will know which type of filter has been fitted. Water samples will be collected from selected households. At the end of a year the number of illnesses in the two groups will be compared. If those drinking rainwater from a sham filter suffer more often, then rainwater would be implicated as a source of gastroenteritis. This study will provide health authorities with a better understanding of the relationship between rainwater consumption and human health, and will provide data regarding safe uses of this alternative water source.Read moreRead less
Quantifying The Microbial Health Risks Of Expanded Alternative Water Use
Funder
National Health and Medical Research Council
Funding Amount
$305,496.00
Summary
Addressing current and future water shortages requires substitution of high quality drinking water with alternative water sources for an expanded range of purposes. However, potential adverse health effects must be avoided. This project measures health risks associated with a variety of alternative water sources and water use combinations. Project outputs will help determine appropriate requirements for water treatment and help refine guidelines to ensure that water use is safe.
A Functional And Structural Approach To Understanding Leptospiral Host-pathogen Interactions
Funder
National Health and Medical Research Council
Funding Amount
$504,097.00
Summary
Leptospirosis is a zoonosis of worldwide distribution caused by infection with pathogenic Leptospira. Infection occurs due to contact with water contaminated by urine of domestic animals. It occurs infrequently in Australia, but recent local surveillance data indicate hospitalisation rate of 56% with an average duration of 5.3 days. Through the combined approach of structural biology and functional microbiology we hope to understand how leptospira interacts with the human host.
Buruli ulcer (BU) is a destructive skin and soft tissue infection that can cause permanent deformity. Australian native possums carry in their guts the bacteria that causes BU and mosquitoes spread BU to people from areas contaminated by possum faeces. A targeted intervention based on screening possum faeces followed by control of mosquitoes in areas where possums and mosquitoes are shown to carry the bacteria will be trialed here, giving public health officials a means to stop this disease.